Applying Health Risk Analysis to Assess the Chemical Quality of Water for Recreational Bathing: The Case of Tres Arroyos Creek,Buenos Aires,Argentina

The aim of the study is to assess the probabilistic non-cancer and cancer risks by recreational bathing in Tres Arroyos creeks (southeastern Buenos Aires Province, Argentina). In these waters, hazardous substances (heavy metals, pesticides) have been detected, possibly related to agricultural activities. To assess such risk, USEPA models in aggregated (exposure through accidental oral water intake and dermal contact simultaneously) and cumulative approaches (combined exposure to more than one substance) were applied, performed for bathers of 5, 10, 15, and 20 years old. The results show that chronic bathing in these waters is not harmful at the concentrations and the exposure scenarios considered. Arsenic was the riskiest substance for both non-cancer and cancer effects, affecting mainly the youngest age group, and the accidental water intake during bathing was the most relevant pathway of exposure. On the other hand, the study highlights the key role of the frequency and duration of the bath event. We discuss the results in light of a previous paper of our authorship concluding that the health risk assessment is a valid alternative to analyze recreational water quality, which, unfortunately, is unused by water management agencies in Argentina.     

Uncertainties in age- and gender-based health risk assessment for recreational bathing: Arsenic in Del Azul stream,Argentina

The aim of this study was to assess the risk associated with recreational bathing at Del Azul stream, Argentina, a water course naturally containing Arsenic. It represents a case study on the carcinogenic risk for bathers and on how the risk varies among age groups and genders, analyzing the uncertainties of the model input variables and the risk quantification technique. The risk was probabilistically estimated with the 2D Monte Carlo method considering four age groups (5, 10, 15, and 20 years old) and separate exposure routes: accidental water intake, skin contact, and the two combined. Although in all the studied groups the risk levels were within safety limits, differences in risk values were observed among age groups and genders. Accidental water intake during bathing was the most risky exposure route. The risk decreased with age and it was higher in males than in females, with larger differences between the two older age groups. This could be attributed to the difference in the accidental water intake rate associated with the daily duration of the bathing event, which varied according to age and gender.     

Metal pollution in water environment and the associated human health risk from drinking water: A case study of Sukinda chromite mine,India

Sukinda is one of the most polluted regions of the globe due to chromium pollution. The study sheds light into the heavy metal pollution around the mining area and its effect on the health of the resident populace. The Cr(VI) was in the range of 0.027–2.48 mg/L in surface water and BDL–1.35 mg/L in the groundwater. Multivariate analysis revealed that mining activity was the main source of TCr, Cr(VI), and Zn in the surface water that warrants attention. Heavy metal evaluation index showed high levels of Fe, Mn, and Cr in groundwater that can pose serious threat to the exposed population. Cancer and non-cancer risk of Cr(VI) was higher than other metals in groundwater. The results revealed that the total cancer risk was 1.21E-03 and 1.05E-03 in adults and children, respectively, which exceeded the USEPA acceptable cancer health risk. High health risk was observed through oral intake of water, while both cancer and non-cancer risks were negligible through dermal contact. This study strongly advocates proper periodic assessment of drinking as well as surface water in the area and regulation to restrict the use of contaminated water for daily use.     

Health Risks of Metals in Soil,Water, and Major Food Crops in Hamedan Province,Iran

Food, drinking water, soil, and air are the main routes of exposure to trace metals, thus the assessment of the risks posed to humans by these elements is important. Wheat, potatoes, and maize are very important parts of the Iranian diet. The objectives of this study were to estimate the non-carcinogenic and carcinogenic health risks of Hg, Pb, Cd, Cr, Se, As, and Ni to adults and children via soil, water, and major food crops consumed in Hamedan Province, northwest Iran, using the total non-cancer hazard quotient (THQ) and cancer risk assessment estimates. Total non-cancer hazard of Ni and Hg, were greater than 1, and total cancer risk of As and Pb was greater than 1 × 10^?6. Food consumption was identified as the major route of human exposure to metals, and consuming foodstuff threatens the health of the studied population. In Hamedan Province, consumption of wheat is the main source of intake of metals from foodstuff for adults, and in children, the soil ingestion route is also important.     

