不同年龄段人体脉搏的测量与分析

人体内部各器官的健康状态可以在脉搏信息中反映出来,要使脉诊技术客观化,除了获取准确的脉搏信息外,还必须对大量不同人群的脉搏信息进行对比分析,提取有关的特征参量。利用PVDF压力传感器并垫一水囊间接接触法拾取脉搏信息,通过调理放大硬件电路和数据采集处理系统实现人体脉搏的测量,给出了不同年龄段人群的脉图及对应的频谱图,并进行了对比分析。     

一种动物实验监控系统的设计

本文主要设计动物生命体征参数（体温、呼吸率和脉搏率）的监控系统。硬件电路采用MSP430F5438芯片作为微控制器,体温、呼吸和脉搏生理参数的信号采集使用了相应的信号调理电路和处理电路,主要由电信号转换电路、放大滤波电路、AD转换电路、脉冲转换电路、LCD显示电路、加热垫和蜂鸣器驱动电路等组成。     

脉搏图参数的自动测算

中医脉象的现代研究,常需测算大量的脉搏图(简称脉图)参数,费功费时,有必要引入计算机来自动测算。目前计算机对脉图的自动识别,还只能判别4个特征点,而对变化最活跃的、可能具有较多信息的潮波却不能识别。我们因工作需要,对该课题进行了研究,并取得初步成功。     

人体脉搏的测量与分析

人体脉搏信息反映了人体内部各器官的健康状态。本文介绍了一种用压力传感器实现脉搏测量的系统设计及测量方法,并对测量的脉搏信号进行了频谱分析和讨论,其分析结果与人体生理状况是相符的。     

人体脉象仪动态测量分析系统研制成功

上海重旦大学麦克公司自行研制成功人体脉象动态测量分析系统。该系统选用的传感器和信号放大、转换系统能有效地接收人体挠动脉处的脉博信号,并将此信号用脉图曲线的形成显示出来,实现了将被检测者实     

高血压患者脉搏波参数与脉搏波传导速度的相关性研究

目的:探讨高血压患者脉搏波参数与脉搏波传导速度的相关性,为从脉图上辨识高血压病及脉搏波参数的拓展应用提供参考。方法:选择2012年6月至2013年6月在北京安贞医院和北京人民医院门诊和住院确诊的原发性高血压患者32例作为实验组,并招募健康成人志愿者29例作为对照组。利用中医四诊合参辅助诊疗仪与皮尺分别采集两组受试者的左侧寸口脉图信息和主动脉至桡动脉的血管长度,计算脉搏波参数及脉搏波传导速度,采用方差分析和皮尔逊简单相关的统计方法分析高血压患者不同的脉搏波参数与其脉搏波传导速度的相关性。结果:与对照组比较,实验组的PWV显著升高,有显著性差异(P0.05)。实验组H2/H1明显高于对照组(P0.05),但H4/H1、T1/T、T2/T比值均显著低于对照组(P0.05),差异均有显著性意义(P0.05)。高血压患者的H2/H1、T1/T、T2/T、H4/H1均与其PWV相关,其中H2/H1与PWV呈显著正相关(P0.05),T1/T、T2/T与PWV呈显著负相关(P0.05),H4/H1与PWV呈一般正相关(P0.05)。结论:高血压患者的脉搏波参数与脉搏波传导速度具有显著相关性,且潮波出现的幅值与脉搏波传导速度有显著正相关;脉搏波上升支和潮波的时值与脉搏波传导速度具有显著负相关,重搏波相对高度与脉搏波传导速度具有一般相关关系,因而可通过脉搏波参数的变化了解高血压患者血管弹性的状态。     

基于血流多普勒原理的血压测量系统设计

血流信号的采集可基于超声多普勒技术。利用多普勒超声探头在肢体主动脉脉搏处采集到血流多普勒频移信号,对信号电压进行放大,一方面直接输入扬声器转变为音频信号,得到多普勒音;同时用频率/电压变换器LM331变换多普勒频移信号,得到脉搏波信号。基于此原理,设计了使用无创、直观的方法获得肢体血流参数,并经PC机处理,最终在显示器上显示脉搏波形和血压数值的方法。     

亚健康状态物理疗法的研究进展及展望

亚健康是指人体处于健康和疾病之间的一种状态,由于形成亚健康原因的复杂性,针对亚健康的调理方式也多种多样。在简述了亚健康的概念及其形成的原因后,主要介绍了针对亚健康状态的传统物理疗法和现代物理疗法两种方式的特点及疗效,并提出了一种新的调理亚健康的方式即光子中医信息疗法,介绍了该疗法的由来、机理以及在调理亚健康状态方面具有的优势。     

