共查询到20条相似文献,搜索用时 0 毫秒
1.
In a meta-analysis of randomized trials of the effects of dietary sodium interventions on blood pressure, we found substantial heterogeneity among the studies. We were interested in evaluating whether measurement error, known to be a problem for dietary sodium measures, publication bias, or confounding factors could be responsible for the heterogeneity. A measurement error correction was developed that corrects both the slope and the intercept and takes into account the sample size of each study and the number of measurements taken on an individual. The measurement error correction had a minimal effect on the estimates, although it performed well in simulated data. A smoothed scatter plot was used to assess publication bias. Metaregressions provide a convenient way to jointly assess the effects of several factors, but care must be taken to fit an appropriate model. 相似文献
2.
Jackson D 《Biometrics》2007,63(1):187-193
Perhaps the greatest threat to the validity of a meta-analysis is the possibility of publication bias, where studies with interesting or statistically significant results are more likely to be published. This obviously impacts on inference concerning the treatment effect but also has implications for estimates of between-study variance. Two popular and established estimation methods are considered and formulae for assessing the implications of the bias are provided in terms of a general process for selecting studies. Meta-analysts, concerned that publication bias may be present, can use these as part of a sensitivity analysis to assess the robustness of their estimates of between-study variance using any selection process that is likely to be used in practice. The procedure is illustrated using a meta-analysis of clinical trials concerning the effectiveness of endoscopic sclerotherapy for preventing death in patients with cirrhosis and oesophagogastric varices. 相似文献
3.
Publication bias of the results of medical studies can invalidate evidence-based medicine. The existing methodology for modeling this essentially relies upon the symmetry of the funnel plot. We present a new method of modeling publication bias that uses this information plus the impact factors of the publishing journals. A simple model of the publication process enables the estimation of bias-corrected intervention effects. The procedure is illustrated using a meta-analysis of the effectiveness of single-dose oral aspirin for acute pain, and results are also obtained for five other meta-analyses. The method enables the fitting of a wide range of models and is considered more flexible than other ways of compensating for publication bias. The model also provides the basis of a statistical test for the existence of publication bias. Use of the new methodology to supplement existing methods is recommended, in the context of a sensitivity analysis. 相似文献
4.
The conservation literature provides an important resource for conservation practice and reflects key areas of current research interest, but not necessarily those of highest priority, in the field of conservation science. In one of the most comprehensive studies of its kind, this paper evaluates 4388 articles from three leading conservation journals with different impact factors (Biological Conservation, Conservation Letters, and Oryx) for the period 2010–2019. The analysis shows that previously identified trends still hold true in many instances, including a continuing taxonomic bias towards vertebrates and particularly in favour of mammals. Geographical biases also persist, favouring Europe and North America with respect to where research is undertaken, who writes about it, and how it is funded, although publication of research conducted in Africa is increasing. It is difficult to evaluate changes in author gender outside the decade studied as this topic has not been widely considered in previous studies, but parity in authorship has not yet been achieved in any of the journals examined. To overcome the biases identified, researchers, editors, and funding organisations collectively still need to do more to redirect conservation efforts where they are most urgently needed and encourage more women and more researchers from lower income countries to participate in research by helping to remove the barriers that currently limit them. 相似文献
5.
We study recently developed nonparametric methods for estimating the number of missing studies that might exist in a meta-analysis and the effect that these studies might have had on its outcome. These are simple rank-based data augmentation techniques, which formalize the use of funnel plots. We show that they provide effective and relatively powerful tests for evaluating the existence of such publication bias. After adjusting for missing studies, we find that the point estimate of the overall effect size is approximately correct and coverage of the effect size confidence intervals is substantially improved, in many cases recovering the nominal confidence levels entirely. We illustrate the trim and fill method on existing meta-analyses of studies in clinical trials and psychometrics. 相似文献
6.
We study publication bias in meta-analysis by supposing there is a population (y, sigma) of studies which give treatment effect estimates y approximately N(theta, sigma(2)). A selection function describes the probability that each study is selected for review. The overall estimate of theta depends on the studies selected, and hence on the (unknown) selection function. Our previous paper, Copas and Jackson (2004, Biometrics 60, 146-153), studied the maximum bias over all possible selection functions which satisfy the weak condition that large studies (small sigma) are as likely, or more likely, to be selected than small studies (large sigma). This led to a worst-case sensitivity analysis, controlling for the overall fraction of studies selected. However, no account was taken of the effect of selection on the uncertainty in estimation. This article extends the previous work by finding corresponding confidence intervals and P-values, and hence a new sensitivity analysis for publication bias. Two examples are discussed. 相似文献
7.
