Screening of antineoplastic antibiotics using a rapid method of evaluating their cytostatic effect on tumor cells

The study was aimed at development of a rapid method for estimating in vitro cytostatic action of antitumor antibiotics on the basis of intensity of inclusion of labeled precursors into nucleic acids of tumor cells which should be useful in primary screening of antibiotics with potential antitumor activity. The method was applied to substances isolated from 600 cultures of actinomycetes. 35 antibiotics showed antitumor activity; 8 of them were studied in detail. They proved to be novel antibiotics having antitumor activity in animals.     

Synthesis and antineoplastic properties of anthracycline antibiotics modified by a sugar residue]

The present review (for the previous part, see Bioorganicheskaya Khimia. 1990. V. 16. No 11. P. 1445-1464) describes the most important studies in the chemical modifications of the sugar moiety of anthracycline antibiotics and their analogues during last ten years.     

Regulation of prophage induction and lysogenization by phage communication systems

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噬菌体抗体库筛选技术

噬菌体展示技术（Ｐｈａｇｅ Ｄｉｓｐｌａｙ Ｔｅｃｈｎｏｌｏｇｙ）为制备高亲和性抗体提供了有力的工具。噬菌体抗体库的筛选是其中关键的环节,为了提高筛选效率,用包被在固体表面的抗原进行筛选的传统方法不断地被改进,如宿主菌直接洗脱和双层膜筛选系统和抗抗体替代抗原筛选系统。将噬菌体感染宿主菌的过程与筛选过程相关联,产生了选择性感染筛选系统。