The Glyxosides from Curculigo orchiodes

Seven compounds have been isolaed from the roots of Curculigo orchioides. On the basis of spectral analysis,their structures were elucidated as 2,6-dimethoxy benzoic acid (A),orcinol glucopyranoside(B),curculigine A(C),curculigoside(D),24s,3β,11α,16,24-tetrahyaroxycycloartenol-3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside(E),24s,3β,11a,16β,24-tetrahydroxycycloartenol-3-O-β-d-glucopyranosyl(1→2)-β-D-glucopyranoside(F) and dancosterol(G). Saponin F is a new tritepenoid compound.     

齿棱茎小蒜-中国新记录种

Allium inutile Makino in Bot.Mag.Tokyo 12：104.1898．- Nothoscordum inutile(Makino)kitamura in Bot.Mag.Tokyo 59：35.1946．     

猴头菌子实体化学成分研究

利用柱色谱技术从猴头菌(Hercium erinaceus)干燥子实体的甲醇提取物中分离得到11个化合物,经波谱技术分别鉴定为:D-赤藓糖醇(1)、D-阿拉伯糖醇(2)、1-O-β-D-吡哺葡萄糖基-(2S,4E,8E,2'R)-2-N-(2'-羟基十六烷酰)-9-甲基-4,8-sphingadienine(3)、3β-羟基-麦角甾-5,7,22-三烯(4)、3β-羟基-5α,8α-过氧化麦角甾-6,22-二烯(5)、硬脂酸(6)、油酸(7)、hericenone F(8)、hericenone C (9)、hericenone E(10)和hericene A(11).研究结果表明,hericenones型酚类物质在猴头菌子实体中含量丰富,化合物3是从猴头菌子实体中首次分离得到的脑酰胺类物质.     

Steroid compounds from two pacific starfish of the genus <Emphasis Type="Italic">Evasterias</Emphasis>

Three new steroid glycosides (evasteriosides C, D, and E) along with six known compounds were isolated from two Pacific starfish of the genus Evasterias. Evasterioside C from E. retiferacollected from the Sea of Japan was identified as (20R, 22E)-3-O-(β-D-xylopyranosyl)-24-nor-5α-cholest-22-ene-3β,6β,15α,26-pentaol 26-sulfate sodium salt. The structures of evasteriosides D and E from E. echinosoma (collected from the Gulf of Shelichov, the Sea of Okhotsk) were established as (20R, 24S)-24-O-(β-D-glucopyranosyl)-5α-cholestane-3β,6α,8,15β,24-pentaol and (20R,24S)-3,24-di-O-(β-D-xylopyranosyl)-cholest-4-ene-3β,6β,8,15α,24-pentaol, respectively. In addition, the known compounds pycnopodiosides A and C, luridoside A, 5α-cholestane-3β,6α,8,15β,16β,26-hexaol. 5α-Cholestane-3β,6α,8,15β,24-pentaol 24-sulfate sodium saltand marthasterone sulfate sodium salt were identified in E. echinosoma. The structures of the isolated compounds were established on the basis of spectroscopic analyses, using 1D and 2D NMR techniques, mass spectrometry, and some chemical transformations.     

肋果茶中的萜类化学成分研究

从肋果茶(Sladenia celastrifolia)95％乙醇提取物的乙酸乙酯部位中分离得到15个萜类化合物,经波谱学方法分别鉴定为sladeniafolin A(1),grasshopper ketone (2),(3S,5R,6S,7E,9R) -7-megastigmene-3,6,9-triol (3),hedytriol (4),(3S,5R,6R,7E,9R) -3,5,6,9-tetrahydroxy-7-megastigmene(5),1′S*,4′R*-8-(4′-hydroxy-2′,6′,6′-trimethylcyclohex-2-enyl)-6-methyloct-3E,5E,7E-trien -2-one (6),2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid (7),2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid(8),pomolic acid(9),3-O-acetyl pomolic acid(10),ursaldehyde (11),camarolide (12),3β-hydroxyurs-11-en-13β(28) -olide (13),3β-hydroxy -11α,12α-epoxy-urs-13β,28-olide (14)和28-0-β-D-glucopyranosyl euscaphic acid (15).以上化合物均首次从该植物中分离得到,其中1为新的C9裂环烯醚萜.     

