2011——2015年广安市居民碘营养状况监测结果分析

目的：了解广安市重点人群的碘营养状况,为指导科学补碘提供科学依据。方法：每年按PPS法监测重点人群尿碘水平、8～10岁儿童甲肿率,并在全市监测食用盐碘摄入情况,使用Excel和SPSS软件通过卡方检验、秩和检验对结果进行统计分析。结果：2011—2015年广安市居民食用盐碘含量中位数为26.93～30.63mg/kg;8～10岁儿童甲肿率触诊法检测结果为0%～4.18%（2011—2015年）,B超法检测结果为2013年0.25%、2014年1.25%;8～10岁儿童、孕妇、哺乳期妇女、婴幼儿、40岁以下育龄妇女尿碘水平中位数分别为231.2～300.6μg/L、144.6～278.3μg/L、182.1～209.1μg/L、186.4～255.1μg/L、160.7～236.4μg/L;8～10岁儿童、孕妇、40岁以下育龄妇女碘营养超量率分别为26%～42%、26%～44%、26%～40%,过量率分别为24%～50%、6%～12%、16%～28%。结论：2011—2015年广安市已经达到消除碘缺乏病的标准,但部分人群又出现了碘摄入超过适宜量的现象,应根据具体情况指导居民科学食用碘盐。     

晨尿AD7c-NTP水平与轻度认知障碍之间的关系

目的:探讨老年男性晨尿阿尔茨海默病相关神经丝蛋白(AD7c-NTP)水平与轻度认知障碍(MCI)发病之间关系。方法:收集341例住院老年男性患者中段晨尿,采用双抗体夹心法测定尿液AD7c-NTP浓度。同时,对患者进行痴呆系列测试、行头颅CT和(或)MRI检查。根据测试结果剔除20例早老性痴呆患者,剩余321例患者根据测试及检查结果分为对照和MCI组,两组病例数分别为270例和51例,分析尿液AD7c-NTP浓度与年龄和MCI发病之间关系。结果:老年男性晨尿AD7c-NTP浓度呈偏态分布,测定结果中位数为0.475μg/L(0.001μg/L-8.85μg/L);对照组年龄76.0±9.0岁,AD7c-NTP测定结果中位数为0.467μg/L(0.001μg/L-8.85μg/L);MCI组51例年龄85.7±8.2岁,AD7c-NTP测定结果中位数为0.862μg/L(0.10μg/L-8.20μg/L);两组年龄之间存在显著差异(P=0.000);晨尿AD7c-NTP浓度与年龄的Spearman相关系数为0.267(P=0.00)。未考虑年龄影响时,两组ln(AD7c-NTP)之间差异有显著(P=0.041);考虑年龄影响后,两组ln(AD7c-NTP)之间差异显著性消失(P=0.604)。结论:晨尿AD7c-NTP浓度与年龄相关,AD7c-NTP与MCI发病之间关系需进一步研究。     

高原寒环境暴露对急进入高原健康人群肾功能的影响

目的:探讨高原低压低氧寒环境对急进高原的平原健康人群肾功能的影响。方法:选取30例长期居住兰州地区急进高原(海拔3300米、日平均气温-4度)健康人群,对比分析所有受试者进驻高原前和进驻高原后第24 h、72 h、7天、14天、28天尿IL-18(白介素-18)、尿NAGL(中性粒细胞明胶酶相关性脂质运载蛋白)、尿KIM-1(肾损伤因子-1)及血肌酐水平的变化。结果:共28人完成全部6次尿液及血标本采集并检测,其中2名女性因某次采集点处于月经期剔除,其中男性17人、女性11人,平均年龄26.8±3.2岁(男性28.3±4.2岁,女性24.8±2.6岁)。进入高原前和进驻高原后第24 h、72 h、7天、14天、28天尿IL-18检测值分别为3.62±0.32 ng/L、11.20±0.65 ng/L(P<0.001,较进入前组比较)、6.32±0.46 ng/L(P<0.001)、4.36±0.68 ng/L(P<0.05)、3.58±0.71 ng/L、3.32±0.46 ng/L;尿NAGL水平分别为0.126±0.20μg/L、0.513±0.003μg/L(P<0.001)、0.116±0.006μg/L、0.009±0.001μg/L、0.121±0.010μg/L、0.632±0.009μg/L;尿KIM-1水平分别为2.61±0.22 ng/L、18.20±0.69 ng/L(P<0.001)、6.32±0.46 ng/L(P<0.001)、6.36±0.68 ng/L(P<0.001)、2.58±0.31 ng/L、2.32±0.26 ng/L;血肌酐水平分别为61.0±9.16μmol/L、58.5±8.13μmol/L、80.3±10.38μmol/L(P<0.05)、76.5±12.04μmol/L(P<0.05)、62.6±10.14μmol/l、62.3±8.18μmol/L。结论:急进高原健康入群早期肾功能有改变,其中尿IL-18、尿KIM-1、尿NAGL水平较血肌酐水平变化更早、更敏感。     

