共查询到20条相似文献,搜索用时 31 毫秒
1.
The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lenssen E James N Pedruzzi I Dubouloz F Cameroni E Bisig R Maillet L Werner M Roosen J Petrovic K Winderickx J Collart MA De Virgilio C 《Molecular and cellular biology》2005,25(1):488-498
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae 总被引:1,自引:0,他引:1
Assenholt J Mouaikel J Saguez C Rougemaille M Libri D Jensen TH 《RNA (New York, N.Y.)》2011,17(10):1788-1794
12.
13.
14.
15.
16.
17.
Panasenko O Landrieux E Feuermann M Finka A Paquet N Collart MA 《The Journal of biological chemistry》2006,281(42):31389-31398
In this work, we determine that the Saccharomyces cerevisiae Ccr4-Not complex controls ubiquitination of the conserved ribosome-associated heterodimeric EGD (enhancer of Gal4p DNA binding) complex, which consists of the Egd1p and Egd2p subunits in yeast and is named NAC (nascent polypeptide-associated complex) in mammals. We show that the EGD complex subunits are ubiquitinated proteins, whose ubiquitination status is regulated during cell growth. Egd2p has a UBA domain that is not essential for interaction with Egd1p but is required for stability of Egd2p and Egd1p. Ubiquitination of Egd1p requires Not4p. Ubiquitination of Egd2p also requires Not4p, an intact Not4p RING finger domain, and all other subunits of the Ccr4-Not complex tested. In the absence of Not4p, Egd2p mislocalizes to punctuate structures. Finally, the EGD complex can be ubiquitinated in vitro by Not4p and Ubc4p, one of the E2 enzymes with which Not4p can interact. Taken together our results reveal that the EGD ribosome-associated complex is ubiquitinated in a regulated manner, and they show a new role for the Ccr4-Not complex in this ubiquitination. 相似文献
18.
19.
Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex 总被引:1,自引:0,他引:1
Zwartjes CG Jayne S van den Berg DL Timmers HT 《The Journal of biological chemistry》2004,279(12):10848-10854