中草药玄参化学成分的研究

从中草药玄参Scrophularia ningpoensis Hemsl.的乙醇溶液中分离得到14个化合物,根据理化性质和光谱数据分析分别鉴定为柳杉酚(1)、β-谷甾醇(2)、羽扇豆醇(3)、熊果酸(4)、鼠李糖(5)、胡萝卜苷(6)、蔗糖(7)、咖啡酸(8)、油酸(9)、3-O-(6’-O-palmitoyl-β-D-glucosyl)-spinasta-7,22-diene(10)、clematomanshurica saponin E(11)、α-caryphy(12)、雪松醇(13)和Scrophuloside A4(14)。其中化合物3,58,～14均为首次从玄参中分离得到。     

黑柄炭角菌的化学成分

从黑柄炭角菌(Xylaria nigripe)子实体中分离得到10个化合物,通过波谱分析等方法分别鉴定为(22E,24R)-麦角甾-5,7,22-三烯-3β-醇(1)、5α,8α-过氧-(22E,24R)-麦角甾-6,22-二烯-3β-醇(2)、脑苷酯B(3)、脑苷酯D(4)、stearic acid(5)、甘油的亚油酸三酯(trilinolein,6)、α-kojibiose(7)、D-阿洛糖醇(8)、L-氨基丙酸(9)和尿囊素(10)。所有化合物均为首次从该子实体中分离得到。     

三种毒菌的化学成分研究

本文对三种毒菌的化学成分进行了研究。从光盖伞(Psilocybe spp)分离鉴定了4个化合物,经波谱分析鉴定为:(22E,24R)-麦角甾-7,22-二烯-3β-十八烷酸酯(1)、β-胡萝卜苷(2)、(22E,24R)-5α,6α-环氧麦角甾-8,22-二烯-3β,7α-二醇(3)、色氨酸(4);从假褐云斑鹅膏(Amanita pseudoporphyria)分离鉴定了4个化合物:(22E,24R)-3β-羟基-5α,8α-过氧化麦角甾-6,22-二烯(5)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(6)、1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基棕榈酰)-9-甲基-4,8-脱氢鞘氨醇(7)、1-O-β-D-吡喃葡萄糖基-(2S,3R,4E,8E,2′R)-2-N-(2′-羟基十八烷酰)-9-甲基-4,8-脱氢鞘氨醇(8);大青褶伞(Chlorophyllum molybdites)发酵菌丝体分离鉴定了4个化合物:5、6、(22E,24R)-5α,6α-环氧麦角甾-8(14),22-二烯-3β,7α-二醇(9)、(22E,24R)-麦角甾-7,22-二烯-3β-醇(10)。除化合物9外其它化合物均为首次从以上相应毒菌中分离得到。     

蓝柄丽齿菌的化学成分

从担子菌亚门蓝柄丽齿菌(Calodon suaveolens)中首次分离得到8个化合物,通过波谱学技术并借助必要的化学方法最终确定结构,它们是：(22E,24R)-麦角甾-7,22-二烯-3β-醇(1),(22E,24R)-5α,8α-过氧麦角甾-6,22-二烯．3β-醇(2),(22E,24R)-麦角甾．5,7,22-三烯-3β-醇(3),(22E,24R)-3β-羟基麦角甾-5,22-二烯-7-酮(4),对羟基苯甲酸(5),尿嘧啶(6),polyozellin(7),(4E,BE）-2-N-(2’-羟基棕榈酰)-1-O-β-D-吡喃葡萄糖基-9-甲基-4,8-sphingadienine(8)。     

裂褶菌化学成分研究

经硅胶反复柱层析,从裂褶菌子实体的醇提物中首次分离得到8个化合物,利用波谱方法及理化性质鉴定为5,α8α-过氧麦角甾-6,22E-二烯-3β-醇(1)、麦角甾-7,22-二烯-3β醇(2)、(22E,24R)-麦角甾-7,22-二烯-3β,5α,6β-三醇(3)、烟酸(4)、苯甲酸(5)、D-阿拉伯糖醇(6)、甘露醇(7)、海藻糖(8)。     

尼泊尔水东哥的化学成分研究

从尼泊尔水东哥树皮的95%乙醇提取物中首次分离到12个化合物,应用波谱方法或与已知品对照的手段鉴定为auranamide(1)、aurantiamide benzoate(2)、齐墩果酸(3)、β-谷甾醇(4)、β-胡萝卜甙(5)、乌苏酸(6)、2α,3α-二羟基-12-烯-28-乌苏酸(7)、2α,3β,24-三羟基-12-烯-28-乌苏酸(8)、(2S,3S,4R,10E)-2-[(2′R)-2′-hydroxytetracosanoylamino]-10-octadecene-1,3,4-triol(9)、2α,3α,24-三羟基-12-烯-28-齐墩果酸(10)、2α,3β-二羟基-12-烯-28-乌苏酸(11)和2α,3α,24-三羟基-12-烯-28-乌苏酸(12)。     