大连市沙河口区孕妇尿碘水平追综调查结果分析

目的评价全民食盐加碘防治碘缺乏病效果。方法选择补碘重点人群孕妇,要求孕妇年龄〈30岁,进行尿碘检测。结果各年度尿碘中位数均达到或超出孕妇尿碘适宜水平。结论调整全民食盐加碘浓度使重点人群碘营养合理化。     

罗汉果组培繁殖的技术要点

报道罗汉果组培繁殖的各项主要技术要点,包括组培条件、培养基的配制、外植体的选取与消毒、接种与培养、种源保存、炼苗与移栽、苗木包装与运输等。提出了5种培养基参考配方,即茎段诱导培养:MS+BA0.5～1.0mg/L+IAA(NAA)0.05～0.1mg/L+白糖3%+琼脂4.5g/L,pH5.8;茎尖诱导培养:MS+BA0.5～1.0mg/L+NAA0.05～0.1mg/L+椰子水100mL+白糖3%+琼脂4.5mg/L,pH5.8;继代培养(丛生芽方式):MS+BA0.3～0.7mg/L+NAA0.05/IAA0.1mg/L+白糖3%+琼脂4.5mg/L,pH5.8;继代培养(微型扦插方式):MS+BA0.1mg/L+IAA0.3mg/L+活性炭0.07g/L+白糖3%+琼脂4.5mg/L,pH5.8;生根培养:MS+BA0.07mg/L+IBA0.15mg/L+IAA0.1mg/L+活性炭0.1g/L+白糖3%+琼脂4.5mg/L,pH5.8。分析了外植体培养过程中可能出现的不良状况的原因并提出预防措施,明确了炼苗移栽的适宜条件并制定出相应的管理方法。形成了一套较为完整的罗汉果组培苗繁殖生产技术规程。     

皮质酮诱导的PC12细胞梯度应激损伤模型的构建及评价

目的:建立皮质酮诱导的PC12细胞梯度应激损伤模型,为细胞应激水平的评估和细胞应激损伤调控研究提供实验基础和对象。方法:通过检测不同浓度皮质酮(0～1 000μmol/L)在经过不同干预时间(8～48 h)后PC12细胞活力,观察皮质酮对细胞活力的影响,筛选最佳干预条件的细胞模型。分光光度法和微量法检测细胞模型的关键应激指标(MDA、SOD、NADH、LDH),对模型进行评价。结果:当皮质酮浓度在200μmol/L以下且干预时间为12 h时,细胞活力在半数失活率以下,可减少各组由于细胞活力下降而产生的混杂因素。与空白对照组比较,皮质酮浓度依赖性地升高模型组的MDA、NADH和LDH水平,降低SOD水平(P<0.01),符合梯度应激模型的构建要求。结论:成功建立了PC12细胞梯度应激损伤模型,在干预时间为12 h的情况下,干预浓度为0μmol/L、25μmol/L、50μmol/L、100μmol/L、150μmol/L、200μmol/L,使得细胞模型应激损伤程度梯度增加,可作为开展细胞应激损伤评估及调控实验的基础和对象。     

HPLC法同时测定柠檬中6种水溶性维生素含量

本研究以7个不同品种柠檬为材料,采用高效液相色谱(HPLC)法对不同品种柠檬中6种水溶性维生素(VB1、VB3、VB6、VB9、VB12和VC)含量进行同时测定。样品前处理后,经Agilent Zorbax Eclipse XDB-C18色谱柱(250 mm×4.6 mm,5μm)分离,以0.1%磷酸水溶液(A)-乙腈(B)为流动相进行梯度洗脱,流速为0.9 m L/min;柱温为30℃,在波长267 nm处检测。结果表明,6种水溶性维生素在17 min内完全分离,在0.06~49.60μg/m L(R~2=0.9999~1.0000)呈良好的线性关系,检出限为0.03~0.27μg/m L,定量限为0.08~0.82μg/m L,平均回收率为99.06%~101.72%,RSD为0.49%~0.98%。进一步用该方法对7个不同品种柠檬样本进行检测,结果显示柠檬样本中VC含量远高于B族维生素含量,S_NM中VC含量最高(57.96±0.56 mg/100 g),EUR_D中VC含量最低(27.37±0.27 mg/100 g)。主成分分析揭示了不同柠檬果汁中水溶性维生素的相似性和差异性。S_NM的综合评价指数高于其他6个样品且EUR_D的综合评价指数远低于EUR_C和EUR_Y。该方法操作简单,精密度、重复性、稳定性好及回收率高,可有效检测柠檬中多种水溶性维生素的含量;7个品种柠檬果汁中维生素含量差异显著;主成分值可为柠檬中维生素指标提供理论依据。     