Non-Carcinogenic Risk Assessment of Heavy Metals and Fluoride in Some Water Wells in the Al-Baha Region,Saudi Arabia

On a global scale, pathogenic contamination of drinking water poses the most significant health risk to humans. However, significant risks to human health may also result from exposure to nonpathogenic, toxic contaminants that are often ubiquitous in waters. The purpose of this study is to determine the levels of heavy metal and fluoride contaminants in water wells used in the Al-Baha region, Saudi Arabia, to evaluate if the levels of metals will have non-carcinogenic effects. Samples were collected from private wells in the area and were analyzed for chemical contamination using approved methods of collection and analysis. Chromium, manganese, zinc, iron, and fluoride were detected in all samples, and were selected for toxicological evaluation. Exposure through ingestion and dermal contact were the scenarios proposed in this study. Chronic daily intakes (CDIs) were estimated for both routes and then compared with health guideline values. The non-cancer risk estimations show that manganese, chromium, and zinc individually have oral Hazard Quotient (HQ) values less than a value of one. Iron and fluoride were found to have oral HQ values greater than 1 in some samples. Also, on considering the additive effect of the contaminants we found that some samples have Hazard Index (HI) values greater than 1, which indicates that there is a concern for chronic non-cancer adverse health effects in case of oral and dermal routes of exposure to water from these wells.     

Environmental Risk of Pesticides: Applying the DelAzulPestRisk Model to Freshwaters of an Agricultural Area of Argentina

DelAzulPestRisk is a risk-based chemical ranking model based on human and local biota toxicities that estimates the integrated risk of pesticides in water from their extensive (concentration, risk) and intensive (persistence, bioaccumulation) chemical properties. The model is built on two modules: human health risk factor (estimated based on the probabilistic cancer and non-cancer health risk by using U.S. Environmental Protection Agency models applied to a bathing exposure scenario) and biota health risk factor (quantified on the basis of the probabilistic toxicity exposure ratio –PEC/PNEC– for three local representatives of water biota multiplied by an amplification factor supported by the persistence and bioaccumulation potential). The model was applied to shallow creeks of Tres Arroyos County, Argentina, which flow across wheat and soybean agricultural lands, and in whose waters were detected many organochlorine pesticides (α, γ, y, δ-HCH, aldrin, heptachlor, γ-chlordane, endosulfan, endosulfan sulphate, dieldrin, and DDD). Dieldrin, aldrin, and heptachlor generated the worst potential effects—due mainly to the cancer and non-cancer dermal health risk—although this was not a significant environmental threat. DelAzulPestRisk is a screening assessment tool for water management purposes that become useful in countries lacking efficient water quality control systems.     

Potential Health Risk of Reused Creosote-Treated Old Railway Ties at Recreational Sites in Korea

Old creosote-treated railway ties reused at recreational sites in Korea are potential hazards, due to the presence of harmful substances in creosote, such as polycyclic aromatic hydrocarbons (PAHs). In such sites, PAHs in ties can be leached or emitted, and human exposure might then occur. In this study, the concentrations of 16 PAHs in soil, air, and tie surfaces in old creosote-treated railway ties reused in recreational sites were investigated, and the potential health risk of the ties was evaluated through two exposure scenarios: a recreational scenario (ingestion of and dermal contact with soil and inhalation of soil particles) and a playground scenario (ingestion after contact and dermal contact with ties). For the recreational scenario, the health risks of PAHs were safe; however, for the playground scenario, the carcinogenic risk of ingestion after contact, and dermal contact with benz(a)anthracene and benzo(a)pyrene on the tie surfaces, exceeded the acceptable risk level (10^–6). For the carcinogenic risks of ingestion after contact with ties, the probabilities of cancer development were 8 and 5 in one million people for benz(a)anthracene and benzo(a)pyrene, respectively. The carcinogenic risks for dermal contact with ties were 2.4 × 10^–6 and 1.4 × 10^–6 for benz(a)anthracene and benzo(a)pyrene, respectively.     