Cytotoxic steroids from Monascus purpureus-fermented rice

Bioassay-guided fractionation of an EtOH extract of Monascus purpureus-fermented rice led to the isolation of two new steroids (22S, 23R, 24S)-20β,23α,25α-trihydroxy-16,22-epoxy-4,6,8(14)-trienergosta-3-one (1), the first example of a steroid possessing both a conjugated triene ketone system and a fused 4H-furan ring side chain within one molecule, and (22E, 24R)-3β,5α-dihydroxyergosta-23-methyl-7,22-dien-6-one (2), as well as two known compounds (22E, 24R)-3β,5α-dihydroxyergosta-7,22-dien-6-one (3) and (22E, 24R)-6β-methoxy-ergosta-7,22-diene-3β,5α-diol (4). Their structures were assigned by detailed interpretation of HRESIMS, 1D and 2D NMR spectroscopic data. The absolute stereochemistry of 1 was determined by single-crystal X-ray crystallography while the absolute stereochemistry of 2 was established by CD. Compounds 1-4 showed cytotoxic activity against the lung adenocarcinoma (A549) with IC(50) values of 0.08, 0.94, 12.6 and 13.5 μM, respectively. In addition, compounds 1 and 2 exhibited moderate activities against human ovarian cancer (A2780), with IC(50) values of 2.8 and 5.1 μM.     

小金梅草化学成分研究(英文)

从小金梅草乙醇提取物中分离得到了12个化合物,分别为3-O-β-D-槲皮素葡萄糖苷(1)、3-O-β-D-山柰酚葡萄糖苷(2)、5-O-β-D-芹菜素葡萄糖苷(3)、α-菠甾醇(4)、2,6-二甲氧基苯甲酸(5)、3-吲哚甲酸(6)、(2S,3R,4E,8E)-1-(β-D-吡喃葡萄糖苷)-N-[(R)-2’-羟基-二十碳酰基]-9-甲基-4,8-二烯-1,3-二醇-2-氨基-十八烷(7)、正三十二烷醇(8)、14,15-二十碳烯酸(9)、木腊酸(10)、β-谷甾醇(11)、胡萝卜苷(12)。以上化合物均为首次从该植物中得到。     

攀援孔药花化学成分研究

从攀援孔药花全草95%乙醇提取物中首次分离得到19个化合物,通过波谱数据或与已知物对照,它们分别鉴定为:(2S,3S,4R)-2-[(2R)-2-羟基-二十一酰胺基]-二十一烷-1,3,4-三醇(1)、(2S,3S,4R)-2-二十四酰胺基-十八烷-1,3,4-三醇(2)、胡萝卜甙(3)、β-谷甾醇(4)、(20S,22E,24R)-5α,8α-表二氧-麦角甾-6,22-二烯-3β-醇(5)、6β-羟基-豆甾-4-烯-3-酮(6)、十六烷酸-1-甘油酯(7)、桦木酸(8)、大黄素(9)、二十二烷酸-1-甘油酯(10)、对羟基苯甲醛(11)、十七烷酸-1-甘油酯(12)、金色酰胺醇乙酸酯(13)、十九烷酸-1-甘油酯(14)、棕榈酸(15)(、E)-p-香豆酸(16)、(22E,24S)-24-甲基-5α-胆甾-7,22-二烯-3β,5α,6β-三醇(17)、2-去氧-β-蜕皮激素(18)和auranamide(19)。     

中华青荚叶的一个新果糖酯

从山茱萸科中华青荚叶( Helwingia chinensis )的乙醇提取物中分离得到一个新果糖酯和十个已知化合物.通过现代波谱技术分别鉴定为:2- O -(E)-咖啡酰-3- O -(3, 5-二甲氧基香豆酰)-α-D-呋喃果糖甙(1),2- O -β-D-呋喃果糖基α-D-异吡喃糖酯(2),甘草甜素(3),4′-羟基-7- O -葡萄糖-2, 3-二羟黄酮甙(4),黄豆甙(5),5-葡萄糖芹菜甙(6),7- O -葡萄糖芹菜甙(7),4- O -葡萄糖香豆酸(8), 葡萄糖咖啡酸(9), 3β-赤杨醇(10), 薯蓣皂甙3- O -{α-L-鼠李糖吡喃糖基(1→2)-[α-L-阿拉伯呋喃糖基(1→3)]-β-D-葡萄糖吡喃糖} (11).     

Chemical Constituents of Siegesbeckia orientalis L.

