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1.
Kocatürk PA Siklar Z Kavas GO Dallar Y Tanyer G 《Biological trace element research》2002,90(1-3):39-46
Children with growth dysfunction present complex diagnostic challenges. The purpose of this study was to determine the effects
of oral zinc treatment on red cell copper/zinc superoxide dismutase (Cu/Zn-SOD) activity and copper and zinc concentrations
in children with “growth retardation.” Twenty-nine patients, average age of 11 yr, whose percentile was under 3% of the National
Center of Health Statistics parameters were selected. For the control group, 10 children whose average age was 10 yr were
included.
Red cell Cu/Zn-SOD activity was determined by spectrophotometer. Red cell copper and zinc concentrations were measured by
atomic absorption spectrophotometer. Red cell Cu/Zn-SOD activity was higher than the control group before zinc treatment (p<0.001). There was a decrease in the Cu/Zn-SOD activity after zinc treatment, but the mean value of the Cu/Zn-SOD activity
of patients was still higher than the control values (p<0.001). After zinc treatment, there was an increase in red cell zinc concentration (p<0.01) and a decrease in copper concentration (p<0.001), which were statistically significant. The results of this study suggested that Cu/Zn-SOD activity was increased significantly
during growth retardation and zinc treatment appeared to ameliorate the enzyme activity. There were also insignificant alterations
in red cell copper and zinc concentrations.
Presented at the 23rd Congress of Endocrinology and Metabolic Diseases of Turkey Joint Meeting with the European Federation
of Endocrine Societies, Bilkent Hotel, Ankara, 7–9 September, 2000. 相似文献
2.
The plasma and erythrocyte levels of zinc, copper, and magnesium and the activities of red-cell copper-zinc superoxide dismutase
(Cu/Zn-SOD) and catalase (CAT) were determined in patients with benign and malignant tumors of the larynx. Blood samples from
patients and healthy controls were drawn using heparinized tubes. The erythrocyte Cu/Zn-SOD and CAT activities were determined
spectrophotometrically and the zinc, copper, and magnesium concentrations were determined in erythrocyte and plasma by atomic
absorption spectrometry. Variance analysis was employed in the statistical evaluation of the findings.
There was a significant increase in red-cell Cu/Zn-SOD activity in the subjects with malignant and benign tumors compared
to controls (p<0.001). The CAT activity increased only in the benign tumor group (p<0.01). The plasma zinc concentrations were significantly lower in the malignant tumor group (p<0.05) and significantly higher in the benign tumor group (p<0.01). The erythrocyte copper concentrations were significantly lower in both benign and malignant tumor groups (p<0.001). The plasma copper and magnesium and the erythrocyte magnesium concentrations did not show significant differences
relative to controls (p>0.05).
The increases in the activities of SOD and CAT activities and the changes in trace elements concentrations can indicate the
presence of increased reactive oxygen species that might play a part in the pathogenesis larynx tumors.
Presented at the IX Asian-Pacific Congress of Clinical Biochemistry, March 9–14, 2002, New Delhi, India. 相似文献
3.
Hypertension: does impaired endothelium-dependent relaxation affect superoxide scavenging? 总被引:3,自引:0,他引:3
The purpose of this study was to investigate the effects of acute nitric oxide synthase inhibition on mean arterial blood
pressure, oxidative stress markers such as plasma malondialdehyde (MDA) concentration, intracellular antioxidant enzyme activities
such as copper-zinc superoxide dismutase (Cu/Zn SOD) and catalase and on trace elements important for activity and stability
of Cu/Zn-SOD.
Wistar-Kyoto rats (approx 150 g) (n=11) were treated with N
ω-nitro-l-arginine methyl esther (l-NAME) (0.5 mg/mL) for 2 d. Age- and bodyweight-matched rats (n=10) were used for control group. Their systolic blood pressures and heart rates were recorded daily during the experimental
period and also before their blood samples were drawn. Plasma MDA, plasma and red cell zinc and copper concentrations, and
red cell Cu/Zn-SOD and catalase activities were determined.
A progressive rise in systolic arterial blood pressure was observed compared to the control group (p<0.001). The heart rate of the experimental group was reduced on the third day (p<0.05). Plasma MDA concentration and red cell catalase activity were increased in the experimental group (p<0.001 and p<0.001, respectively). Plasma copper and red cell zinc concentrations were also increased significantly in the experimental
group (p<0.001 and p<0.01, respectively).
In conclusion, impairment in endothelium-derived relaxation altered mean arterial blood pressure, oxidant status, and trace
element concentrations.
