Prevention of Postoperative Deep Venous Thrombosis and Pulmonary Embolism

Two series of patients observed clinically and by phlebography suggest that one agent known to produce a reduction in platelet aggregation in vitro might be useful in reducing the incidence of deep venous thrombosis and pulmonary embolism postoperatively. The agent used in this study was hydroxychlorquine sulphate.     

肺栓塞的诊治和预防策略

急性肺栓塞(PE)是一种心血管疾病突发事件,具有较高的发病率和死亡率。一旦发生PE,快速、有效的诊治是挽救PE患者生命的关键,但也是呼吸内科医生一直面临的挑战。尽管PE的诊断手段和评估方法已经取得了很大地进步,但由于PE患者临床表现的非特异性和诊断方法的多样、复杂性,如何采取及时、有效的诊治策略仍是呼吸内科医生面临的重要难题。与此同时,由于PE诊断困难,治疗风险大,也使其临床预防势在必行。鉴于此,本文综述了当前欧洲心脏病学会(ESC)等国际心血管研究机构发布的PE诊治指导方针和研究进展,为读者进一步认识和掌握PE快速、有效的诊治和预防策略提供参考。     

Resolution of Pulmonary Embolism

To assess restoration of pulmonary perfusion after pulmonary embolism serial lung scans were carried out on 74 patients. Of these, one-third showed almost complete recovery, one-third improved, and the remainder either failed to improve or became worse. Perfusion was most rapidly restored in the first few days after the embolus and more slowly during the next two to three weeks.Untreated patients improved less often and had more new defects in perfusion than patients treated with anticoagulant therapy, no difference occurring in either the amount of improvement or in the rate of recovery of perfusion between patients treated with different anticoagulant regimens. There was evidence of further pulmonary emboli in 35% of treated patients, 82% of these occurring within two weeks of the initial embolus. Patients with defects in perfusion greater than 30% showed considerable improvement but recovered less well than those with smaller defects.