甲型H1N1流感病毒裂解疫苗的免疫原性和安全性

目的评价甲型H1N1流感病毒裂解疫苗(简称甲型H1N1流感疫苗)的免疫原性和安全性。方法按照随机、双盲、安慰剂对照的原则,采用0、21天免疫程序,选择3岁及3岁以上健康者1 202人。分组为3~11岁、12~17岁、≥60岁组,按照人数基本为1∶1的比例随机分别接种7.5μg和15.0μg甲型H1N1流感疫苗;18~59岁组按照人数基本为1∶1∶1的比例随机分别接种7.5μg、15.0μg甲型H1N1流感疫苗和安慰剂对照。观察各组接种后的不良反应率以及免疫前后血凝抑制(HI)抗体阳转率、保护率、GMT水平和平均增长倍数。结果受试对象的安全性结果显示7.5μg和15.0μg组不良反应发生率分别为8.74%(48/549)和13.88%(74/533),其中Ⅱ级反应率分别为0.36%(2/549)和1.13%(6/533),未观察到Ⅲ级及以上不良反应和其他异常反应及严重不良事件。2剂接种未见不良反应叠加现象。7.5μg或15.0μg试验疫苗首剂免疫后,血清抗体阳性率分别为85.13%(395/464)和90.77%(413/455),保护率分别为85.56%(397/464)和91.43%(416/455),抗体GMT较免疫前分别增长36.1倍和52.6倍。2剂免疫后,血清抗体阳性率分别是97.84%(454/464)和99.12%(451/455),保护率分别是98.06%(455/464)和9 9.56%(453/455),抗体GMT较免疫前分别增长63.3倍和96.0倍。4个年龄组(3~11岁、12~17岁、18~59岁及≥60岁年龄组)7.5μg和15.0μg组HI抗体阳性率和保护率均大于70%,GMT较免疫前均增长2.5倍以上,结果显示7.5μg和15.0μg甲型H1N1流感疫苗接种1剂后抗体水平已达到研究方案中设定的预期标准,免疫2剂后抗体阳性率和抗体水平明显提高。结论临床试验表明甲型H1N1流感疫苗具有良好的安全性和免疫原性,且接种1剂15.0μg甲型H1N1流感疫苗,即可在3岁和3岁以上人群中产生良好的免疫效果。     

福建野生紫芝资源开发利用Ⅱ．“闽紫96”(中国灵芝)

由福建野生紫芝人工驯化得到的栽培菌株“闽紫96”,子实体中型,菌盖大小7．0～9．0×10．0～17．3cm,其担孢子形态饱满,6．84～7．37×10．26～11．05μm,较灵芝担孢子大;标本(HMAS 77207)经鉴定确认为紫芝(Ganoderma siruense J．D．Zhao,L．W．Hsu et X．Q．Zhang),是符合《中华人民共和国药典》记载的灵芝药材的来源菌物。2004-2005年,采用阔叶树枝桠材栽培“闽紫96”,推广栽培面积860m~3(菌材),平均年产量为12．70 kg/m~3(干品/菌材)。将“闽紫96”子实体超微粉碎加工成300目超细粉。扫描电镜观察可见:其超细粉呈纤维状,以分散、破碎的茵丝片段形态存在,长度范围为10～50μm,直径1．2～4．5μm不等;激光粒度检测结果表明:超细粉的表面积达到227．54 m~2/kg,D97=63．8μm。化学成分分析结果表明:“闽紫96”超细粉的水分、粗蛋白、粗脂肪、粗纤维、总糖、灰分及多糖含量分别为4．2 g/100g、10．84g/100g、3．71 g/100g、36．5g/100g、30．2g/100g、1．7 g/100g和1．3 g/100g;所含17种氨基酸总量为9．30 mg/100mg,其中必需氨基酸占65．7%;其脂肪酸构成以油酸(45．5%)、亚油酸(27．7%)及棕榈酸(18．8%)为主。此外,其重金属元素Pb,As,Hg,Cd等含量分别为＜0．2 mg/g、0．13 mg/g、0．072 mg/g、0．24 mg/g,符合国家商务部《药用植物及制剂外经贸绿色行业标准》(WM/T2-2004)要求。     

