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1.
Slavutskaia MV Shul'govskiĭ VV 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2003,53(3):341-350
The EEG of 10 right-handed subjects preceding saccades with mean values of latent periods were selected and averaged. Two standard paradigms of presentation of visual stimuli (central fixation stimulus-peripheral target succession): with a 200-ms inerstimulus interval (GAP) and successive single step (SS). During the period of central fixation, two kinds of positive potentials were observed: fast potentials of "inermediate" positivity (IP) developing 600-400 ms prior to saccade onset and fast potentials of "leading" positivity (LP), which immediately preceded the offset of the central fixation stimulus. Peak latency of the LP potentials was 300 ms prior to saccade onset in the SS paradigm and 400 ms in the GAP paradigm. These potentials were predominantly recorded in the frontal and frontosagittal cortical areas. Decrease in the latency by 30-50 ms in the GAP paradigm was associated with more pronounced positive potentials during the fixation period and absence of the initiation potential P-1' (or decrease in its amplitude). The obtained evidence suggest that the fast positive presaccadic potentials are of a complex nature related to attention, anticipation, motor preparation, decision making, saccadic initiation, and backward afferentation. 相似文献
2.
Aleksandrov AA Poliakova NV Stankevich LN 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2003,89(7):769-775
The effect of stimulus duration on auditory event-related potentials and performance of oddball task was studied in normal children and those with attention-deficit symptoms. Mismatch negativity was absent on presentation of short-term (11 ms) stimuli and present with longer stimuli (50 ms). The adolescents with deficit of attention performed much worse (errors of omission) with the short stimuli. The RT was significantly larger in subjects with attention-deficit with all types of tested stimulus duration. They also manifested a smaller P3b amplitude in response to task-relevant deviant stimuli and larger N2b peaks in response to the standard stimuli. It was possible to differentiate between the MMN and the N2b components owing to the fact that the MMN was absent with shorter stimuli. The findings suggest that there is a deficit in processing of sensory information at the cortical level in subjects with the attention-deficit symptoms. 相似文献
3.
S Makeig M Westerfield J Townsend T P Jung E Courchesne T J Sejnowski 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1999,354(1387):1135-1144
Spatial visual attention modulates the first negative-going deflection in the human averaged event-related potential (ERP) in response to visual target and non-target stimuli (the N1 complex). Here we demonstrate a decomposition of N1 into functionally independent subcomponents with functionally distinct relations to task and stimulus conditions. ERPs were collected from 20 subjects in response to visual target and non-target stimuli presented at five attended and non-attended screen locations. Independent component analysis, a new method for blind source separation, was trained simultaneously on 500 ms grand average responses from all 25 stimulus-attention conditions and decomposed the non-target N1 complexes into five spatially fixed, temporally independent and physiologically plausible components. Activity of an early, laterally symmetrical component pair (N1aR and N1aL) was evoked by the left and right visual field stimuli, respectively. Component N1aR peaked ca. 9 ms earlier than N1aL. Central stimuli evoked both components with the same peak latency difference, producing a bilateral scalp distribution. The amplitudes of these components were no reliably augmented by spatial attention. Stimuli in the right visual field evoked activity in a spatio-temporally overlapping bilateral component (N1b) that peaked at ca. 180 ms and was strongly enhanced by attention. Stimuli presented at unattended locations evoked a fourth component (P2a) peaking near 240 ms. A fifth component (P3f) was evoked only by targets presented in either visual field. The distinct response patterns of these components across the array of stimulus and attention conditions suggest that they reflect activity in functionally independent brain systems involved in processing attended and unattended visuospatial events. 相似文献
4.