Presented at the Advanced Course (sponsored by NATO-ASI, SFRR, FEBS, UNESCO-MCBN, IUBMB) “Free Radicals, Nitric Oxide, and
Inflamation: Molecular, Biochemical, and Clinical Aspects,” Lara, Antalya, Turkey, September 23–October 3, 2001. 相似文献
4.
Pelin Aribal Kocatürk M. Cenk Akbostanci Canan Işikay Aylin Öcal Deniz Tuncel Güzin Özelçi Kavas Nermin Mutluer 《Biological trace element research》2001,80(2):115-124
Ischemia is associated with the pathological changes caused by the accumulation of reactive oxygen metabolites (ROM) in cerebrovascular
accident (CVA). The aim of this study was to determine red cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase
activities and copper and zinc concentrations both in plasma and in red cells in CVA. Cu/Zn-SOD and catalase activities of
16 patients, with an average age of 64 yr, were measured spectrophotometrically; copper and zinc concentrations were determined
by atomic absorption spectrophotometer. The results showed that Cu/Zn-SOD activity was increased markedly in patients compared
to the young controls and reached a peak on the d 5 of the disease, whereas the catalase activity of the patients on d 3 and
d 5 were in the normal range, but higher on d 10. The enzyme activities of the elderly group were generally increased compared
to the young controls. Copper and zinc concentrations showed corresponding alterations. These findings suggested that the
effects of oxidative stress in CVA might be reflected in red cell and plasma parameters.
Presented at the III International Congress of Pathophysiology, Lahti, Finland, 28 June–3 July, 1998. 相似文献
5.
The aim of the present study is to evaluate the status of plasma essential trace element selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these elements on oxidative status in patients with childhood
asthma. Plasma Se, Mn, Cu, and Zn concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations,
malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric method. The plasma MDA/TAC
ratio was calculated as an index of oxidative status. Plasma albumin levels were measured to determine nutritional status.
Plasma Fe concentrations, MDA levels and the MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to
be significantly different in patients and controls (p>0.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and Se (r=0.485, p<0.021), and a negative correlation between TAC and MDA values (r= −0.337, p<0.031) in patients with childhood asthma. However, there was no correlation between these trace elements and albumin content
in patient groups. These observations suggest that increased Fe and decreased Se concentrations in patients with childhood
asthma may be responsible for the oxidant/antioxidant imbalance. 相似文献
6.
Kuru O Sentürk UK Gündüz F Aktekin B Aktekin MR 《Biological trace element research》2003,93(1-3):105-111
Trace element content of different tissues might be altered by both age and exercise training. We aimed to determine the effects
of a 1-yr swimming protocol (60 min/d, 5 day/wk) on tissue levels and the distribution of zinc (Zn), magnesium (Mg), and copper
(Cu) in aging rats. Three groups were formed: sedentary and trained old groups and a young control group. Tissue Zn, Mg, and
Cu concentrations were measured in the kidney, heart, liver, lungs, and gastrocnemius and soleus muscles. Kidney zinc concentration
significantly decreased in the sedentary old group compared to the young control group (p<0.01) and was significantly higher in the trained old group compared to the sedentary old group (p<0.01), whereas Zn levels in the soleus muscle significantly increased in the sedentary old group in comparison to young controls
(p<0.05). Tissue Mg concentrations remained unchanged. The sedentary old group exhibited a significant decrease in kidney Cu
concentration compared to the young control group (p<0.01). Although kidney Cu levels also decreased in trained old rats in comparison to young controls (p<0.05), they were significantly higher than in sedentary old rats (p<0.01). The decrease in kidney Zn and Cu content as a result of aging was partly prevented by long-term swimming exercise. 相似文献
7.
The aim of the present study is to evaluate the status of plasma essential trace elements selenium (Se), zinc (Zn), copper
(Cu), and iron (Fe) concentrations and their related acute-phase proteins, ceruloplasmin (Cp), ferritin, transferrin (Tf),
and albumin levels in patients with vivax malaria. Plasma Cu and Zn concentrations were determined by atomic absorption spectrometry
(AAS). Se concentrations were determined by graphite furnace AAS. Fe, Cp, Tf, and albumin levels were determined by colorimetric
methods. Plasma Se, Fe, and albumin levels were found to be significantly lower (p<0.01, p<0.001, and p<0.05, respectively) and Cu, Cp, and ferritin levels and Cu/Zn ratios were significantly higher (p<0.001, p<0.001, p<0.001, and p<0.05, respectively) in patients when compared with those of healthy subjects. Plasma, Tf, and Zn levels were not found to
be significantly different (p>0.05) in patients and controls. There were positive important correlations between Cu and Cp (r=0.908, p<0.001), Zn and albumin (r=0.633, p<0.001), and negative correlations between Fe and ferritin content (r=−0.521, p<0.05) and Fe and Tf (r=−0.616, p<0.01) in the patients group. Our findings demonstrated that plasma essential trace elements Se, Cu, and Fe change, but these
changes might be dependent on acute-phase proteins, which were regulated as a part of defense strategies of the organism,
induced by hormonelike substances. 相似文献
8.
