共查询到20条相似文献,搜索用时 31 毫秒
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Mastooreh Chamanian Katarzyna J. Purzycka Paul T. Wille Janice S. Ha David McDonald Yong Gao Stuart F.J. Le Grice Eric J. Arts 《Cell host & microbe》2013,13(2):181-192
Highlights? A retroviral RNA packaging element (GRPE) overlaps the Gag-Pol ribosomal frameshift site ? Without two stem loops in GRPE, genomic RNA encapsidation is decreased >50-fold ? Downregulating the translation termination factor eRF1 produces defective virus particles ? GPRE links ribosome frameshifting and effective retroviral packaging 相似文献
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Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
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Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination 相似文献
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Carla Gentile Hana Sehadova Alekos Simoni Chenghao Chen Ralf Stanewsky 《Current biology : CB》2013,23(3):185-195
Highlights? Distinct clock neurons mediate synchronization to high or low temperature cycles ? CRY counteracts the effects of temperature cycles on the molecular circadian clock ? Without CRY, dorsal clock neurons mediate synchronization to all temperature cycles ? CRY’s function in Zeitgeber integration is partially non-cell autonomous 相似文献
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Yifeng Xu Yizhong Wang Hume Stroud Xiaofeng Gu Bo Sun Eng-Seng Gan Kian-Hong Ng Steven E. Jacobsen Yuehui He Toshiro Ito 《Current biology : CB》2013,23(4):345-350
Highlights? The Arabidopsis matrix protein TEK silences transposons and repeat-containing genes ? Binding of TEK on targets affects chromatin conformation and histone modifications ? TEK protein associates with FVE/MSI5-containing histone deacetylation complex ? TEK directs repressive modification as a key structural component in gene silencing 相似文献
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CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells 总被引:1,自引:0,他引:1
Highlights? PS is expressed on the surface of apoptotic and phagocytic cells during apoptosis ? CED-7 and TTR-52 mediate time-dependent loss of PS from surface of apoptotic cells ? CED-7 and TTR-52 promote generation of extracellular PS vesicles ? CED-7/TTR-52/CED-1 promote phagocyte PS expression, important for corpse engulfment 相似文献
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Highlights? Investigated why irrelevant scene attributes influence perception of surface gloss ? Found gloss judgments exhibit complex interactions between illumination and 3D shape ? Four proximal cues can account for interactions between light field, shape, and gloss ? Suggests that these cues mediate the perception and misperception of gloss 相似文献
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Varadharajan Sundaramurthy Rico Barsacchi Nikolay Samusik Giovanni Marsico Jerome Gilleron Inna Kalaidzidis Felix Meyenhofer Marc Bickle Yannis Kalaidzidis Marino Zerial 《Cell host & microbe》2013,13(2):129-142
Highlights? A high-content chemical screen identifies modulators of intracellular mycobacteria ? Three compounds that kill bacteria by altering host processes were validated ? Multiparametric chemical and genetic data sets integrated to identify mode of action ? Modulation of autophagy and endosomal trafficking identified as mode of action 相似文献
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Highlights? C. elegans fertility on different diets requires nuclear receptor nhr-114 activity ? Somatic NHR-114 is necessary to maintain germline stem cells under different diets ? NHR-114 might mediate a detoxification response that preserves the germline ? Bacterial tryptophan metabolites may underlie diet-sensitive nhr-114(?) sterility 相似文献
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Highlights? An invertebrate model for studying appetitive stimulus-driven feeding is presented ? Perception of appetitive olfactory inputs requires dopamine and NPF activities ? Dopamine neurons postsynaptic to projection neurons mediate odor-induced appetite ? NPF and its receptor NPFR1 define a gating mechanism in dopamine neurons 相似文献
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Nathan F. Putman Kenneth J. Lohmann Emily M. Putman Thomas P. Quinn A. Peter Klimley David L.G. Noakes 《Current biology : CB》2013,23(4):312-316
Highlights? Sockeye salmon use geomagnetic imprinting as a homing mechanism ? The homing route of salmon is predicted by magnetic field drift (secular variation) 相似文献
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Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
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Wei-Hao Shang Tetsuya Hori Nuno M.C. Martins Atsushi Toyoda Sadahiko Misu Norikazu Monma Ichiro Hiratani Kazuhiro Maeshima Kazuho Ikeo Asao Fujiyama Hiroshi Kimura William C. Earnshaw Tatsuo Fukagawa 《Developmental cell》2013,24(6):635-648
Highlights? Chromosome engineering efficiently generates neocentromeres in chicken DT40 cells ? CENP-A reproducibly occupies an ~40 kb genomic region at each neocentromere ? Nonkinetochore CENP-A appears to function as a seed for neocentromere assembly 相似文献
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Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
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Suvendu Lomash Sagar Chittori Patrick Brown Mark L. Mayer 《Structure (London, England : 1993)》2013,21(3):414-425
Highlights? The AvGluR1 LBD is a hybrid structure with iGluR prokaryotic and eukaryotic features ? AvGluR1 binds hydrophobic amino acids as well as glutamate ? Chloride ions acts as surrogate ligand atoms in the Ala, Ser, and Met complexes ? The AvGluR1 LBD assembles as a dimer but with very low affinity 相似文献
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Adkar BV Tripathi A Sahoo A Bajaj K Goswami D Chakrabarti P Swarnkar MK Gokhale RS Varadarajan R 《Structure (London, England : 1993)》2012,20(2):371-381
Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation 相似文献
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Bjørn Dalhus Line Nilsen Hanne Korvald Joy Huffman Rune Johansen Forstrøm Cynthia T. McMurray Ingrun Alseth John A. Tainer Magnar Bjørås 《Structure (London, England : 1993)》2013,21(1):154-166
Highlights? Unflipped AP site stabilized by helix-hairpin-helix DNA glycosylase homolog Mag2 ? Nonenzymatic AP site recognition and DNA sculpting ? Sculpting of DNA conformation enhances substrate transfer between proteins 相似文献
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Akira Akamatsu Hann Lin Wong Masayuki Fujiwara Jun Okuda Keita Nishide Kazumi Uno Keiko Imai Kenji Umemura Tsutomu Kawasaki Yoji Kawano Ko Shimamoto 《Cell host & microbe》2013,13(4):465-476
Highlights? Chitin induces rapid activation of the rice small GTPase OsRac1 at the plasma membrane ? OsRacGEF1 interacts with and acts as a guanine nucleotide exchange factor for OsRac1 ? In response to chitin, OsRacGEF1 is activated via phosphorylation by OsCERK1 ? OsRacGEF1 is required for chitin-driven immunity and resistance to rice blast fungus 相似文献