Assessing Children's Exposures and Risks to Drinking Water Contaminants: A Manganese Case Study

Background: Compared to adults, children maybe more highly exposed to toxic substances in drinking water because they consume more water per unit of body weight. The U.S. Environmental Protection Agency (USEPA) has developed new guidance for selecting age groups and age-specific exposure factors for assessing children's exposures and risks to environmental contaminants. Research Aim: To demonstrate the application and importance of applying age-specific drinking water intake rates, health reference values, and exposure scenarios when assessing drinking water exposures because these approaches illustrate the potential for greater potential for adverse health effects among children. Methods: manganese, an essential nutrient and neurotoxicant, was selected as a case study and chemical of potential concern for children's health. A screening-level risk assessment was performed using age-specific drinking water intake rates and manganese concentrations from U.S. public drinking water systems. Results: When age-specific drinking water intake rates are used to calculate dose, formula-fed infants receive the highest dose of manganese from drinking water compared to all other age groups. Estimated hazard quotients suggest adverse health effects are possible. Use of USEPA's standardized childhood age groups and childhood exposure factors significantly improves the understanding of childhood exposure and risks.     

Determination and risk assessment of toxic metals in lipsticks from Europe and China

BackgroundThe presence of toxic toxic metals in lipstick can pose a health risk to many consumers of this type of cosmetics, especially for women. Thus, the aim of this study was to assess consequences attributed to dermal and oral exposure to toxic metals in lipsticks manufactured in China and Europe as determined by non-cancer and cancer risks assessment models from SCCS and USEPA, respectively.MethodThe treatment of the samples was carried out by calcination using muffle furnaces and the determination of Al, Cd and Pb were determined by inductively coupled plasma optical emission spectrometry (ICP-OES).ConcentrationsThe concentration of Cd and Pb in the study samples does not exceed the limits stablished for the FDA (00,228 mg kg⁻¹·day⁻¹ for Cd and 000,343 mg kg⁻¹·day⁻¹ for Pb, respectively) but they do not comply with the Regulation of the European Parliament, which prohibits the presence of these two metals in cosmetics. Neither European Union nor United States have established maximum levels for Al in cosmetics.ConclusionsThe cancer risk assessment of Cd and Pb metals resulted in a total cancer risk less than 1. The results of non-cancer oral risk assessment for Pb had a MoS result of 88 for China and 62 for Europe, suggesting that Pb poses a risk for the human health, especially in samples manufactured in Europe.     

Quantification of Changes in Chemical Pesticide Human Health Risk Following the Introduction of Bt Cotton and Herbicide-tolerant Soybean: A Case Study

Human health risks associated with changes in synthetic chemical pesticide use following the introduction of genetically modified crops are quantified in this article. Bacillus thuringiensis ( Bt ) cotton and herbicide-tolerant (HT) soybean, two genetically modified crops, were chosen as the focus for this study based on their global popularity. An innovative multimedia total exposure model, CalTOX, was used to calculate the health risks for two target populations, before and after the introduction of Bt cotton and HT soybean. Major results include the quantification of incremental lifetime cancer risk based on a time-weighted average exposure, and the quantification of hazard ratios for non-cancer effects based on the maximum exposure rate value, both computed over the exposure duration. Results show that human health risks are not intuitively and necessarily reduced with the reduction of pesticide use. For example, more trifluralin was used after the introduction of HT soybeans in Iowa and Minnesota, leading to higher risks. Moreover, the general population may have larger exposures to pesticides when compared with the population living in areas where pesticides are actually applied. This may occur because exposure to pesticides is not only dependent on geographical distance from the contaminated area, but also strongly dependent on other factors, such as the characteristic travel distance and environmental persistence.     