In this study, we investigated the impact of ischemia-reperfusion on antioxidant enzyme activities and trace element concentrations.
For this purpose, ischemia was initiated by clamping superior mesenteric artery of Wistar (albino) rats for 30 min, followed
by reperfusion for 20 min. Immediately after reperfusion, blood samples were taken and examined for red cell copper-zinc superoxide
dismutase (Cu-Zn-SOD), catalase (CAT), and glutathione peroxidase (GPx) activities spectrophotometrically and plasma zinc,
copper, and magnesium concentrations by atomic absorption spectrophotometer. In the ischemiareperfusion group, red cell Cu-Zn-SOD
activity and plasma zinc and copper concentrations were increased significantly (p<0.001) when compared to the control group; however, the increases in GPx activity and plasma magnesium concentration were
not significant (p>0.05). We also found a significant (p<0.01) decrease in catalase activity. Free radicals released as a consequence of ischemia-reperfusion caused significant alterations
in antioxidant enzymes and in the concentrations of trace elements.
Presented at III International Congress of Pathophysiology 1998, Lahti, Finland. 相似文献
9.
Navarro-Alarcon M Reyes-Pérez A Lopez-Garcia H Palomares-Bayo M Olalla-Herrera M Lopez-Martinez MC 《Biological trace element research》2006,113(3):209-222
A 6-mo longitudinal study of 48 hemodialysis patients (HPs) with chronic renal failure was performed. Three blood samplings
were done. Samples of whole blood from each patient were collected during hemodialysis sessions after passing through the
artificial kidney. Zinc and copper levels were measured by atomic absorption spectrometry. Additionally, 36 biochemical indexes
were evaluated during the study. Fifty-two healthy matched controls were also considered. Mean serum zinc and copper concentrations
in HPs were significantly decreased (Zn) and increased (Cu), when compared with healthy controls (p<0.01). Zinc concentrations found in the first and second blood samplings from patients were significantly lower than those
measured for the third sampling (p<0.01). The etiology of chronic renal failure influenced the statistically serum Zn levels of patients (p<0.05). Serum copper levels of HPs were significantly diminished by the existence of secondary associated diseases (p<0.01). Uric acid and parathyroid hormone, and total-cholesterol and glutamic-pyruvic-transaminase levels were significantly
(p<0.05) and linearly related with serum zinc and copper concentrations, respectively. From all of indexes, creatinine, direct
bilirubin, magnesium, calcium, parathyroid hormone, transferrin, and albumin were statistically modified along the longitudinal
study (p<0.05). Transferrin serum levels were significantly diminished in the third blood sampling, indicating the tendency toward
anemia in the patients. This result is reinforced by low levels of biochemical and hematological indexes related with iron
body staus. 相似文献
10.
The levels of, zinc, copper, Fe, Zn, Cu, Mn, Mg, K, Na, and Cl and the activity of carbonic anhydrase were determined in lambs
with pneumonia. A significant decrease of p<0.01 level in Zn concentration, in Cu level (p<0.001) and significant increases in K and Na levels (p<0.05) and of the Cu/Zn ratio (p<0.001) were observed in the study group. The carbonic anhydrase activity was decreased in the study group, but the decrease
was not statistically significant (p>0.05). Also, nonsignificant decreases of Fe, Mg, and Cl and increase of the Mn concentration were also observed in the lambs
with pneumonia (p>0.05). Our results suggest that the significant element changes reported here and the Cu/Zn ratio, but not the activity of
carbonic anhydrase, can be used as indicators of pneumococcal infection. 相似文献
11.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
12.
Olusi S Al-Awadhi A Abiaka C Abraham M George S 《Biological trace element research》2003,91(2):137-144
Leptin, the obesity gene protein product, is a hormone with multiple physiological functions in the human. However, there
are few reports in the literature on its role in trace element metabolism in the normal population. Therefore, we investigated
the association among serum leptin, zinc, copper, and zinc/copper ratio in 570 healthy men and women aged 15 yr and older.
