To write better,write better paragraphs

A case of musicogenic epilepsy is reported in which the seizures were precipitated by singing voices. It was found that some singers'' voices were particularly epileptogenic and that some of their songs, but not others, would precipitate a seizure. A study of the "offending" songs and singers did not reveal a common key, chord, harmonic interval, pitch or rhythm, and the emotional feeling or intensity of the music did not seem to be relevant. However, the voices that caused the seizures had a throaty, "metallic" quality. Such a singing voice results from incorrect positioning of the larynx such that it is not allowed to descend fully during singing; consequently, the vowel sounds produced must be manipulated by the lips or jaw to be distinguished. This trait is most common in singers with a low voice range who sing softly and use a microphone. It is not seen in trained operatic or musical theatre singers. The results of repeated testing showed that the seizures in this patient were caused by listening to singers who positioned the larynx incorrectly.     

How to write consistently boring scientific literature

Although scientists typically insist that their research is very exciting and adventurous when they talk to laymen and prospective students, the allure of this enthusiasm is too often lost in the predictable, stilted structure and language of their scientific publications. I present here, a top-10 list of recommendations for how to write consistently boring scientific publications. I then discuss why we should and how we could make these contributions more accessible and exciting.     

Picoliter-scale protein microarrays by laser direct write

We demonstrate the accurate picoliter-scale dispensing of active proteins using a novel laser transfer technique. Droplets of protein solution are dispensed onto functionalized glass slides and into plastic microwells, activating as small as 50-microm diameter areas on these surfaces. Protein microarrays fabricated by laser transfer were assayed using standard fluorescent labeling techniques to demonstrate successful protein and antigen binding. These results indicate that laser transfer does not damage the active site of the dispensed protein and that this technique can be used to successfully fabricate a functioning protein microarray. Also, as a result of the efficient nature of the process, material usage is reduced by two to four orders of magnitude compared to conventional pin dispensing methods for protein spotting.     

Operational cost-aware resource provisioning for continuous write applications in cloud-of-clouds

The emergence of cloud computing has made it become an attractive solution for large-scale data processing and storage applications. Cloud infrastructures provide users a remote access to powerful computing capacity, large storage space and high network bandwidth to deploy various applications. With the support of cloud computing, many large-scale applications have been migrated to cloud infrastructures instead of running on in-house local servers. Among these applications, continuous write applications (CWAs) such as online surveillance systems, can significantly benefit due to the flexibility and advantages of cloud computing. However, with specific characteristics such as continuous data writing and processing, and high level demand of data availability, cloud service providers prefer to use sophisticated models for provisioning resources to meet CWAs’ demands while minimizing the operational cost of the infrastructure. In this paper, we present a novel architecture of multiple cloud service providers (CSPs) or commonly referred to as Cloud-of-Clouds. Based on this architecture, we propose two operational cost-aware algorithms for provisioning cloud resources for CWAs, namely neighboring optimal resource provisioning algorithm and global optimal resource provisioning algorithm, in order to minimize the operational cost and thereby maximizing the revenue of CSPs. We validate the proposed algorithms through comprehensive simulations. The two proposed algorithms are compared against each other to assess their effectiveness, and with a commonly used and practically viable round-robin approach. The results demonstrate that NORPA and GORPA outperform the conventional round-robin algorithm by reducing the operational cost by up to 28 and 57 %, respectively. The low complexity of the proposed cost-aware algorithms allows us to apply it to a realistic Cloud-of-Clouds environment in industry as well as academia.     

Using explicit teaching to improve how bioscience students write to the lay public

The media role model was recently developed to frame how science faculty members can teach their students to write more effectively to lay audiences (14). An Opinion Editorial (Op-Ed) was introduced as a novel assignment for final-year physiology and pharmacology undergraduates. This second phase of this study, reported here, demonstrated the efficacy of explicit teaching of the Op-Ed, using a one-shot, pre-/posttest research design. Baseline writing skills of students were determined from a communication assignment. Students were then explicitly taught how to write an Op-Ed and subsequently wrote an Op-Ed based on a recent, relevant scientific article. Most students achieved higher grades for their Op-Ed following explicit teaching [mean (SD) = 84.4% (9.1%), n = 216] compared with their communication assignment [mean (SD) = 74.7% (11.9%), n = 218]. Improvement in student writing was also evident by an increase in text readability, which mirrored the features of Op-Eds written by professional journalists. A survey of students (n = 142) indicated that most believed that the assignments were valuable and that their ability to write to a lay audience had improved. Members of the lay public were then surveyed for their opinions on student writing. Two assignments were selected from one student whose grades had improved after explicit teaching. Respondents (n = 78) indicated that the Op-Ed was easier to read than the communication assignment. Thus, explicit teaching of the Op-Ed improved the ability of students to write to members of the lay public.