Human health risk assessment of arsenic in groundwater aquifers of Lahore,Pakistan

The present study was conducted to estimate As concentration in groundwater and resulting human health risk in terms of chronic daily intake, hazard quotient (HQ), hazard index (HI), and carcinogenic risk (CR) both for oral and dermal exposure to As. Groundwater samples (n = 100) were collected from ten different towns of Lahore District (Pakistan). Arsenic concentration ranged from 2 to 111 µg L^?1 in groundwater samples of the study area, which was significantly greater than the safe limit of As (10 µg L^?1) in drinking water set by the World Health Organization. Health risk assessment of As showed that HQ (0.1–11) for oral exposure and HI (0.1–11) values also exceeded the typical toxic risk index value of 1. 9.75 × E-05–4.59 × E-03 and 5.89 × E-07–2.77 × E-05 for oral and dermal As exposure, respectively. Both CR and cancer index (CIs) values were higher than United States Environmental Protection Agency limit (10^?6), suggesting that people are at high risk of As-induced carcinogenicity from oral and dermal exposure to As in drinking water. It was concluded that As contamination of groundwater causes carcinogenic and noncarcinogenic health effects to the people; therefore, urgent management and remedial actions are required to protect people from As poisoning.     

Risk of otitis externa after swimming in recreational fresh water lakes containing Pseudomonas aeruginosa.

OBJECTIVE--To determine whether an outbreak of otitis externa was due to bathing in recreational fresh water lakes and to establish whether the outbreak was caused by Pseudomonas aeruginosa in the water. DESIGN--Matched case-control study. SETTING--The Achterhoek area, the Netherlands. SUBJECTS--98 cases with otitis externa and 149 controls matched for age, sex, and place of residence. MAIN OUTCOME MEASURES--Odds ratios for type of swimming water and frequency of swimming; presence of P aeruginosa in ear swabs and fresh water lakes. RESULTS--Otitis externa was strongly associated with swimming in recreational fresh water lakes in the previous two weeks (odds ratio 15.5 (95% confidence interval) 4.9 to 49.2) compared with non-swimming). The risk increased with the number of days of swimming, and subjects with recurrent ear disease had a greatly increased risk. The lakes met the Dutch bathing water standards and those set by the European Commission for faecal pollution in the summer of 1994, but P aeruginosa was isolated from all of them, as well as from the ear swabs of 78 (83%) of the cases and 3 (4%) of the controls. CONCLUSIONS--Even when current bathing water standards are met, swimming can be associated with a substantial risk of otitis externa because of exposure to P aeruginosa. People with recurrent ear disease should take special care when swimming in waters containing P aeruginosa.     

USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties

Purpose

The aim of this paper is to provide science-based consensus and guidance for health effects modelling in comparative assessments based on human exposure and toxicity. This aim is achieved by (a) describing the USEtox? exposure and toxicity models representing consensus and recommended modelling practice, (b) identifying key mechanisms influencing human exposure and toxicity effects of chemical emissions, (c) extending substance coverage.

Methods

The methods section of this paper contains a detailed documentation of both the human exposure and toxic effects models of USEtox?, to determine impacts on human health per kilogram substance emitted in different compartments. These are considered as scientific consensus and therefore recommended practice for comparative toxic impact assessment. The framework of the exposure model is described in details including the modelling of each exposure pathway considered (i.e. inhalation through air, ingestion through (a) drinking water, (b) agricultural produce, (c) meat and milk, and (d) fish). The calculation of human health effect factors for cancer and non-cancer effects via ingestion and inhalation exposure respectively is described. This section also includes discussions regarding parameterisation and estimation of input data needed, including route-to-route and acute-to-chronic extrapolations.

Results and discussion

For most chemicals in USEtox?, inhalation, above-ground agricultural produce, and fish are the important exposure pathways with key driving factors being the compartment and place of emission, partitioning, degradation, bioaccumulation and bioconcentration, and dietary habits of the population. For inhalation, the population density is the key factor driving the intake, thus the importance to differentiate emissions in urban areas, except for very persistent and mobile chemicals that are taken in by the global population independently from their place of emission. The analysis of carcinogenic potency (TD₅₀) when volatile chemicals are administrated to rats and mice by both inhalation and an oral route suggests that results by one route can reasonably be used to represent another route. However, we first identify and mark as interim chemicals for which observed tumours are directly related to a given exposure route (e.g. for nasal or lung, or gastrointestinal cancers) or for which absorbed fraction by inhalation and by oral route differ greatly.