In a complex choice reaction time experiment, patterned stimuli without luminance change were presented, and pattern-specific visual evoked potentials to lower half-field stimulation were recorded. Two experimental conditions were used. The first was the between-field selection, where square patterns were presented in either the lower or the upper half of the visual field. In a given stimulus run one of the half-fields was task-relevant, and the subjects' task was to press a microswitch to stimuli of higher duration value (GO stimuli), while they had to ignore shorter ones, i. e. stimuli of lower apparent spatial contrast (NOGO stimuli). They had to ignore the stimuli appearing in the irrelevant half-field (IRR stimuli). In order to ensure proper fixation, the subjects had to press another microswitch at the onset of a dim light at the fixation point (CRT stimuli). Our second experimental condition was the within-field selection, where the GO, NOGO, and IRR stimuli appeared in the lower half of the visual field. GO and NOGO were square patterns while IRR stimuli were constructed of circles, or vice versa. (The CRT stimuli were the same as in the previous condition.) Three pattern-specific visual evoked potential components were identified, i. e. CI (70 ms latency), CII (100 ms latency), and CIII (170 ms latency). There were marked selective attention effects on both the CI-CII and CII-CIII peak-to-peak amplitudes. In both experimental conditions, responses with the highest amplitude were evoked by the GO type of stimuli, while the IRR stimuli evoked the smallest responses. According to these results, attention effects on the pattern-specific visual evoked potentials in the first 200 ms cannot be attributed to a simple stimulus set kind of selection. 相似文献
5.
The purpose of the experiment was to study the effects of psychological factors on slow brain potentials in relation to information processing and strategy establishment. Subjects were subjected to paired stimuli: A) two identical tone bursts (50 ms, 5000 Hz); B) two different stimuli the second (unconditioned) was a low pitched tone burst (50 ms, 500 Hz); C) only the warning stimulus was delivered to the subjects. In a first experiment, subjects (N = 10) were asked to detect and signal by a motor act the low pitched click (B); in a second experiment, subjects (N = 8) were to detect and signal in the same way the unconditioned tone burst omission (C). Results showed that the auditory event-related potentials (ERP) obtained in the two experiments presented two components: a negative wave (N150) followed by a positive one (P270). Solely, the late positive component differed in topography during the two situations. A fronto-central Contingent Negative Variation (CNV) appeared in all the conditions for the two experiments while a Post Imperative Negative Variation was often obvious in the first experiment. 相似文献
6.
在用事件相关电位(event-related potentials,ERP)研究视觉空间注意问题时,直接观察ERP数据就可得出,空间注意的主要作用是对视觉信息处理的调制,它出现在刺激开始后大约80~250ms,主要表现为枕叶的P1、N1和P2波有明显的增强但它们的潜伏期没有变化。采用基于协同学的时空模式分解方法,把视觉空间注意ERP分解为3个模式成分。结果表明,注意不仅使模式1的第一个正波成分(P11)、第一个负波成分(N11)以及第二个正波成分(P12)增强,还使模式3的第一个正波成分(P31)的潜伏期缩短。用探照灯模型对这些现象作了初步解释,说明该方法是研究注意ERP的一种有潜力的新方法。 相似文献
7.
Research on the effects of self-regulation of slow potentials (SP) and event-related potentials (ERP) has failed to look at the possible interactions of these two kinds of brain potentials. The present study investigated such interactions by recording both ERP and SP potential changes in an operant ERP conditioning paradigm. Ten subjects participated in two conditions that were designed to differentially manipulate attention to the stimuli. In the operant conditioning task, subjects received auditory feedback as they attempted to increase the ERP amplitude at 180 msec poststimulus (P180), which was elicited by a subpainful shock stimulus to the forearm over 250 trials. In the distraction task, subjects were instructed not to attend to stimuli or feedback tones, but rather received and were tested on reading materials. Attention, as manipulated by these tasks, was not a determinant of changes in ERP amplitude since there were no significant differences in the size of P180 between attention conditions. While no significant change in the mean ERP amplitude occurred, subjects were able to produce ERPs above criterion threshold significantly more often during trials in the conditioning task than in the reading task. Thus, there was evidence of some learning. The difference in wave forms between hit and miss trials indicates a latency shift (with misses having a later ERP peak). This may indicate that latency, rather than, or in addition to, amplitude, is shaped during conditioning procedures. In addition, the CNV that developed between the shock stimulus and the feedback signal during conditioning was significantly larger in amplitude than in the distraction condition. This is taken as evidence of increased attention during conditioning. Since hit trials demonstrated larger contingent negative variation (CNV) amplitudes, production of CNVs may be instrumental in mediating hits. Therefore, attentional mechanisms may play a role in successful ERP self-regulation. No correlations were found involving P180, CNVs, or tonic slow potential shifts. Changes in tonic DC levels showed a suggestive trend between conditions. Although both conditions began with a negative shift, during conditioning the negativity increased, while during distraction the tonic level went to positivity. These trends support the hypothesis that attention and arousal increased during conditioning. The possible reasons for the lack of significant correlations between ERP and tonic or phasic slow potential changes in this paradigm are discussed. 相似文献
8.