HPLC测定驼鹿和狍雪尿肌酐及嘌呤衍生物

反刍动物尿液中嘌呤衍生物的含量可以间接反映其营养状态.高效液相色谱技术(HPLC)是测定反刍动物尿液中嘌呤衍生物含量的重要技术手段之一.本文通过优化的液相色谱条件(依利特-C18(200 mm×4.6mm,5μm)色谱柱;流动相:0.01 mol/L KH2PO4、20%乙腈 80%0.01 mol/L KH2PO4;流速1.0 ml/min;柱温20℃;检测波长220 nm,254 nm),测定出野生驼鹿和狍雪尿中肌酐及嘌呤衍生物的含量.测定结果显示,尿囊素、肌酐、尿酸、次黄嘌呤、黄嘌呤在0.0010～0.2000 mg/ml范围内线性关系良好(R2=0.9999),标准品回收率均在96%～105%范围内;2006和2007年冬季在黑龙江省胜山和沾河两个林场所采集的所有驼鹿以及近三分之一的狍雪尿样本中,未检测到尿囊素的存在,所有未检测到尿囊素的驼鹿和狍雪尿样本中,黄嘌呤和次黄嘌呤之和占嘌呤衍生物总量的20.7%～55.2%,而所有可检测到尿囊素的尿液样品中,黄嘌呤和次黄嘌呤之和占嘌呤衍生物总量的15.2%～36.1%,尿囊素占嘌呤衍生物总量的40.6%～85.6%,表明所有驼鹿和部分狍个体越冬时可能存在一定程度的营养限制,且驼鹿和狍的营养代谢存在着种间差异.因此,这种非损伤性的测定方法可以快速、有效地评估冬季鹿类动物营养状况,对其营养状况进行动态监测,揭示出不同物种之间营养动态的差异性,并为野生有蹄类种群和生境的有效保护管理提供科学依据.     

Crystal structure, detonation performance, and thermal stability of a new polynitro cage compound: 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptacyclo [5.5.1.13, 11. 15, 9] pentadecane

A new polynitro cage compound 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptcyclo [5.5.1.1(3,11).1(5,9)] pentadecane (NNNAHP) was designed in the present work. Its molecular structure was optimized at the B3LYP/6-31 G(d,p) level of density functional theory (DFT) and crystal structure was predicted using the Compass and Dreiding force fields and refined by DFT GGA-RPBE method. The obtained crystal structure of NNNAHP belongs to the P-1 space group and the lattice parameters are a = 9.99 ?, b = 10.78 ?, c = 9.99 ?, α = 90.01°, β = 120.01°, γ = 90.00°, and Z = 2, respectively. Based on the optimized crystal structure, the band gap, density of state, thermodynamic properties, infrared spectrum, strain energy, detonation characteristics, and thermal stability were predicted. Calculation results show that NNNAHP has detonation properties close to those of CL-20 and is a high energy density compound with moderate stability.     

Distribution of N,P, K,Ca, Mg,S, Zn,Fe, Mn and Cu in groundnut

Summary Concentration of N, P, K, Ca, Mg and S in summer groundnut crop was higher than in kharif while Zn, Fe, Mn and Cu contents were higher in summer crop. Kernel's N, P and Zn; Leaflet's Ca and Mn; Stem's K and Fe; Root's S and Cu and Petiole's Mg contents were highest. Shell's N, P, K, Mg, S, Zn and Cu; Kernel's Ca, Fe and Mn contents were the least. N, P, K, S, Zn and Cu concentrations decreased linearly as the crop grew. Ca, Mg, Fe and Mn concentrations did not display any distinct pattern. Ca concentration was positively correlated with pod yield in both the seasons.     

Relations of the Al,B, Ba,Br, Ca,Cl, Cu,Fe, K,Li, Mg,Mn, Na,P, S,Si, Sr,and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands

The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0–30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work’s results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0–30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.     

Simultaneous measurement of the trace elements Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum and their reference ranges by ICP-MS

The goal of this article was to establish reference ranges of the concentration of trace elements in human serum and to compare these results with those reported by other authors. We describe the sample preparation and measurement conditions that allow the rapid, precise, and accurate determination of Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum samples (n=110) by inductively coupled plasma-mass spectrometry (ICP-MS). Accuracy and precision were determined by analyzing three reconstituted reference serum samples by comparison with other methods and by the standard addition procedure. The advantages of the ICP-MS method include short time of analysis of the elements mentioned, low detection limit, high precision, and high accuracy. Disadventages include a high risk of contamination due to the presence of some of the elements of interest in the environment, the relatively delicate sample handling, and the high cost of the equipment.     

