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周俐梅 《国外医学:分子生物学分册》1997,19(3):116-119
白细胞介素17是近两年来发现的新的细胞因子;人白细胞介素17由活化的CD4+T细胞产生,并以一种类似于促炎症性的方式作用于其它组织。本着 素17的发现过程及其核酸收白质结构特征。并简明扼要地阐述其已知的生物学活性。 相似文献
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Iida T Ogawa S Tamegai H Adachi Y Saito H Ikegawa S Konishi H Takagi A Matsuzaki T 《Chemistry and physics of lipids》2011,(2):106-112
The 17-propanamide derivatives of diastereomeric Δ14-17α- and 17β-estradiols, the potential candidates of a 17β-hydroxysteroid dehydrogenase (17β-HSD) inhibitor, were synthesized in 11 steps from estrone. The principal reactions employed involved in (1) conversion of estrone to the corresponding Δ14-estrone, (2) Grignard reaction of Δ14-estrone with allylmagnesium bromide followed by regioselective hydroboration of the resulting stereoisomeric 17ξ-allyl-Δ14-17ξ-ols with 9-borabicyclo[3.3.1]nonane (9-BBN), and (3) direct amidation of the 17ξ-O-/17ξ-C-spiro-γ-lactones with NH3 under positive pressure of H2. 相似文献
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Silvana Casati 《Steroids》2009,74(2):250-130
Boldenone is an androgenic anabolic steroid intensively used for growth promoting purposes in animals destined for meat production and as a performance enhancer in athletics. Therefore its use is officially banned either in animals intended for consumption or in humans. Because most anabolic steroids are completely metabolized and usually no parent steroid is excreted, metabolite identification is crucial to detect the illegal use of anabolic steroids either in humans or in livestock. 17α- and 17β-boldenone 17-glucuronides were synthesized, purified and characterized in order to provide suitable standards for the identification and quantification of these metabolites. 相似文献
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报道了香港17种植物新记录:无配膜叶铁角蕨[Hymenasplenium apogamum(N.Murak.&Hatan.)Nakaike]、似薄唇蕨(Leptochilus decurrens Blume)、穿心藤[Amydrium hainanense(H.Li,Y.Shiao&S.L.Tseng)H.Li]、毛背... 相似文献
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《微生物学免疫学进展》2017,(4)
支气管哮喘(bronchial asthma,简称哮喘)是一种常见的慢性气道炎症性疾病,急性发作可危及生命。研究表明,细胞因子白介素17(interleukin-17,IL-17)家族成员在哮喘的发病过程中发挥着重要的作用,其中IL-17A、IL-17F和IL-17E与哮喘密切相关,是目前的研究热点。现对IL-17家族不同成员与哮喘发病机制的相关研究进展作一综述。 相似文献
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结直肠癌是世界范围内的高发癌症,其发病机理尚不明确。大量研究数据表明,基因突变、表观遗传学的改变、饮食习惯以及生活方式等均是结直肠癌发生发展的高危因素。目前,普遍认为慢性炎症在肿瘤的发生发展中起重要作用。白介素17主要由T细胞的亚型Th17细胞分泌产生,能够促进肿瘤相关性炎症,使肿瘤细胞逃避免疫监控。已在胃癌、宫颈癌、食管癌、非小细胞肺癌、肝细胞肝癌、卵巢癌、黑色素瘤、淋巴瘤、乳腺癌、前列腺癌、结直肠癌等多种恶性肿瘤中发现白介素17呈高表达。现有研究表明,白介素17与肠炎和结直肠癌的发生发展密切相关。尽管尚存在争议,多数学者认为白介素17在结直肠癌的发生发展中起促进作用。本文将近年来关于IL-17在结直肠癌的发生发展中的作用以及其与结直肠癌的预后的研究成果进行总结。 相似文献
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成纤维细胞生长因子17(FGF17)是成纤维细胞生长因子(FGF)家族的成员之一,并与FGF8、FGF18组成FGF8亚家族。在胚胎时期FGF17扮演重要角色,对多种组织器官起着重要作用。研究发现,FGF17不仅参与了脑部发育和神经形成,而且参与骨骼、动脉的发育和肿瘤等生物过程。现针对FGF17的特点,及其在胚胎发育、神经系统、癌症等方面的作用进行综述。 相似文献
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17α-ethinylestradiol cometabolism by bacteria degrading estrone, 17β-estradiol and estriol 总被引:2,自引:0,他引:2
Pauwels B Wille K Noppe H De Brabander H Van de Wiele T Verstraete W Boon N 《Biodegradation》2008,19(5):683-693