The aerial parts of Siegesbeckia have been used as the traditional Chinese medicine in the treatment of rheumatic arthritis, hypertension, malaria, neurasthenia, and snakebite. In order to find new and bioactive compounds, the chemical constituents of the aerial parts of S. orientalis L. were investigated and two new compounds, namely β-D-glucopyranosyl-ent-2-oxo-15,16-dihydroxy-pimar-8（14）-en-19-oic-late （compound 1 ） and [1 （10） E,4Z]-8β-angeloyloxy-9α-methoxy-6α, 15-dihydroxy-14-oxogermacra-1 （10）,4,11 （13）-trien-12-oic acid 12,6-1actone （compound 2）, as well as five known ent-pimarane diterpenes （compounds 3-7） were isolated. The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly oneand two-dimensional nuclear magnetic resonance spectral methods.     

Secondary metabolites from two species of Pulicaria and their cytotoxic activity

Two new compounds, the sesquiterpene (1E,5E)-8β-acetoxy-4α-hydroxy-7βH-germacra-1(10),5-dien-14-oic acid (2), and a nor-sesquiterpene, (5E)-8β-acetoxy-4α-hydroxy-7βH-germacr-5-en-10-one (3), were isolated from Pulicaria canariensis ssp. lanata, along with ten known compounds, including the flavonoid 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (4). From Pulicaria burchardii, we isolated seven known compounds; the physical and spectroscopic data of the triterpenoid 3β-hydroxytaraxaster-20-en-30-al (1) are reported. The structures of compounds 1-3 were determined on the basis of HR-MS, and 1D- and 2D-NMR studies. The structure of 2 was corroborated by X-ray crystal diffraction. Cell viability experiments revealed that the semisynthetic flavonoid 4b was the most cytotoxic compound against human leukemia cells, and the cytotoxicity was caused by induction of apoptosis, as determined by microscopy of nuclear changes.     

黑蛞蝓化学成分研究(Ⅱ)

为研究中药材黑蛞蝓(Agriolimax agrestis)的化学成分及其化合物的α-糖苷酶抑制活性,本研究采用Sephadex LH-20、硅胶、Chromatorex C₁₈等柱色谱对黑蛞蝓正己烷提取物进行化学成分离纯化,通过NMR波谱数据与文献对比分析鉴定化合物结构。从黑蛞蝓正己烷提取物中共分离得到15个化合物,分别鉴定为苯乙醇(1)、十六烷酸(2)、(Z) 9-octadecenoic acid(3)、1-(2-hydroxyethoxy)ethyl (E)-octadec-9-enoate(4)、二十七烷(5)、dodecyl (Z)-9-hexadecenoate(6)、cis,cis-diunsaturated α-meromycolic acid(7)、1,2,3-propanetriyl (9Z,9′Z,9″Z)tris(-9-octadecenoate)(8)、胆固醇(9)、7-酮基胆固醇(10)、胆甾-5-烯-3β,7α二醇(11)、胆甾-5-烯-3β,7β二醇(12)、胆甾醇肉豆蔻酸酯(13)、胆甾醇基十七酸酯(14)、熊果酸(15)。除化...     

Cytotoxic terpenoids from Juglans sinensis leaves and twigs

Bioassay-guided fractionation of an 80% MeOH extract of Juglan sinensis leaves and twigs has resulted in the isolation of three new triterpenes (1-3) and two new sesquiterpenes (4-5) along with two known sesquiterpenes (6-7). The new compounds were determined to be 3β, 11α, 19α, 24, 30-pentahydroxy-20β, 28-epoxy-28β-methoxy-ursane (1), 1α, 3β-dihydroxy-olean-18-ene (2), 2α, 3α, 23-trihydroxy-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (3), (4S, 5S, 7R, 8R, 14R)-8, 11-dihydroxy-2, 4-cyclo-eudesmane (4), 15-hydroxy-α-eudesmol-11-O-β-d-glucopyranoside (5), by spectroscopic analysis. The cytotoxicity of compounds (1-7) against four cancer cell lines such as B16F10, Hep-2, MCF-7 and U87-MG was evaluated. Compounds 1, 2, 6 and 7 showed potent cytotoxicity against all of four cancer cell lines, respectively.     

南海疏枝刺柳珊瑚中甾醇类化合物的研究

本文对采自海南三亚海域的疏枝刺柳珊瑚(Echinogorgia pseudossapo)化学成分进行研究,分离到11个甾醇类化合物。经波谱数据分析,分别鉴定为cholest-5-en-3β-ol(1),24-methylene-cholest-4-ene-3β,6β-diol(2),24-norcholesta-22-en-3β-ol(3),acanthovagasteroid A(4),calicoferol E(5),calicoferol F(6),6-hydroxy-cholest-4-ene-3-one(7),echinoflorasterol(8),echissaposterol(9),24-methylcholest-5-en-3β,7α-diol(10)和24-methylcholest-5,22(E)-dien-3β,7α-diol(11)。除化合物8外,其余化合物均首次从该种海洋动物中分离得到。