不同品牌胎牛血清用于肺炎链球菌调理吞噬作用的比较

目的 比较不同品牌的胎牛血清用于HL-60细胞分化,以及配制成调理缓冲液后对肺炎链球菌调理吞噬杀菌力的影响。方法 采用5个不同品牌(品牌1~5)的胎牛血清用于HL-60细胞分化培养液和调理缓冲液的配制,计算分化后细胞活力,并进行肺炎链球菌调理吞噬杀菌试验,比较对照孔菌数和质控血清的调理指数。结果 与品牌1胎牛血清分化细胞的活力相比较,品牌5分化的细胞活力差异具有统计学意义(P=0.023,P<0.05),而品牌2、3、4分化细胞的活力差异均不具有统计学意义(P=0.129、0.186、0.440,P>0.05);使用品牌5分化的细胞,对3、6A、7F、9V、14、18C、19A、19F血清群/型调理指数因为调理吞噬后菌落数过少,无法计算。使用品牌5配制的调理缓冲液,对3、9V、19F血清群/型调理指数因为调理吞噬后菌落数过少,无法计算。结论 为保障肺炎链球菌调理吞噬试验的稳定性,建议对试验过程中使用的胎牛血清进行筛选。     

基于生理征象变化的心理测试技术研究进展

本文从心理测试技术的起源和早期应用入手,介绍了心理状态与皮肤电、心率、脉搏、血压、呼吸、眼动等生理指标的关系,阐述了心理变化与生理征象变化之间的密切关系,揭示了心理测试技术的生理学依据.通过分阶段对萌芽期、近代、现代和当代心理测试仪器的设计思路和原理介绍,结合对典型的机械式、电子式和多元化测试仪器的功能,较为充分的展示了心理测试技术的研究进展及其在测试仪器改进上的体现.文章还介绍了基于脑电信号、事件相关电位、功能磁共振成像、核磁共振、皮肤温度、语音次声波等生理参数设计的正处于研发阶段的新型测试仪,并展望了心理测试技术发展和应用前景.     

脉搏波时标对臂踝脉搏波传播速度测量的影响

臂踝脉搏波传播速度(brachial-ankle pulse wave velocity,baPWV)测量是一种便捷、无创的方法,可用于人体动脉硬化度的评估,在临床和科学研究中广泛应用于血管早期病变的筛查和心血管系统风险的评估。本文设计开发了人体上臂和踝部脉搏波波形采集系统,并利用该系统对59名健康成年人进行实验,研究了目前三种最常用的脉搏波时标(pulse timing mark,PTM)定义方法对baPWV测量的影响。实验结果表明,选用不同的PTM方法所测得的baPWV结果具有显著的差异性(P0.001)。而且,PTM方法的不同还影响到了baPWV与年龄、血压的相互关系。     

Programming Microbes Using Pulse Width Modulation of Optical Signals

Cells transmit and receive information via signalling pathways. A number of studies have revealed that information is encoded in the temporal dynamics of these pathways and has highlighted how pathway architecture can influence the propagation of signals in time and space. The functional properties of pathway architecture can also be exploited by synthetic biologists to enable precise control of cellular physiology. Here, we characterised the response of a bacterial light-responsive, two-component system to oscillating signals of varying frequencies. We found that the system acted as a low-pass filter, able to respond to low-frequency oscillations and unable to respond to high-frequency oscillations. We then demonstrate that the low-pass filtering behavior can be exploited to enable precise control of gene expression using a strategy termed pulse width modulation (PWM). PWM is a common strategy used in electronics for information encoding that converts a series of digital input signals to an analog response. We further show how the PWM strategy extends the utility of bacterial optogenetic control, allowing the fine-tuning of expression levels, programming of temporal dynamics, and control of microbial physiology via manipulation of a metabolic enzyme.     