Slavutskaia MV Shul'govskiĭ VV Semina TK 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2005,55(6):788-797
Saccadic latency and averaged EEG-potentials connected with switching on of the set and cue visual stimuli were examined in 12 right-handed healthy subjects in M. Posner's "cost-benefit" experimental paradigm. It was shown that attention was reflected in parameters of positive potential P100 evoked by switching on of set and cue stimuli and P300 and slow positive wave PMP1 evoked by switching on of the set stimulus in the relevant conditions. The spatiotemporal pattern of P100 probably reflects the involvement of the frontoparietal network of spacial attention in the perception of a relevant stimulus. Prevalence of the P300 and PMP1 potentials in the right parietal cortex suggests that these potentials reflect processes of space attention and visual fixation. Late positive potentials in a 600-900-ms interval after switching on of the set stimulus were found. Their amplitude was higher in backward averaging and they were predominantly localized in the left frontal cortex. These findings suggest that the late potentials reflect the anticipation and motor attention processes. 相似文献
9.
Carla Douros Rathe Karrer J. Peter Rosenfeld 《Applied psychophysiology and biofeedback》1987,12(1):39-49
Research on the effects of self-regulation of slow potentials (SP) and event-related potentials (ERP) has failed to look at the possible interactions of these two kinds of brain potentials. The present study investigated such interactions by recording both ERP and SP potential changes in an operant ERP conditioning paradigm. Ten subjects participated in two conditions that were designed to differentially manipulate attention to the stimuli. In the operant conditioning task, subjects received auditory feedback as they attempted to increase the ERP amplitude at 180 msec poststimulus (P180), which was elicited by a subpainful shock stimulus to the forearm over 250 trials. In the distraction task, subjects were instructed not to attend to stimuli or feedback tones, but rather received and were tested on reading materials. Attention, as manipulated by these tasks, was not a determinant of changes in ERP amplitude since there were no significant differences in the size of P180 between attention conditions. While no significant change in the mean ERP amplitude occurred, subjects were able to produce ERPs above criterion threshold significantly more often during trials in the conditioning task than in the reading task. Thus, there was evidence of some learning. The difference in wave forms between hit and miss trials indicates a latency shift (with misses having a later ERP peak). This may indicate that latency, rather than, or in addition to, amplitude, is shaped during conditioning procedures. In addition, the CNV that developed between the shock stimulus and the feedback signal during conditioning was significantly larger in amplitude than in the distraction condition. This is taken as evidence of increased attention during conditioning. Since hit trials demonstrated larger contingent negative variation (CNV) amplitudes, production of CNVs may be instrumental in mediating hits. Therefore, attentional mechanisms may play a role in successful ERP self-regulation. No correlations were found involving P180, CNVs, or tonic slow potential shifts. Changes in tonic DC levels showed a suggestive trend between conditions. Although both conditions began with a negative shift, during conditioning the negativity increased, while during distraction the tonic level went to positivity. These trends support the hypothesis that attention and arousal increased during conditioning. The possible reasons for the lack of significant correlations between ERP and tonic or phasic slow potential changes in this paradigm are discussedThis research was partially supported by NICHD Grant HD 15327 to R. Karrer, NIH Grant DE05204 to J. P. Rosenfeld, and the Office of Social Science Research at University of Illinois at Chicago. Appreciation is extended to G. Dombrowski for his assistance in data analysis. 相似文献
10.
