共查询到20条相似文献,搜索用时 31 毫秒
1.
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ambrose Z Palmer S Boltz VF Kearney M Larsen K Polacino P Flanary L Oswald K Piatak M Smedley J Shao W Bischofberger N Maldarelli F Kimata JT Mellors JW Hu SL Coffin JM Lifson JD KewalRamani VN 《Journal of virology》2007,81(22):12145-12155
2.
3.
Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Villena C Prado JG Puertas MC Martínez MA Clotet B Ruiz L Parkin NT Menéndez-Arias L Martinez-Picado J 《Journal of virology》2007,81(9):4713-4721
4.
5.
6.
7.
8.
9.
10.
Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy 总被引:1,自引:0,他引:1
Kearney M Spindler J Shao W Maldarelli F Palmer S Hu SL Lifson JD KewalRamani VN Mellors JW Coffin JM Ambrose Z 《Journal of virology》2011,85(2):1067-1076
11.
12.
13.
Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Imamichi T Berg SC Imamichi H Lopez JC Metcalf JA Falloon J Lane HC 《Journal of virology》2000,74(23):10958-10964
14.
15.
16.
Andreola ML Pileur F Calmels C Ventura M Tarrago-Litvak L Toulmé JJ Litvak S 《Biochemistry》2001,40(34):10087-10094
17.
Micheva-Viteva S Kobayashi Y Edelstein LC Pacchia AL Lee HL Graci JD Breslin J Phelan BD Miller LK Colacino JM Gu Z Ron Y Peltz SW Dougherty JP 《The Journal of biological chemistry》2011,286(24):21083-21091
Current antiretroviral therapy (ART) provides potent suppression of HIV-1 replication. However, ART does not target latent viral reservoirs, so persistent infection remains a challenge. Small molecules with pharmacological properties that allow them to reach and activate viral reservoirs could potentially be utilized to eliminate the latent arm of the infection when used in combination with ART. Here we describe a cell-based system modeling HIV-1 latency that was utilized in a high-throughput screen to identify small molecule antagonists of HIV-1 latency. A more detailed analysis is provided for one of the hit compounds, antiviral 6 (AV6), which required nuclear factor of activated T cells for early mRNA expression while exhibiting RNA-stabilizing activity. It was found that AV6 reproducibly activated latent provirus from different lymphocyte-based clonal cell lines as well as from latently infected primary resting CD4(+) T cells without causing general T cell proliferation or activation. Moreover, AV6 complemented the latency antagonist activity of a previously described histone deacetylase (HDAC) inhibitor. This is a proof of concept showing that a high-throughput screen employing a cell-based model of HIV-1 latency can be utilized to identify new classes of compounds that can be used in concert with other persistent antagonists with the aim of viral clearance. 相似文献
18.
19.
Genotypic, phenotypic, and modeling studies of a deletion in the beta3-beta4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Winters MA Coolley KL Cheng P Girard YA Hamdan H Kovari LC Merigan TC 《Journal of virology》2000,74(22):10707-10713