英特网与昆虫学研究的信息资源

在对英特网（Ｉｎｔｅｒｎｅｔ）计算机网络及其所能提供的服务的基础上,着重介绍了利用目前流行的两个工具软件Ｎｅｔｓｃａｐｅ和Ｉｎｔｅｒｎｅｔ ｉｎ ａ ＢＯＸ在网上获取有关昆虫学研究信息资源的方法;同时,还介绍了网上世界范围内有关昆虫学研究信息服务站点和所涉及的具体内容、获取这些信息的地址等。这对昆虫学家们有效访问Ｉｎｔｅｒｎｅｔ信息资源,将有很大帮助。     

Internet: a major resource for toxicologists

Use of the Internet in developing countries is now growing faster. Internet has created a new conduit not only for communication but also in the access, sharing and exchange of information among scientists. The Internet is now viewed as the world's biggest library where retrieval of scientific literature and other information resources are possible within seconds. Large volumes of toxicological information resources are available on the Internet. This review outlines some sites that may be of great importance and useful to the toxicologist.     

GrainGenes 2.0. an improved resource for the small-grains community

GrainGenes (http://wheat.pw.usda.gov) is an international database for genetic and genomic information about Triticeae species (wheat [Triticum aestivum], barley [Hordeum vulgare], rye [Secale cereale], and their wild relatives) and oat (Avena sativa) and its wild relatives. A major strength of the GrainGenes project is the interaction of the curators with database users in the research community, placing GrainGenes as both a data repository and information hub. The primary intensively curated data classes are genetic and physical maps, probes used for mapping, classical genes, quantitative trait loci, and contact information for Triticeae and oat scientists. Curation of these classes involves important contributions from the GrainGenes community, both as primary data sources and reviewers of published data. Other partially automated data classes include literature references, sequences, and links to other databases. Beyond the GrainGenes database per se, the Web site incorporates other more specific databases, informational topics, and downloadable files. For example, unique BLAST datasets of sequences applicable to Triticeae research include mapped wheat expressed sequence tags, expressed sequence tag-derived simple sequence repeats, and repetitive sequences. In 2004, the GrainGenes project migrated from the AceDB database and separate Web site to an integrated relational database and Internet resource, a major step forward in database delivery. The process of this migration and its impacts on database curation and maintenance are described, and a perspective on how a genomic database can expedite research and crop improvement is provided.     

Development of an Internet Web Application for the Study of Surface Plasmon Resonance Spectroscopy

Plasmonics - An online web application was developed for the study of surface plasmon resonance (SPR) of different materials using angular and wavelength modulation. The present web application...     

The academic medical centre: an idea whose time has come.

Interdependence of faculties of medicine or health sciences and teaching hospitals is central to the academic medical centre''s three "products": education, research and clinical service. Whether a voluntary association, partnership, joint venture or single entity, the strength of the association of member institutions must lie in mutual dependency. With the potential of reducing costs and increasing effectiveness through administrative efficiency and rationalization, especially of planning and setting priorities, the academic medical centre can outstrip its individual member institutions in contributing to the solution of Canada''s present and future challenges in health care.     

基于Internet网生物信息资源特定基因同源新基因克隆策略

随着人类基因组计划的基本完成,各类生物信息学数据库和软件层出不穷,利用Internet网上生物信息资源克隆新基因的策略也得到新的发展。作者在简单介绍网上生物信息资源以及新基因克隆策略的同时,着重对基于EST数据库和基因组数据库特定基因的同源新基因克隆策略进行了详细阐述。     

Development and perspectives of scientific services offered by genomic biological resource centres.

A number of fundamental technical developments like the evolvement of oligonucleotide microarrays, new sequencing technologies and gene synthesis have considerably changed the character of genomic biological resource centres in recent years. While genomic biological resource centres traditionally served mainly as providers of sparsely characterized cDNA clones and clone sets, there is nowadays a clear tendency towards well-characterized, high-quality clones. In addition, major new service units like microarray services have developed, which are completely independent of clone collections, reflecting the co-evolution of data generation and technology development. The new technologies require an increasingly higher degree of specialization, data integration and quality standards. Altogether, these developments result in spin-offs of highly specialized biotech companies, some of which will take a prominent position in translational medicine.     

The Genome Sequence DataBase: towards an integrated functional genomics resource.

During 1998 the primary focus of the Genome Sequence DataBase (GSDB; http://www.ncgr.org/gsdb ) located at the National Center for Genome Resources (NCGR) has been to improve data quality, improve data collections, and provide new methods and tools to access and analyze data. Data quality has been improved by extensive curation of certain data fields necessary for maintaining data collections and for using certain tools. Data quality has also been increased by improvements to the suite of programs that import data from the International Nucleotide Sequence Database Collaboration (IC). The Sequence Tag Alignment and Consensus Knowledgebase (STACK), a database of human expressed gene sequences developed by the South African National Bioinformatics Institute (SANBI), became available within the last year, allowing public access to this valuable resource of expressed sequences. Data access was improved by the addition of the Sequence Viewer, a platform-independent graphical viewer for GSDB sequence data. This tool has also been integrated with other searching and data retrieval tools. A BLAST homology search service was also made available, allowing researchers to search all of the data, including the unique data, that are available from GSDB. These improvements are designed to make GSDB more accessible to users, extend the rich searching capability already present in GSDB, and to facilitate the transition to an integrated system containing many different types of biological data.     

Adaptive designs from the viewpoint of an academic biostatistician

This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'FDA's critical path initiative: A perspective on contributions of biostatistics' by Robert T. O'Neill, 'A regulatory view on adaptive/flexible clinical trial design' by H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence; and 'Confirmatory clinical trials with an adaptive design' by Armin Koch.     

Insect flotsam: an unstudied marine resource

Abstract. 1. Insect flotsam was obtained from marine pleuston samples from the English Channel (U. K.), off the Oregon coast (U. S. A.), and in the Gulf of California (Mexico).
2. Only ten orders of insects were represented, Coleoptera, Diptera and Homoptera being the most abundant.
3. Staphylinidae and Chironomidae were the most abundantly represented families taken from the English Channel, comprising 43% and 18% respectively of total insects sampled.
4. Aphididae comprised 39% of the Oregon Coast samples.
5. Aphididae (42%) and Cicadellidae (17%) accounted for 59% of the insects in the Gulf of California.
6. Fish may feed on surface insects at night and this may account for the lower numbers found in early morning samples.     

Financial control of laboratory animal facilities: partial cost recovery in an academic institution.

The objective of cost management in the animal house is to make efficient use of resources and to regulate the activity of the user. Regular charging of users keeps them aware of their responsibility both ethically and financially. Forward budgetary control is encouraged and regulation of the work load achieved through planned requirements helps to reduce animal wastage.