药物安全性评价中的实验动物福利

开展实验动物福利工作不论对于实验动物自身,还是科学研究都具有重要意义。本文对实践中如何开展实验动物福利工作,以及其中存在的问题进行了初步探讨。     

Safety of Therapeutic Fever Induction in Cancer Patients Using Approved PAMP Drugs

William Coley, between 1895 and 1936, treated hundreds of cancer patients using infusions of fever inducing bacerial extracts. Similar experiments were done by Klyuyeva and co-workers in the 1940ies in Russia using trypanosoma extracts. Many remissions and cures were reported. We have conjectured that pathogen associated molecular pattern substances (PAMP) are the molecular explanation for the beneficial treatments in both groups. We could show that a combination of PAMP can eradicate solid tumours in cancer mice if applied several times. Accordingly, we suggested to combine PAMP containing approved drugs to treat cancer patients using a protocol similar to the old fever induction regimen. In this retrospective phase-1 study we report on the fever induction capacity and safety of applications of bacterial extracts, combinations of bacterial extracts with approved drugs, and combinations of approved drugs in 131 mainly cancer patients. Adverse reactions were those which can be expected during a feverish infection and mild. Over 523 fever inductions, no severe adverse reaction was observed.     

戒毒药物新进展

目前戒毒药物的作用靶点主要包括阿片受体、M受体、a2受体、DA2受体、NMDA受体以及钙离子通道等,与此相对应的戒毒药物均具有较好的疗效,但长期使用会形成心理、躯体依赖及耐受性,停用时出现明显的戒断症状。中药戒毒有较好的发展前途,尤其在控制稽延症状方面优于西药阿片受体类及非阿片受体类。查阅近年来国内外公开发表的有关文章,按戒毒药物的性质分类汇总,并对近年来戒毒药物的研究进展作以综述。     

The Radioprotective Effect of Chlorophyll-Based Drugs

Biophysics - Abstract—This paper summarizes the relevant data on the use of chlorophyll derivatives as radioprotectors, which have been previously presented (partially and without analysis)...