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Twenty-five rex(-) mutants of phage lambda have been isolated. Three of the mutants, including one amber mutant, map at three distinct sites within the rex region of the lambda genetic map. The existence of the amber mutant provides further evidence that rex and cI are distinct genes, since it seems to be identical to wild-type lambda in its ability to establish or maintain lysogeny. 相似文献
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Blatny JM Ventura M Rosenhaven EM Risøen PA Lunde M Brüssow H Nes IF 《Molecular genetics and genomics : MGG》2003,269(4):487-498
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Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. 总被引:2,自引:0,他引:2 下载免费PDF全文
P. M. Dunman E. Murphy S. Haney D. Palacios G. Tucker-Kellogg S. Wu E. L. Brown R. J. Zagursky D. Shlaes S. J. Projan 《Journal of bacteriology》2001,183(24):7341-7353
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Bacteria between protists and phages: from antipredation strategies to the evolution of pathogenicity 总被引:2,自引:0,他引:2
Brüssow H 《Molecular microbiology》2007,65(3):583-589
Bacteriophages and protists are major causes of bacterial mortality. Genomics suggests that phages evolved well before eukaryotic protists. Bacteria were thus initially only confronted with phage predators. When protists evolved, bacteria were caught between two types of predators. One successful antigrazing strategy of bacteria was the elaboration of toxins that would kill the grazer. The released cell content would feed bystander bacteria. I suggest here that, to fight grazing protists, bacteria teamed up with those phage predators that concluded at least a temporary truce with them in the form of lysogeny. Lysogeny was perhaps initially a resource management strategy of phages that could not maintain infection chains. Subsequently, lysogeny might have evolved into a bacterium-prophage coalition attacking protists, which became a food source for them. When protists evolved into multicellular animals, the lysogenic bacteria tracked their evolving food source. This hypothesis could explain why a frequent scheme of bacterial pathogenicity is the survival in phagocytes, why a significant fraction of bacterial pathogens have prophage-encoded virulence genes, and why some virulence factors of animal pathogens are active against unicellular eukaryotes. Bacterial pathogenicity might thus be one playing option of the stone-scissor-paper game played between phages-bacteria-protists, with humans getting into the crossfire. 相似文献
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Genes for the establishment and maintenance of lysogeny by the temperate coliphage 186. 总被引:6,自引:3,他引:3 下载免费PDF全文
To identify the genes in coliphage 186 that are required for lysogeny, we isolated clear-plaque mutants. Complementation studies and DNA sequencing identified two genes, the cI gene for the immunity maintenance repressor and the cII gene, which is required only for the establishment of lysogeny. One mutant carried a change in the LexA-binding site controlling expression of the antirepression protein Tum. 相似文献
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