Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30

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Targeted gene disruption in a marsupial,Monodelphis domestica,by CRISPR/Cas9 genome editing

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DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

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Structural basis for Cas9 off-target activity

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Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport,generating compositionally diverse Importin β-1 granules

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Structure and regulation of the microtubule plus-end tracking protein Kar9

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Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

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DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network

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Structural study of the N-terminal domain of human MCM8/9 complex

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

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Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9

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Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System

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Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

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Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope

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Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity

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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

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Cas9 deactivation with photocleavable guide RNAs

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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat

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