Evidence synthesis, both qualitatively and quantitatively through meta-analysis, is central to the development of evidence-based medicine. Unfortunately, meta-analysis is often complicated by the suspicion that the available studies represent a biased subset of the evidence, possibly due to publication bias or other systematically different effects in small studies. A number of statistical methods have been proposed to address this, among which the trim-and-fill method and the Copas selection model are two of the most widely discussed. However, both methods have drawbacks: the trim-and-fill method is based on strong assumptions about the symmetry of the funnel plot; the Copas selection model is less accessible to systematic reviewers, and sometimes encounters estimation problems. In this article, we adopt a logistic selection model, and show how treatment effects can be rapidly estimated via multiple imputation. Specifically, we impute studies under a missing at random assumption, and then reweight to obtain estimates under nonrandom selection. Our proposal is computationally straightforward. It allows users to increase selection while monitoring the extent of remaining funnel plot asymmetry, and also visualize the results using the funnel plot. We illustrate our approach using a small meta-analysis of benign prostatic hyperplasia. 相似文献
8.
Meta-analysis,funnel plots and sensitivity analysis 总被引:3,自引:0,他引:3
Publication bias is a major problem, perhaps the major problem, in meta-analysis (or systematic reviews). Small studies are more likely to be published if their results are 'significant' than if their results are negative or inconclusive, and so the studies available for review are biased in favour of those with positive outcomes. Correcting for this bias is not possible without making untestable assumptions. In this paper, a sensitivity analysis is suggested which is based on fitting a model to the funnel plot. Some examples are discussed. 相似文献
9.
10.
Publication bias and related types of small-study effects threaten the validity of systematic reviews. The existence of small-study effects has been demonstrated in empirical studies. Small-study effects are graphically diagnosed by inspection of the funnel plot. Though observed funnel plot asymmetry cannot be easily linked to a specific reason, tests based on funnel plot asymmetry have been proposed. Beyond a vast range of funnel plot tests, there exist several methods for adjusting treatment effect estimates for these biases. In this article, we consider the trim-and-fill method, the Copas selection model, and more recent regression-based approaches. The methods are exemplified using a meta-analysis from the literature and compared in a simulation study, based on binary response data. They are also applied to a large set of meta-analyses. Some fundamental differences between the approaches are discussed. An assumption common to the trim-and-fill method and the Copas selection model is that the small-study effect is caused by selection. The trim-and-fill method corresponds to an unknown implicit model generated by the symmetry assumption, whereas the Copas selection model is a parametric statistical model. However, it requires a sensitivity analysis. Regression-based approaches are easier to implement and not based on a specific selection model. Both simulations and applications suggest that in the presence of strong selection both the trim-and-fill method and the Copas selection model may not fully eliminate bias, while regression-based approaches seem to be a promising alternative. 相似文献
11.
12.
Michael N. Bruton Sheila E. Coutouvidis Jean Pote 《Environmental Biology of Fishes》1991,32(1-4):403-433
Synopsis A list of published references on the coelacanth Latimeria chalumnae is provided. All known publications in the scientific literature are included as well as popular articles and press reports that are considered to provide new information or interpretations. Marked trends are noticeable in the literature as different disciplines have been applied to research on the coelacanth over the past five decades. The bibliography lists a total of 823 publications including 490 papers in journals, 37 books, 3 theses, 45 chapters in books, 166 popular articles, 22 reports and 60 newspaper articles. Studies on taxonomy and morphology initially dominated the literature followed by reports on research in the fields of physiology, behaviour, breeding biology, ecology and conservation as frozen and eventually live specimens became available for study. The literature on the living coelacanth is predominantly in English, French, Japanese and German but references in 12 other languages were also traced. The dominant authors in the first decades of coelacanth research were the French scientists J. Millot and J. Anthony and the South African describer of the first and second coelacanths, J.L.B. Smith. In subsequent years French, British, American, South African, Japanese, Canadian and German authors, among others, have made significant contributions. 相似文献
13.
Independence of the five Papio species is evaluated. Baboons appear to be more similar to man than are other monkey species, which makes them a desirable model for use in experimental research to approximate human health conditions. They are, however, used less widely than macaques. Publications on baboons account for 10.3% of literature on the use of primates in experimental research. Baboons were most intensively used in surgery, then in hematology, cardiology, endocrinology. They were most rarely used in stomatology and in studies on infectious diseases. 相似文献
14.
Long-term monitoring datasets provide a solid framework for ecological research. Such a dataset from the German long-term ecological research (LTER) site Rhine-Main-Observatory was used to set up a species distribution model (SDM) for the Kinzig catchment. The extensive knowledge on the monitoring data provided by the LTER-site framework allowed to calibrate a robust model for 175 taxa of stream macroinvertebrates and to project their distributions on the Kinzig River stream network using bioclimatic, topographical, hydrological, land use and geological predictors. On average, model performance was good, with a TSS of 0.83 (±0.09 SD) and a ROC of 0.95 (±0.03 SD). The model delivered valuable insights on three sources of bias that plague SDMs in general: (a) level of taxonomic identification of the modeled organisms, (b) the spatial arrangement of sampling sites, and (c) the sampling intensity at each sampling site. Taxonomic resolution did not affect SDM performance. The distribution of high predicted probabilities of occurrence in the stream network coincided with those segments in the stream network most densely and frequently sampled, indicating both a spatial and temporal sampling bias. Species richness curves confirmed the temporal sampling bias. Next to spatial bias, sampling frequency also plays an important role in data collection, affecting further analysis and modeling procedures. Results indicate an underrepresentation of low order streams, an important aspect that should be addressed by both monitoring schemes and modeling approaches. 相似文献
15.