Serum leptin assay was done with a commercial enzymelinked immunosorbent assay kit; serum zinc and copper levels were measured
by an atomic absorption spectrophotometer. Serum leptin was found to be positively associated with age (r=0.254, p<0.001), sex (r=0.406, p<0.001), body mass index (BMI) (r=0.553, p<0.001), and serum copper (r=0.419, p<0.001), but negatively associated with the zinc/copper ratio (r=−0.423, p<0.001). There was no significant association between serum leptin and zinc (r=−0.131, p>0.05). When the confounding effects of age, sex, and BMI were removed, serum leptin was still positively associated with
serum copper (r=0.197, p=0.02) and the serum zinc/copper ratio (r=−0.182, p=0.03). These results suggest that copper and not zinc has an effect on serum leptin levels. 相似文献
13.
Idris Yücel Fikret Arpaci Ahmet Özet Bülent Döner Turan Karayilanoĝlu Ahmet Sayar Önder Berk 《Biological trace element research》1994,40(1):31-38
Serum copper, zinc levels, and the Cu/Zn ratio were evaluated in 31 patients with breast cancer and 35 healthy controls. Copper and zinc were determined by atomic absorbtion spectrophotometry. The mean serum copper level and the mean Cu/Zn ratio in patients with breast cancer were significantly higher than the control group (p<0.001 andp<0.001). In addition, the mean serum zinc level in patients with breast cancer was significantly lower than the control group (p<0.001). Neither serum copper and zinc levels nor the Cu/Zn ratio were of value in discriminating of the disease activity and severity. Interestingly, the Cu/Zn ratio in premenopausal patients was higher than postmenopausal patients (p<0.05) and this was not related to age. The further combined biological and epidemiological studies are necessary to investigate the roles of copper and zinc in breast cancer. 相似文献
14.
Feridun Kosar Ibrahim Sahin Nusret Acikgöz Yuksek Aksoy Zehra Kucukbay Sengul Cehreli 《Biological trace element research》2005,107(1):1-9
It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes
in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of
selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients
had significantly lower serum concentrations of Se and Zn than control subjects (p<0.05 and p<0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93±0.59
μg/L vs 1.06±0.29 μg/L; p<0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70±0.92 vs 1.68±0.45; p<0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity
classes (p>0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We
suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high
Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease. 相似文献
15.
Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood
levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in
women with preeclampsia and in women with healthy, normotensive pregnancies.
For the patients with preeclampsia compared with controls, significantly higher mean plasma levels were found of homocysteine
(16.39 vs 9.45 nmol/mL; p≤0.001), zinc (15.53 vs 11.93 μg/g protein; p < 0.05), and copper (47.90 vs 31.60 μg/g protein; p=0.001). The ratio of plasma Cu/Zn levels tended to be higher in preeclamptic women and could be taken as an index of inflammatory
reaction, but the difference was not significant. Homocysteine concentrations correlated positively with plasma zinc concentrations
in women with preeclampsia (r=0.588, p=0.003) but not in women with healthy pregnancies. No correlations were observed between plasma levels of homocysteine and
copper.
Thus, the present study found evidence that preeclampsia might be associated with hyperhomocysteinemia and elevated blood
levels of zinc and copper. Furthermore, elevated blood levels of zinc were significantly associated with hyperhomocysteinemia
in preeclampsia. More studies are warranted to investigate further any relationship between altered homocysteine metabolism
and levels of zinc and copper in preeclampsia. 相似文献
16.
Essential elements, mainly selenium and zinc, were involved in protection against oxidative stress in cells. Oxidation could
lead to the formation of free radicals that have been implicated in the pathogenesis of many diseases, including leukemia.
Leukemia is a neoplastic disease that is susceptible to antioxidant enzyme and essential elements alterations. This study
was undertaken to examine the levels of essential elements, antioxidant enzymes activities, and their relationships with different
types of leukemia. Serum selenium, zinc, and copper concentrations, red blood cell glutathione peroxidase (GPx) activities,
plasma Cu−Zn superoxide dismutase (Cu−Zn SOD) activities and lipid peroxidation (LPO) levels were determined in 49 patients
with different types of leukemia before initial treatment. Serum selenium and zinc concentrations were lower in leukemia patients
than those of controls (p<0.01). Serum copper concentration was higher in leukemia patients than that of controls (p<0.01). The activities GPx and Cu−Zn SOD were significantly increased in leukemia patients, especially with acute leukemia
(AL), acute lymphoid leukemia (ALL), and acute nonlymphoid leukemia (ANLL) (p<0.05), whereas no difference was found between those of chronic myelogeneous leukemia and the controls. The levels of LPO
were normal as controls. Serum selenium concentration was not correlated with GPx, and serum levels of zinc and copper were
not related to Cu−Zn SOD. Serum zinc levels had a negative correlation with the absolute peripheral blast cells, whereas serum
copper had a positive correlation with the absolute peripheral blast cells. Increased GPx and Cu−Zn SOD activities and normal
levels of LPO, which were a protective responses, were an indicator of mild oxidative stress; it mights indicate that the
essentials elements alterations in leukemia patients were mostly dependent on tumor activity. Changes of their levels demonstrated
that there are low selenium, zinc, and high copper status in leukemia patients. The decrease of plasma zinc and increase of
the Cu/Zn ratio could be the index that showed an unfavorable prognosis of acute leukemia. 相似文献
17.