17alpha-ethinylestradiol (EE2), the active compound of the contraceptive pill, is a recalcitrant estrogen, which is encountered at ng/l levels in wastewater treatment plant (WWTP) effluents and rivers and can cause feminization of aquatic organisms. The aim of this study was to isolate micro-organisms that could remove such low EE2 concentrations. In this study, six bacterial strains were isolated from compost that cometabolize EE2 when metabolizing estrone (E1), 17beta-estradiol (E2) and estriol (E3). The strains belong to the alpha, beta and gamma-Proteobacteria. All six strains metabolize E2 over E1, at mug/l to ng/l concentrations. In 4 days, initial concentrations of 0.5 mug E2/l and 0.6 mug EE2/l were degraded to 1.8 +/- 0.4 ng E2/l and 85 +/- 16 ng EE2/l, respectively. No other metabolites besides E1, E2, E3 or EE2 were detected, suggesting that total degradation and cleavage of the aromatic ring occurred. This is the first study describing that bacteria able to metabolize E2, can subsequently cometabolize EE2 at low mug/l levels. 相似文献
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Bing Han Wei Liu Chun-Lin Zuo Hui Zhu Lu Li Chao Xu Xia-Juan Wang Bing-Li Liu Chun-Ming Pan Ying-Li Lu Wan-Ling Wu Ming-Dao Chen Huai-Dong Song Kai-Xiang Cheng Jie Qiao 《Gene》2013
Mutations of CYP17A1 gene could cause complete or partial, combined or isolated 17α-hydroxylase/17,20-lyase enzyme deficiencies (17OHD). We intended to investigate the CYP17A1 mutation in five unrelated patients and analyze its possible influence on phenotype of an atypical 17OHD patient presented with micropenis, hypertension and intermittent hypokalemia. Steroid hormones were assayed in these patients. A novel missense mutation (c.1169C>G, p. Thr390Arg) located in exon 7 was detected in one of the patients. Homozygous c. 985_987delinsAA, p. Tyr329fs mutation was found in two patients, while compound heterozygous mutations (c. 985_987delinsAA, p. Tyr329fs/c. 932–939 del, p. Val311fs and c. 287G>A, p. Arg96Gln/c. 985_987delinsAA, p. Tyr329fs) were found in two other patients, respectively. Then, steric model analysis of CYP17A1 showed that the novel mutation T390R changed the local structure as well as the electrostatic potential of the nearby beta sheet. Finally, site-directed mutagenesis and in vitro expression were used to analyze the activity of novel mutant CYP17A1. It indicated the T390R mutant retained part of enzyme activity, which was consistent to the clinical features. In conclusion, we identified a novel missense mutation of CYP17A1 gene from a patient with micropenis, hypertension and intermittent hypokalemia, which varied from other four patients. It also expanded our understanding of genotype–phenotype correlation of the disease. 相似文献
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机体的天然免疫系统对于机体免于细菌、病毒或过敏原等外源有害的损伤至关重要。最新的研究表明,在某些条件下,机体天然免疫系统的缺陷甚至与许多自身免疫性疾病、心血管疾病、肥胖以及肿瘤等危害人类健康的慢性疾病的发生发展息息相关。因此,研究清楚人类天然免疫系统的内在运作机理对于认识和治疗各类疾病有着重要的意义。白介素17(interleukin-17,IL-17)家族细胞因子是一类新近被发现的细胞因子类群,越来越多的研究发现该家族成员与天然免疫系统介导的各类反应有着密切的联系。IL-17A(也称IL-17)作为该家族中研究最为深入的成员,被认为参与了多种先天免疫反应。近年来,该家族中一些研究得并不深入的成员也越来越受到人们的关注,这些成员所介导的重要生理和病理功能也正慢慢被揭开。对于该家族细胞因子功能的研究已成为国际免疫学的研究热点。基于此,上海生命科学研究院健康科学研究所的钱友存研究组首次发现该家族中的一个新成员IL-17C的功能受体IL-17RE,并深入阐明了IL-17C-IL-17RE这条信号通路在宿主抵抗肠道病原菌入侵的先天免疫反应中的重要功能和分子机制。这项研究为认识自身的天然免疫系统提供了新的视角,并为感染性疾病的防治提供了重要的理论依据。 相似文献
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目的探讨Th17细胞及相关因子白细胞介素-17(IL-17)在肝移植急性排斥反应中的变化及意义。方法收集2011年1月至2012年12月大连医科大学附属第二医院肝移植手术患者28例,根据移植肝组织穿刺活检病理诊断结果将肝移植的28例患者分为急性排异反应组6例和无排斥反应稳定组22例,15名健康体检者作为对照组。急性排斥组及稳定组在移植术后3 d和7 d,行肝穿刺活检病理检查;同时检测受检者外周血Th17细胞,受检者血清中IL-17水平。结果移植肝穿刺活检病理诊断显示急性排斥组随着移植时间延长,排斥反应逐渐增强。肝组织出现典型的细胞免疫性病理损伤,术后7 d肝脏汇管区、肝实质、小静脉壁、胆管上皮内及小叶间胆管被大量的淋巴细胞及嗜中性粒细胞包绕及浸润,胆管上皮细胞内空泡形成、上皮细胞凋亡。病理改变明显比术后3 d严重;急性排斥组患者术后3 d和7 d外周血Th17细胞比例及血清中IL-17含量较稳定组和对照组均明显增多(P〈0.05),且Th17细胞及IL-17在术后急性排斥期7 d值均明显高于3 d(P〈0.05)。结论 Th17细胞及IL-17在肝移植急性排斥反应的发生、发展中可能起着促进作用,外周血Th17细胞及IL-17的检测有可能成为肝移植急性排斥反应的早期诊断指标。 相似文献
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清栓酶治疗冠心病17例林火成翁南星(福建省厦门市湖里医院厦门361006)本组应用清栓酶治疗冠心病17例,取得了较好的疗效,报告如下。1临床资料1.1对象本组17例冠心病,按世界卫生组织制定的诊断标准,其中男性12例女性5例;干部11例,工人3例,个... 相似文献