Reference values for the concentrations of As,Cd, Co,Cr, Cu,Fe, I,Hg, Mn,Mo, Ni,Pb, Se,and Zn in selected human tissues and body fluids

This report attempts to formulate reference ranges of elemental concentrations for 15 trace elements in selected human tissues and body fluids. A set of samples consisting of whole blood, blood serum, urine, milk, liver, and hair were chosen and considered for 15 elements of biological significance: As, Cd, Co, Cr, Cu, F, Fe, I, Hg, Mn, Mo, Ni, Pb, Se, and Zn. The results represent wholly or partially data received from 40 countries of the global regions of Africa, Asia, Europe, North, South, and Central America, Australia, and New Zealand. This survey, even if qualitative, has been useful in demonstrating certain trends of trace-element scenarios around the world. It is of course recognized that both diet and environment exert a strong influence on the distribution pattern of several elements, such as As, Cd, Mn, Pb, Se, and Zn. A limited comparison of the available information on soil status of different countries reflected some interesting associations for elements, such as Mn and Zn. Importantly, this study revealed that only a few countries were in a position to identify a reasonable amount of data on samples requested for this project. Regretably, for a number of countries, any dependable data for even such essential elements as Cu, Fe, and Zn were not available. In view of the nutritional importance of many elements, the time is ripe for concerted efforts by intergovernmental agencies to initiate investigations or commission task forces/projects to generate reliable reference data for selected global regions, which sadly lack data of any kind at present.     

The Effect of Age and Gender on Al, B, Ba, Ca, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Sr, V, and Zn Contents in Rib Bone of Healthy Humans

The effect of age and gender on major, minor, and trace element contents in the intact rib bone of 80 relatively healthy 15–55-year-old women and men was investigated. Contents or upper limit of contents of 16 chemical elements in the rib bone were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). Mean values (M?±?SΕΜ) for the mass fraction of Ba, Ca, Cu, Fe, K, Li, Mg, Na, P, S, Sr, and Zn (milligram per kilogram of dry bone) were as follows: 2.54?±?0.16, 171,400?±?4,050, 1.35?±?0.22, 140?±?11, 1,874?±?71, 0.049?±?0.011, 2,139?±?38, 5,378?±?88, 75,140?±?1,660, 1,881?±?51, 291?±?20, and 92.8?±?1.5, respectively. The upper limits of contents of Al, B, Mn, and V were <7.20, <0.65, <0.36, and <0.03, respectively. Statistically significant tendency for the Ca, Mg, and P content to decrease with age was found in the human rib bone, regardless of gender. The mass fraction of Fe in the male rib bone increases with age. It was shown that higher Ca, Mg, Na, P, and Sr mass fractions as well as lower Fe content were typical of female ribs as compared to those in male ribs.     

Potential Compounds for Oral Cancer Treatment: Resveratrol,Nimbolide, Lovastatin,Bortezomib, Vorinostat,Berberine, Pterostilbene,Deguelin, Andrographolide,and Colchicine

Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer. Research endeavors focused on discovery and development of novel therapies for oral cancer, is necessary to control the ever rising oral cancer related mortalities. We mined the large pool of compounds from the publicly available compound databases, to identify potential therapeutic compounds for oral cancer. Over 84 million compounds were screened for the possible anti-cancer activity by custom build SVM classifier. The molecular targets of the predicted anti-cancer compounds were mined from reliable sources like experimental bioassays studies associated with the compound, and from protein-compound interaction databases. Therapeutic compounds from DrugBank, and a list of natural anti-cancer compounds derived from literature mining of published studies, were used for building partial least squares regression model. The regression model thus built, was used for the estimation of oral cancer specific weights based on the molecular targets. These weights were used to compute scores for screening the predicted anti-cancer compounds for their potential to treat oral cancer. The list of potential compounds was annotated with corresponding physicochemical properties, cancer specific bioactivity evidences, and literature evidences. In all, 288 compounds with the potential to treat oral cancer were identified in the current study. The majority of the compounds in this list are natural products, which are well-tolerated and have minimal side-effects compared to the synthetic counterparts. Some of the potential therapeutic compounds identified in the current study are resveratrol, nimbolide, lovastatin, bortezomib, vorinostat, berberine, pterostilbene, deguelin, andrographolide, and colchicine.