Ze-peng Y Guo-wei L Hong-yu H Yun-yu W Yong-hui S 《Biological trace element research》2005,105(1-3):215-227
This experiment was conducted to investigate the effects of zinc sulfate and zinc methionine (Zn-Met) and their levels on
apoptosis induced by glucocorticoid of thymocytes and the possible mechanism. Dexamethasone was used to make the apoptosis
model of thymocytes; zinc sulfate and zinc methionine were supplemented to the medium at levels of 0,50, 100, 500, and 1000
μM. The activity of cells,Cu,Zn superoxide dismutase (Cu,Zn-SOD), DNA ladder pattern, intracellular calcium concentration, and
the percentage of apoptosis nuclei were determined.
Both ZnSO4 and Zn-Met could modulate apoptosis; they inhibited apoptosis and decreased DNA fragmentation. The regulation was concentration
dependent. At levels of 50 and 100 μM, the effect of Zn-Met on inhibiting apoptosis was less efficient than that of ZnSO4 (p<0.05), but the activity of the cells cultured with Zn-Met was higher than those cultured with ZnSO4; they showed no difference in modulating apoptosis when added at levels of 500 and 1000 μM to the medium (p>0.05). Intracellular calcium concentrations of cells cultured with Zn-Met were higher than those cultured with ZnSO4 at the same levels. Zinc supplementation decreased the concentration of intracellular calcium significantly (p<0.05) and increased the activity of Cu,Zn-SOD in the extract of the cells (p<0.05). Both zinc sulfate and Zn-Met could modulate apoptosis of thymocytes induced by glucocorticoid; the mechanism might
involve the exchange of intracellular calcium, the redox of cells, and the two forms of zinc might go different ways in the
regulations. 相似文献
18.
Safiye Tuncer Ayhan Kamanli Ethem AkÇil Güzin özelÇi Kavas Bülent SeÇkin Mesut Birol Atay 《Biological trace element research》1999,68(2):137-142
It has been suggested that reactive oxygen metabolites and trace elements play some role in the etiology and pathogenesis
of rheumatoid arthritis (RA). Superoxide dismutase (SOD) is believed to exert an important protective role against oxygen
toxicity. The aim of the study was to investigate the probable changes in the levels of trace elements and SOD activity in
RA. Plasma and erythrocyte copper, zinc, and magnesium levels and erythrocyte SOD activity were measured in groups of controls
and RA cases. Significantly increased erythrocyte SOD activity was found in RA patients in comparison with controls(p < 0.0001). A rise in erythrocyte Zn level(p < 0.0001) and plasma Cu level(p < 0.0001) and a decrease in erythrocyte Cu level(p < 0.05) and plasma Zn level(p < 0.05) were obtained in RA patients when compared to controls. Plasma and erythrocyte Mg levels of the RA patients showed
slight and statistically insignificant reductions when compared to controls(p > 0.05). In RA patients, there were positive correlations between erythrocyte SOD activity and Mg level (r = 0.4345,p < 0.01) and between erythrocyte Zn level and plasma Cu level(r = 0.4132,p < 0.01). There were negative correlations between erythrocyte SOD activity and plasma Zn level(r =-0.3605,p < 0.05) and between plasma Zn level and erythrocyte Cu level(r =-0.4578,p < 0.01) in RA patients.
This work was presented at the International Congress on Free Radicals in Health and Disease, 6–10 September 1995, Istanbul,
Turkey. 相似文献
19.
Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between
zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination
due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated
as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group
(n=14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal
triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations
were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were
measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48±15.9 vs 102.6±23.7
and 55.16±11.3 vs 77.4±5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation
between serum zinc and selenium levels, and serum copper levels (r=−425 and −0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic
mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and
vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered
for the further decrease in the recurrence and occurrence of NTDs. 相似文献
20.
Aydin Ece Bekir Sami Uyamik Akin IŞcan Pelin Ertan M. Ramazan Yiğitolu 《Biological trace element research》1997,59(1-3):31-39
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. 相似文献