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Chadjichristos C Ghayor C Herrouin JF Ala-Kokko L Suske G Pujol JP Galéra P 《The Journal of biological chemistry》2002,277(46):43903-43917
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Extinction of alpha-fetoprotein gene expression in somatic cell hybrids involves cis-acting DNA elements. 总被引:4,自引:0,他引:4 下载免费PDF全文
alpha-Fetoprotein (AFP), a liver-specific protein, is extinguished in somatic cell hybrids formed by the fusion of mouse hepatoma cells (BWTG3) with rat fibroblast cells (JF1). Our studies show that the extinction of mouse AFP expression in these somatic cell hybrids may involve at least two cis-acting regulatory domains, i.e., the enhancer elements and a tissue-specific promoter region, which are located in the 5'-flanking region of the AFP gene. 相似文献