Neuronal pathways for the lingual reflex in the Japanese toad 总被引:1,自引:0,他引:1
Toshiya Matsushima Masahiko Satou Kazuo Ueda 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1988,164(2):173-193
1. Anuran tongue is controlled by visual stimuli for releasing the prey-catching behavior ('snapping') and also by the intra-oral stimuli for eliciting the lingual reflex. To elucidate the neural mechanisms controlling tongue movements, we analyzed the neuronal pathways from the glossopharyngeal (IX) afferents to the hypoglossal (XII) tongue-muscle motoneurons. 2. Field potentials were recorded from the bulbar dorsal surface over the fasciculus solitarius (fsol) to the electrical stimulation of the ipsilateral IX nerve. They were composed of three successive negative waves: S1, S2 and N wave. The S1 and S2 waves followed successive stimuli applied at short intervals (10 ms or less), whereas the N wave was strongly suppressed at intervals shorter than 500 ms. Furthermore, the S1 wave had lower threshold than the S2 wave. 3. Orthodromic action potentials were intra-axonally recorded from IX afferent fibers in the fsol to the ipsilateral IX nerve stimuli. Two peaks found in the latency distribution histogram of these action potentials well coincided with the negative peaks of the S1 and the S2 waves of the simultaneously recorded field potentials. Therefore, the S1 and S2 waves should represent the compound action potentials of two groups of the IX afferent fibers with different conduction velocities. 4. Ipsilateral IX nerve stimuli elicited excitatory postsynaptic potentials (EPSPs) in the tongue-protractor motoneurons (PMNs) and the tongue-retractor motoneurons (RMNs). Inhibitory postsynaptic potentials were not observed. 5. The EPSPs recorded in PMNs had mean onset latencies of 6.4 ms measured from the negative peaks of the S1 wave. The EPSPs were facilitated when paired submaximal stimuli were applied at intervals shorter than 20 ms, but were suppressed at intervals longer than 30 ms. Furthermore, the EPSPs were spatially facilitated when peripherally split two bundles of the IX nerve were simultaneously stimulated. 6. On the other hand, the EPSPs recorded in RMNs had shorter onset latencies, averaging 2.5 ms. In 14 of 43 RMNs, early and late EPSP components could be reliably discriminated. The thresholds for the early EPSP components were as low as those for the S1 waves, whereas for the late EPSP components the thresholds were usually higher than those for the S2 waves.(ABSTRACT TRUNCATED AT 400 WORDS) 相似文献
11.
Fast presaccadic EEG potentials in saccadic latency were studied with the use of inverse averaging during monocular stimulation of the leading or nonleading eye. Two paradigms were followed, with presentation of visual stimuli consecutively or with a 200-ms overlap. Irrespective of the paradigm and the stimulated eye, the negative N
–1 potential in the interval of 50–20 ms preceding the beginning of the saccade predominated in the hemisphere contralateral to the saccade direction, reflecting the command processes of saccadic initiation. The N
–2 potential was more pronounced in the case of direct averaging, starting from the stimulus. Its amplitude increased with increasing concentration of attention on the fixation stimulus under the overlap conditions, and its foci predominated in the left hemisphere, in the frontal, central, and parietosagittal regions. Hence, the N
–2 potential was assumed to reflect spatial perception and attention as initial stages of saccadic programming. The findings testify to the priority of the leading eye both in fixation and in spatial attention. 相似文献
12.
Petrek J 《Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia》2004,148(2):145-152
Event-related potentials (ERPs) to word stimuli were registered in 20 twenty-one-year-old students (7 males and 13 females) of the Faculty of Medicine of Palacky University. In an ideal case in the first 800 ms after the onset of stimulus ERP consists of three clear positive and four negative waves. The amplitude of some waves of ERPs shows a high degree of inter-individual variability. It was also revealed that the latency and amplitude of some ERPs waves to word stimuli depends on the gender and on the site of the registration electrode on the scalp of the subject. Latencies of components LP2 and LN4 in all electrodes are shorter in females than in males, component LN2 behaves reversely--its latency is shorter in males. On the other hand, the amplitude of dependent variables BP2, BN2 and PV1 is in most electrodes higher in females than in males--except for the amplitude of components BP4 and BN1. 相似文献
13.
