Principles of E-Cadherin Supramolecular Organization In Vivo

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Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo

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Designed Hsp90 Heterodimers Reveal an Asymmetric ATPase-Driven Mechanism In Vivo

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Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1

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An EB1-Kinesin Complex Is Sufficient to Steer Microtubule Growth In Vitro

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A Drosophila In Vivo Screen Identifies Store-Operated Calcium Entry as a Key Regulator of Adiposity

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High-Mobility Group Box 1 Is Dispensable for Autophagy,Mitochondrial Quality Control,and Organ Function In Vivo

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Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

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Hebbian Plasticity Guides Maturation of Glutamate Receptor Fields In Vivo

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Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

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Highlights? GA is metabolized by CYP2E1 to produce a metabolite proteasome inhibitor ? Proteasome inhibition is required for GA’s cytotoxicity and anticancer activity ? GA is a more tissue-specific proteasome inhibitor than bortezomib/velcade ? GA is nontoxic to peripheral white blood cells compared to bortezomib     

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

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Bivalent Chromatin Marks Developmental Regulatory Genes in the Mouse Embryonic Germline In Vivo

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Estimating the Microtubule GTP Cap Size In Vivo

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Highlights? The microtubule (MT) GTP cap is ～750 tubulin subunits in vivo and extends over 1 μm ? EGFP brightness can be calibrated in vivo using GFP-tubulin signals from MTs ? The presence of GTP-tubulin in the MT lattice influences MT shortening and rescue ? MT tip trackers, like EB1, can be highly concentrated at the MT plus end (～100 μM)     

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

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Highlights? Loss of AMPKα1 cooperates with the Myc oncogene to accelerate lymphomagenesis ? AMPKα dysfunction enhances aerobic glycolysis (Warburg effect) ? Inhibiting HIF-1α reverses the metabolic effects of AMPKα loss ? HIF-1α mediates the growth advantage of tumors with reduced AMPK signaling     

Integration of Genome-wide Approaches Identifies lncRNAs of Adult Neural Stem Cells and Their Progeny In Vivo

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Highlights? RNA-seq, RNA Capture-Seq of SVZ-NSCs reveals unannotated lncRNAs and splice variants ? lncRNA loci have dynamic chromatin signatures, including bivalency in SVZ-NSCs ? Online resource facilitates discovery of lncRNAs involved in adult neurogenesis ? lncRNAs can regulate glial-neuronal lineage specification of SVZ-NSCs     

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

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Highlights? HIF is necessary and sufficient to induce reductive carboxylation in RCC cell lines ? HIF promotes the reductive carboxylation flux by reducing citrate levels ? HIF-expressing tumors display reductive carboxylation in vivo ? HIF renders RCC cells sensitive to glutaminase inhibition in vitro and in vivo     

In Vivo Epigenomic Profiling of Germ Cells Reveals Germ Cell Molecular Signatures

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Highlights? Modified small-scale ChIP-seq method applicable to small number of cells ? Genome-wide maps of H3K4me3, H3K27me3, H3K27ac, and H2BK20ac of germ cells in vivo ? Identification of active and inactive regulatory elements in germ cells in vivo ? Germ cell H3K27me3 regions are enriched for retrotransposon repeats     

In Vivo SILAC-Based Proteomics Reveals Phosphoproteome Changes during Mouse Skin Carcinogenesis

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Highlights? In vivo SILAC-based quantitative phosphoproteomics of skin carcinogenesis ? Phosphoproteomics identifies distinct signatures in skin and tumor tissues ? Phosphoproteomics pinpoints differences between papilloma and SCC tissues ? Predicted PAK4-PKC/SRC network is highly deregulated in SCC, but not papilloma     

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

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Origin of Lactose Fermentation in Kluyveromyces lactis by Interspecies Transfer of a Neo-functionalized Gene Cluster during Domestication

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