Conclusions

A documentation of the human exposure and toxicity models of USEtox? is provided, and key factors driving the human health characterisation factor are identified. Approaches are proposed to derive human toxic effect factors and expand the number of chemicals in USEtox?, primarily by extrapolating from an oral route to exposure in air (and optionally acute-to-chronic). Some exposure pathways (e.g. indoor inhalation, pesticide residues, dermal exposure) will be included in a later stage. USEtox? is applicable in various comparative toxicity impact assessments and not limited to LCA.     

Exposure to Crystalline Silica Inhalation Among Construction Workers: A Probabilistic Risk Analysis

Crystalline silica and its presence in dust generated during various construction activities may pose a health hazard to construction workers. In this article, the occupational exposure to crystalline silica and the related long-term health (cancer and non-cancer) risks among construction workers from five different trades (activities) were evaluated using a probabilistic approach. The predicted 95th percentile of the excess lifetime cancer risk and hazard quotients for exposure to crystalline silica ranged from 4.5 × 10^?5 to 1.2 × 10^?4, and 15 to 37, respectively. The efficiency of the state-of-the-art technologies to reduce silica inhalation at construction sites are evaluated in the context of reduction in long-term health risks to the construction workers. The use of engineering controls and personal protective equipments to reduce the exposure to crystalline silica reduced the hazard quotient and excess lifetime cancer risk approximately by 65% and 78%, respectively. The sensitivity analyses showed that the exposure concentration of crystalline silica was the most significant parameter in both cancer and non-cancer risk estimates for the construction workers. The breathing rate, the exposure factor, and the daily shift hours also significantly contribute to the cancer and non-cancer risk estimates for the construction workers.     

Is Cancer in Israeli Professional Divers Exposed to Polluted Waters an Occupational Disease?

Because there is some contamination of practically every body of water, risk analysis is important to determine diving exposure standards to pollutants, including requirements for protective equipment. In the following study we attempt to determine the increased risk of cancer in Israeli Naval divers exposed to pollutants in the Kishon River system. We calculated two risks, one using maximally recorded levels of pollutants outside the diving areas (worst-case scenario), and the other using maximally recorded levels in the actual diving areas. For both calculations we used conservative assumptions for exposure (2500 exposure hours with 50% of body covered with sediment), and a synergistic risk model. We considered all chemicals that were carcinogenic by inhalation also to be carcinogenic by oral and dermal absorption. The relative risk was 1.13 for the worst-case scenario, and 1.004 for exposures in actual diving areas. We conclude that it is unlikely that exposure to the polluted Kishon River waters can cause a detectable increase in cancer risk in Israeli Navy divers. This study has implications for professional divers exposed to polluted waters.     

Monitoring of arsenic in drinking water of high schools and assessment of carcinogenic health risk in Multan,Pakistan

Abstract

This study was performed to measure arsenic (As) contents in groundwater/drinking water of high schools and its effects on human health. Chronic daily intake, hazardous quotient (HQ), carcinogenic risk (CR), hazardous index (HI), and carcinogenic indices (CI) for oral and dermal exposure to arsenic were calculated. Samples were taken from high schools in four tehsils of Multan. As contents ranged from 3.25 to 184?µg/l and 99% samples exceeded World Health Organization safe limit (10?µg/l). HQ for Multan city (1.70) and for Multan Saddar (1.38) exceeded USEPA permissible toxic risk value (1.0). CR in four tehsils for oral (0.0001–0.0003) and dermal exposure (0.0000049–0.000011) exceeded USEPA limit (10^?6). HI for tehsil Multan city (1.75) and Multan Saddar (1.42) exceeded the limit (1.0). CI for four tehsils ranged from 0.00022 to 0.0008 exceeding USEPA limit (10^?6) indicating high chronic and carcinogenic health risk to exposed population. Results indicated that groundwater of district Multan is not fit for human consumption due to excessive arsenic contamination. It invites attention of water supplying agency and educational authorities to take steps for provision of arsenic free safe drinking water to students and local area peoples.     