《Electronic Notes in Theoretical Computer Science》1997,104(1):23-30
The auditory P50 in humans may consist of overlapping potentials. To test this hypothesis, we manipulated the conditions of stimulus discrimination and motor response difficulty and evaluated the data by factor analysis. Twenty right-handed males (mean age 27 years) performed the following 4 tasks: (1) a counting task, (2) an easy Go, No-Go task, (3) a difficult Go, No-Go task, and (4) a choice reaction task. Middle latency auditory evoked potentials were obtained with 100 times summation triggered by the onset of the auditory stimulus. Four factors were extracted by factor analysis for a 0–100 ms time period. Factor 1, the maximum factor loading at 91 ms, corresponded to N1, and factor 4, the maximum factor loading at 23 ms, appeared to correspond to P30. The latency of the maximum factor loading in factor 2 was adjacent to that in factor 3, the latency of factor 2 being 12 ms earlier than that of factor 3. Factor 2 and factor 3 latencies were approximately 55 ms which corresponded to the P50. Factor 3 started rising at the point that factor 2 reached the maximum factor loading, and the factor score demonstrated a significant group difference only when analyzed by motor response criteria. These results suggest that the P50 in humans consists of overlapping potentials and that a part of the potential might relate to a motor response process. 相似文献
14.
The authors recorded cerebral-evoked responses elicited by direct stimulation of the human lateral spinothalamic tract (LST) during percutaneous cordotomy to investigate central conduction of noxious stimuli. These responses consisted of four negative potentials, peak latency being 3.8 (N1), 8.4 (N2), 12.2 (N3) and 21.9 (N4) ms respectively. N1 showed wide distribution over the scalp and was considered to be of subcortical origin. N2-N4 were distributed in both the temporal and central area. The different distribution pattern of N2-N4 from conventional somatosensory-evoked potential suggested a different projection of LST from the medial lemniscus system. 相似文献
15.
16.
Slavutskaia MV Shul'govskiĭ VV 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2002,52(5):551-562
In 10 right-handed healthy subjects EEGs preceding saccades with mean latent periods were selectively averaged. Two standard schemes of visual stimulation were used: with immediate presentation of a peripheral target stimuli after the central fixation stimulus (a single step paradigm) and with the interval between the stimuli in 200 ms (GAP paradigm). Two waves of slow premotor negativity (early PMN1 and late PMN2) that appeared 930 +/- 79 and 609 +/- 82 ms, respectively, prior to a saccade onset were observed. The PMN2 was followed by the negative potentials N-3, N-2, and N-1 (saccadic initiation potential). It was found that in GAP stimulation condition the PMN1 was less pronounces and N-1 was increased as compared to the single step. These findings suggest that disengage of attention from the central point during the GAP period clears the saccadic system for decision making and initiation of a saccade. Under such conditions, the expectation of a visual target does not require a high level of nonspecific activation and motor attention. 相似文献
17.
《Electronic Notes in Theoretical Computer Science》1996,100(1):18-24
Visual event-related potentials (ERPs) were recorded during a simple response task (SRT) and a discriminative response task (DRT) in remitted schizophrenic outpatients and age-matched controls to examine 2 endogenous negative potentials: NA and N2c. The NA potentials were derived by subtracting the ERPs for SRT from those for non-target stimuli in DRT. Other subtracting wave forms, N2c potentials, were calculated as the difference between ERPs for target and non-target stimuli in DRT. Schizophrenics showed retardation in NA and N2c peaks and degradation in N2c amplitude relative to controls. The NA peak latency increased as much as the latencies of N2c and reaction time for DRT in schizophrenia. The NA peak emerged prior to the N2c peak, while the NA peak latency correlated closely with the N2c latency. These results indicate that the retarded NA peak latency may serve as a physiological marker for neurobiological vulnerability of schizophrenia. 相似文献
18.
Healthy subjects (n = 88) were asked to passively visualize positive and passive emotiogenic visual stimuli and also stimuli with a neutral emotional
content. Images of the International Affective Picture System (IAPS) were used. Amplitude/time characteristics of the components
of evoked EEG potentials (EPs), P1, N1, P2, N2, and P3 and topographic distribution of the latter components were analyzed.
