PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells

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An evolved AAV variant enables efficient genetic engineering of murine T cells

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The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage

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Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

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Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

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Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

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Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

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PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease

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KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation

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Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

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Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis

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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Large-scale multiplexed mosaic CRISPR perturbation in the whole organism

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Molecular,metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

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High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

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PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

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Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

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