The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

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Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites

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SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape

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Bi-allelic SNAPC4 variants dysregulate global alternative splicing and lead to neuroregression and progressive spastic paraparesis

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Genomic architecture of autism from comprehensive whole-genome sequence annotation

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Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2

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Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures

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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

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Bi-allelic variants in HMGCR cause an autosomal-recessive progressive limb-girdle muscular dystrophy

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Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

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TCEAL1 loss-of-function results in an X-linked dominant neurodevelopmental syndrome and drives the neurological disease trait in Xq22.2 deletions

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Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome

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The effect of spike mutations on SARS-CoV-2 neutralization

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Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis

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The genetic architecture of pediatric cardiomyopathy

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Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders

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Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

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SARS-CoV-2 breakthrough infections elicit potent,broad, and durable neutralizing antibody responses

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Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression

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An allelic-series rare-variant association test for candidate-gene discovery

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