The latencies, amplitudes, and topography of the EP waves induced by presentation of positive and negative stimuli were found
to be different from the respective values for the EPs induced by neutral stimuli. The level and pattern of these differences
typical of different EP components were dissimilar and depended on the sign of the emotions. Specificities related to the
valency of an identified stimulus were observed within nearly all stages of processing of visual signals, for the negative
stimuli, beginning from an early stage of sensory analysis corresponding to the development of wave Р1. The latencies of components
Р1 in the case of presentation of emotiogenic negative stimuli and those of components N1, N2, and Р3 in the case of presentation
of the stimuli of both valencies were shorter than the latencies observed at neutral stimuli. The amplitude of component N2
at perception of positive stimuli was, on average, lower, while the Р3 amplitude at perception of all emotiogenic stimuli
was higher than in the case of presentation of neutral stimuli. The time dynamics of topographic peculiarities of processing
of emotiogenic information were complicated. Activation of the left hemisphere was observed during the earliest stages of
perception, while the right hemisphere was activated within the intermediate stages. Generalized activation of the cortex
after the action of negative signals and dominance of the left hemisphere under conditions of presentation of positive stimuli
were observed only within the final stages. As is supposed, emotiogenic stimuli possess a greater biological significance
than neutral ones, and this is why the former attract visual attention first; they more intensely activate the respective
cortical zones, and the corresponding visual information is processed more rapidly. The observed effects were more clearly
expressed in the case of action of negative stimuli; these effects involved more extensive cortical zones. These facts are
indicative of the higher intensity of activating influences of negative emotiogenic stimuli on neutral systems of the higher
CNS structures. 相似文献
19.
《Electronic Notes in Theoretical Computer Science》1996,100(2):105-114
We recorded cortical potentials evoked by painful CO2 laser stimulation (pain SEP), employing an oddball paradigm in an effort to demonstrate event-related potentials (ERP) associated with pain. In 12 healthy subjects, frequent (standard) pain stimuli (probability 0.8) were delivered to one side of the dorsum of the left hand while rare (target) pain stimuli (probability 0.2) were delivered to the other side of the same hand. Subjects were instructed to perform either a mental count or button press in response to the target stimuli. Two early components (N2 and P2) of the pain SEP demonstrated a Cz maximal distribution, and showed no difference in latency, amplitude or scalp topography between the oddball conditions or between response tasks. In addition, another positive component (P3) following the P2 was recorded maximally at Pz only in response to the target stimuli with a peak latency of 593 msec for the count task and 560 msec for the button press task. Its scalp topography was the same as that for electric and auditory P3. The longer latency of pain P3 can be explained not only by its slower impulse conduction but also by the effects of task difficulty in the oddball paradigm employing the pain stimulus compared with electric and auditory stimulus paradigms. It is concluded that the P3 for the pain modality is mainly related to a cognitive process and corresponds to the P3 of electric and auditory evoked responses, whereas both N2 and P2 are mainly pain-related components. 相似文献
20.
V. V. Garkavenko I. N. Karaban’ M. T. Kapustina L. I. Limanskaya 《Neurophysiology》1999,31(6):399-402
In 18 27- to 56-year-old tested subjects, we measured the latency of sensorimotor reactions (SMRL) and parameters of the somatosensory
evoked potentials (SSEP), related to these reactions, observed in two experimental paradigms. In test 1, every third stimulus
in a train of identical stimuli was considered the “necessary” signal, while in test 2, the subject had to select such a signal
from three different versions of the stimuli presented in a randomized manner. For each subject, we selectively averaged the
SSEP related to different (short and long) SMRL. We demonstrated the existence of different types of the dependences between
the SSEP parameters and the values of SMRL; the pattern of these dependences could be different in tests 1 and 2. For test
1, a negative dependence between the variations of SMRL and amplitude of the P100 SSEP component was observed, while test
2 results were characterized by a clearly expressed negative correlation between the SMRL, and N150 amplitude (P<0.05). Negative correlation between the SMRL and integral amplitude of the P100-N150-P250 complex (P<0.05) was a common manifestation of the dependence between the SMR and SSEP parameters observed under conditions of both
tests. We suppose that the dependences between the variations of SSEP parameters and SMRL values reflect changes in the level
of mobilization of attention and in the structure of the latter in the course of performance of a sensorimotor task. 相似文献