Carroll RJ 《Biometrics》2001,57(1):1-6
Using limited data, I argue that the review times in statistics are far too long for the field to keep pace with the rapidly changing environment in science. I note that statisticians do not appear to believe in statistics because data on the review process are not widely available to members of the profession. I suggest a few changes that could be made to speed up the review process, although it would appear that a change in our culture is required before the problem will be solved. 相似文献
16.
Results of case–control studies of mobile phone use and acoustic neuroma have been inconsistent. We conducted a case–case study of mobile phone use and acoustic neuroma using a self‐administered postal questionnaire. A total of 1589 cases identified in 22 hospitals throughout Japan were invited to participate, and 787 cases (51%) actually participated. Associations between laterality of mobile phone use prior to the reference dates (1 and 5 years before diagnosis) and tumor location were analyzed. The overall risk ratio was 1.08 (95% confidence interval (CI), 0.93–1.28) for regular mobile phone use until 1 year before diagnosis and 1.14 (95% CI, 0.96–1.40) for regular mobile phone use until 5 years before diagnosis. A significantly increased risk was identified for mobile phone use for >20 min/day on average, with risk ratios of 2.74 at 1 year before diagnosis, and 3.08 at 5 years before diagnosis. Cases with ipsilateral combination of tumor location and more frequently used ear were found to have tumors with smaller diameters, suggesting an effect of detection bias. Furthermore, analysis of the distribution of left and right tumors suggested an effect of tumor‐side‐related recall bias for recall of mobile phone use at 5 years before diagnosis. The increased risk identified for mobile phone users with average call duration >20 min/day should be interpreted with caution, taking into account the possibilities of detection and recall biases. However, we could not conclude that the increased risk was entirely explicable by these biases, leaving open the possibility that mobile phone use increased the risk of acoustic neuroma. Bioelectromagnetics 32:85–93, 2011. © 2010 Wiley‐Liss, Inc. 相似文献
17.
18.
19.
The Role of Context-Dependent Mutations in Generating Compositional and Codon Usage Bias in Grass Chloroplast DNA 总被引:7,自引:0,他引:7
Morton BR 《Journal of molecular evolution》2003,56(5):616-629
Abstract
The influence of local base composition on mutations in chloroplast DNA (cpDNA) is studied in detail and the resulting, empirically
derived, mutation dynamics are used to analyze both base composition and codon usage bias. A 4 × 4 substitution matrix is
generated for each of the 16 possible flanking base combinations (contexts) using 17,253 noncoding sites, 1309 of which are
variable, from an alignment of three complete grass chloroplast genome sequences. It is shown that substitution bias at these
sites is correlated with flanking base composition and that the A+T content of these flanking sites as well as the number
of flanking pyrimidines on the same strand appears to have general influences on substitution properties. The context-dependent
equilibrium base frequencies predicted from these matrices are then applied to two analyses. The first examines whether or
not context dependency of mutations is sufficient to generate average compositional differences between noncoding cpDNA and
silent sites of coding sequences. It is found that these two classes of sites exist, on average, in very different contexts
and that the observed mutation dynamics are expected to generate significant differences in overall composition bias that
are similar to the differences observed in cpDNA. Context dependency, however, cannot account for all of the observed differences:
although silent sites in coding regions appear to be at the equilibrium predicted, noncoding cpDNA has a significantly lower
A+T content than expected from its own substitution dynamics, possibly due to the influence of indels. The second study examines
the codon usage of low-expression chloroplast genes. When context is accounted for, codon usage is very similar to what is
predicted by the substitution dynamics of noncoding cpDNA. However, certain codon groups show significant deviation when followed
by a purine in a manner suggesting some form of weak selection other than translation efficiency. Overall, the findings indicate
that a full understanding of mutational dynamics is critical to understanding the role selection plays in generating composition
bias and sequence structure. 相似文献
20.
Sultan Ayoub Meo 《Saudi Journal of Biological Sciences》2018,25(7):1278-1283
Writing and publishing a scientific paper in academic journals is a highly competitive, time-consuming stepwise process. The road to scientific writing and publication is rarely straightforward. Scientific writing has uniform format, which is perplexing for the novice science writers due to its inflexible anatomy (structure) and physiology (functions). Many obstacles are allied with the scientific writing path which can be minimized by applying some simple guidelines and practices. The scientific papers have an almost similar format but, original articles are divided into distinct sections and each segment contains a specific type of information. The basic anatomy of scientific papers is mainly comprised of the structure of the various components of a scientific paper, including title, abstract, introduction, methods, results, discussion, conclusion, acknowledgments and references. However, the physiology of a scientific paper is difficult to understand. Early career researchers and trainees may be less familiar with the various components of scientific papers. In this study, we applied an observational approach to describe the essential steps to facilitate the readers and writers to understand the basic characteristics, anatomy and physiology of writing the various sections of a scientific paper for an academic science journal. 相似文献