Impact of Innovative Pulse Oximeter Sensor Management Strategy

Background:Following a merger of two children''s hospitals, leadership discovered a considerable utilization volume of single-use sensors that was associated with declining hospital reimbursements. This discovery resulted in the establishment of a new sensor management strategy, the goal of which was to decrease costs and waste associated with disposable pulse oximetry sensors.Implementation:The sensor management strategy involved using replacement tapes with single-patient-use pulse oximeter sensors instead of the current practice of reprobing with a new sensor. A 60% utilization goal was set, with the focus shifted from sensors used per patient to replacement tapes per sensor.Results:The implementation of a new sensor management strategy between the years 2006 and 2019 in a hospital system decreased sensor volume by more than 780,000 sensors and realized a cost avoidance of more than 7 million dollars.Conclusion:A sensor management strategy can substantially reduce the cost and medical waste commonly associated with the use of disposable, single-patient pulse oximetry sensors.

In 2002, a merger occurred between the Minneapolis Children''s Medical Center and St. Paul Children''s Hospital. Both hospitals had pulse oximetry monitors and equipment in place; however, they used two different oximetry sensor platforms. Minneapolis Children''s used a multisite reusable sensor with a replacement tape and an accompanying sensor management plan, whereas St. Paul Children''s used single-patient disposable adhesive sensors with a recycling/processing program.Following the merger of the two hospitals, it became apparent to the new leadership team that the national trend was to adopt pulse oximetry as a standard of care in routine vital sign assessment. With this adoption, reimbursements decreased, and what was previously a revenue stream for the hospitals had become an operating expenditure. As a result, these financial disparities prompted leadership to initiate a capital project to standardize pulse oximetry with a focus on technology and cost containment.     

Analysis of Wrist Pulse Signal: Emotions and Physical Pain

BackgroundPulse diagnosis (wrist pulse signal) is a well-known traditional technique used for a health examination. It has the potential to detect cardiac and non-cardiac diseases.ObjectiveA study was conducted to investigate human emotions using wrist pulse signal assessment. The aim was to categorize anxiety, boredom, physical pain, and reference state by processing and analysis of acquired signals.MethodA protocol was designed to induce emotions. Data were acquired from 24 healthy volunteers. Signals were processed and further analyzed using paired t-test and Analysis of Variance (ANOVA). Machine learning algorithms, Linear Discriminant Function (LDF), Quadratic Discriminant Function (QDF), and Support Vector Machine using kernel Gaussian radial basis function (RBF-SVM) were used to evaluate significant features and classify the emotions.ResultsComputing significant plus ranked features performed better over randomly selected features for pairwise emotion classification. Here, the QDF classifier outperforms LDF. Additionally, ANOVA validated the effectiveness of statistically prominent features to classify emotional states. Ratio_Pulse_Strength, total_power, Spectral Entropy, and meancd5 came out as the four most significant features to classify the emotion “Anxiety”, “Boredom”, “Pain”, and “Reference” with positive prediction rate of 100%, 73%, 100%, and 86% respectively using RBF-SVM in the user-independent model.ConclusionPreviously, WPS has been used mainly to detect physical abnormality in the human body. The results endorse the potential of user-independent human emotion detection using a wrist pulse signal. The present work was focusing on a few emotional states. Results are encouraging and may be well applied to many more states.     

具脉冲出生的Leslie-Gower捕食者-食饵系统的动力学分析

研究了一个具有脉冲出生的Leslie-Gower捕食者一食饵系统的动力学性质．利用频闪映射。得到了带有Ricker和Beverton-Holt函数的脉冲系统准确的周期解．通过Floquet定理和脉冲比较定理,讨论了该系统的灭绝和持久生存．最后,数值分析了以b（p）为分支参数的分支图,得到的结论是脉冲出生会带给系统倍周期分支、混沌以及在混沌带中出现周期窗口等复杂的动力学行为．     

具脉冲出生单种群模型的脉冲收获阈值分析

讨论了与生物资源管理相关的具脉冲出生与脉冲收获的单种群动力学模型,利用离散动力系统频闪映射理论,得到了生物资源管理控制阈值的充分条件.结论为现实的生物资源管理提供了可靠的策略依据,也丰富了脉冲微分方程理论.     

具有脉冲出生和脉冲接种的SIR传染病模型

考虑了脉冲出生、脉冲接种、垂直传染、因病死亡等因素,建立了脉冲出生和脉冲接种同时进行的SIR传染病模型,通过分析无病周期解的存在性以及稳定性,得出疾病灭绝的条件.     

污染环境中具有生育脉冲的单种群模型的最优捕获问题

研究周期性脉冲毒素输入的污染环境中具有生育脉冲的单种群捕获模型的动力学性质,通过数值模拟给出所研究系统的动力复杂性,并进一步指出脉冲捕获的时间对最大年度持续产量的影响.