Molecular and functional architecture of striatal dopamine release sites

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Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

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Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry

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Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

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Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

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Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues

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Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

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Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

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Activity- and sleep-dependent regulation of tonic inhibition by Shisa7

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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death,Tissue Damage,and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension

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Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

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A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance

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Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis

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A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration

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Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception

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