共查询到20条相似文献,搜索用时 7 毫秒
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Pertwee RG 《Molecular neurobiology》2007,36(1):45-59
This review discusses clinical and preclinical evidence that supports the use of cannabinoid receptor agonists for the management
of multiple sclerosis. In addition, it considers preclinical findings that suggest that as well as ameliorating signs and
symptoms of multiple sclerosis, cannabinoid CB1 and/or CB2 receptor activation may suppress some of the pathological changes that give rise to these signs and symptoms. Evidence that
the endocannabinoid system plays a protective role in multiple sclerosis is also discussed as are potential pharmacological
strategies for enhancing such protection in the clinic. 相似文献
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No significant difference was found between 50 consecutive patients with multiple sclerosis and matched controls in respect of previous infection with rubella or measles and chicken-pox, or of previous vaccination and immunizing injections. Significantly more patients had a past history of herpes zoster compared with the controls. 相似文献
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Sreeram V Ramagopalan Colleen Guimond Maria Criscuoli David A Dyment Sarah-Michelle Orton Irene M Yee George C Ebers Dessa Sadovnick 《BMC neurology》2010,10(1):115
Background
There is a strong maternal parent-of-origin effect in determining susceptibility to multiple sclerosis (MS). One hypothesis is that an abnormal intrauterine milieu leading to impaired fetal development could plausibly also result in increased susceptibility to MS. A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly. 相似文献12.
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Attar AM Kharkhaneh A Etemadifar M Keyhanian K Davoudi V Saadatnia M 《Biological trace element research》2012,146(2):150-153
Exposure to heavy metals has been associated to a higher incidence of multiple sclerosis. In this work, we present a possible
relationship between serum mercury levels and development of multiple sclerosis in Isfahan, the third largest city in Iran.
Seventy-four patients affected by multiple sclerosis were retrieved from multiple sclerosis (MS) clinic in Isfahan, Iran.
By matching sex and age, 74 healthy volunteers were chosen as control group. Blood samples were collected and serum mercury
content was determined. Serum mercury level in MS patients was significantly higher than controls (9.6 ± 10.17 vs. 5.7 ± 8.6,
P = 0.037). Concerning all MS patients, serum mercury value was significantly higher than the mercury concentration founded
in control subjects {odd ratio: 2.39 (CI, 1.96–2.94), P = 0.00}. Serum mercury level is higher in MS patients with odd ratio equal to 2.39 compared with healthy individuals. It
may reveal that high mercury levels in serum might help MS development in susceptible individuals. More studies with larger
sample size are needed to confirm this hypothesis. 相似文献
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