Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964

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Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients

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Structural basis of γ-secretase inhibition and modulation by small molecule drugs

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A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors

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Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy

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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

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2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

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Structural basis of Apt48 inhibition of the BCL6 BTB domain

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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DNA-PKcs promotes fork reversal and chemoresistance

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Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

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ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

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Inhibition of talin-induced integrin activation by a double-hit stapled peptide

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Paradoxical activation of c-Src as a drug-resistant mechanism

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In situ identification of cellular drug targets in mammalian tissue

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ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase,Fgr

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