Health Risks of Heavy Metals through Consumption of Greenhouse Vegetables Grown in Central Iran

Elevated heavy metal (HM) concentrations in vegetables may pose serious health risks to humans. There is limited information on health risks associated with HM contaminants in greenhouse vegetables. The objective of this study was to estimate the health risks of Pb, Cd, Ni, and Cr via consumption of greenhouse cucumbers and bell peppers produced in Iran using the total non-cancer hazard quotient (THQ) and cancer risk assessment estimates. Cadmium, Pb, Ni, and Cr concentrations in the vegetables varied from < 0.02 to 0.05, 0.19 to 0.64, 0.16 to 0.20 and 0.07 to 0.13 μg g^?1, respectively. Individual metal THQ values indicate the relative absence of non-cancer health effects associated with intake of a single metal through consumption of either cucumbers or bell peppers. The THQ for all population groups via consumption of greenhouse cucumbers and bell peppers was smaller than 1.0, which shows low possibility of any obvious risk. The result showed that Cd is the major risk contributor for the consumers. The cancer risk assessment for Pb for Qom adult populations groups via consumption of cucumbers and bell peppers was greater than 1 × 10^?6. High Pb and Cd concentration in the greenhouse vegetables is an important concern that has to be considered.     

Microbial risk assessment: don't forget the children

Quantitative microbial risk assessment is a rapidly developing field with a purpose to quantify risks of infection, disease and mortality from the environmental exposure of pathogens. It is currently being applied to the development of standards for drinking water, wastewater re-use and foods. A growing body of evidence indicates that the greatest risk of infection for enteric pathogens is for persons less than 19 years of age. Children are more likely to become ill from consumption of contaminated drinking water and recreational activities. These increased risks may be because immunological, neurological and digestive systems are still developing. In addition, children are more environmentally exposed to pathogens. For some enteric pathogens children may be the greatest at risk population.     

Health risk assessment due to exposure of arsenic contamination in drinking water of district Shiekhupura,Punjab, Pakistan

Abstract

The present study was conducted to assess the magnitude and health impacts of As in drinking water. Drinking water samples (n?=?60) were collected from twenty different sites of Shiekhupura District (Pakistan). Health risk assessment through average daily dose (ADD), hazard indices (HI), hazard quotient (HQ), carcinogenic risk (CR), and cancer indices (CI) for dermal and oral exposure were determined. Results revealed that As concentration ranged from 2 to 900?µg?L^?1 in water samples, which was significantly greater than the safe limit of As (10?µg?L^?1) in water. Health risk assessment of As showed that ADD (1.07E?02–9.85E?04), HQ (1.06E+01–9.85E+00), and CR (1.60E?02–9.85E?04) for oral exposure and ADD (1.03E?05–9.69E?06), HQ (1.19E?02–7.96E?03), and CR (1.11E?05–8.98E?05) for dermal exposure which were exceeded the toxic risk index value. Comparison of the two exposure pathways indicated that the oral exposure is much higher risk than the dermal contact. Both values of HI and CI were greater than WHO limit. It is concluded that residents of study area are at higher risk of As induced diseases and carcinogenicity.     

Analysis of Worldwide Naphthalene Surface Soil Regulatory Guidance Values

Many environmental regulatory jurisdictions worldwide specify the maximum soil contamination mass burdens that may occur without prompting a regulatory response. For residential surface soils, these regulatory guidance values (RGVs) are generally based on human (often child) health risks from inhalation, ingestion, and dermal exposure to contamination. RGVs have been promulgated for more than 1,200 soil contaminants. Of these, naphthalene is the most frequently regulated contaminant. The 234 known naphthalene RGVs range from a minimum of 0.0289 mg/kg to a maximum of 16,000 mg/kg and span 5.7 orders of magnitude. Analysis illustrates that, although there are small non-random clusters of values, and there may be statistically significant differences between the values used in the U.S. and elsewhere around the world, the overall distribution of numbers strongly resembles (r = 0.9953) that of a log-normal random variable. Results of Monte Carlo uncertainty analysis applied to the U.S. Environmental Protection Agency risk model are presented to approximate the range of the naphthalene RGV span that can be attributed to uncertainty in cancer or non-cancer risk formulations. Uncertainty in the cancer risk formulation could account for approximately 41% of the RGVs. Uncertainty in the non-cancer risk formulation could account for a different 22% of the RGVs, but the cancer risk model generally yields the binding (lowest) value. The implications of these widely variable RGVs for health risk and remediation costs are discussed and methods of reducing variability are suggested.