Avoiding Coral Reef Functional Collapse Requires Local and Global Action

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Mechanisms Preserving Insulin Action during High Dietary Fat Intake

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An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

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Autoregulation of RCO by Low-Affinity Binding Modulates Cytokinin Action and Shapes Leaf Diversity

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Action Selection and Flexible Switching Controlled by the Intralaminar Thalamic Neurons

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Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1

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Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging

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The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action

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Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

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Highlights

• •Anticancer activity of midostaurin but not other PKC inhibitors in NSCLC cells.
• •Mechanism of action by network-based integration of chemo- and phosphoproteomics.
• •Midostaurin polypharmacology by simultaneous inhibition of TBK1, PDPK1 and AURKA.
• •Design of synergistic drug combination with PLK1 inhibitor by pathway validation.

     

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

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Polyphosphate Is a Primordial Chaperone

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Building a secreting nanomachine: a structural overview of the T3SS

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Engineering a local microenvironment for pancreatic islet replacement

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Metabolism and epigenetics: a link cancer cells exploit

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Identification of Phe187 as a Crucial Dimerization Determinant Facilitates Crystallization of a Monomeric Retroviral Integrase Core Domain

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A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

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Strong Reinforcing Selection in a Texas Wildflower

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Probiotics tailored to the infant: a window of opportunity

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Biomass pretreatments capable of enabling lignin valorization in a biorefinery process

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Energetic Pathway Sampling in a Protein Interaction Domain

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