A Historical Loop of One Hundred Years: Similarities Between 19th Century and Contemporary Dream Research

Contemporary cognitive and neuropsychological approaches to dreaming show striking methodological and conceptual similarities with the scientific dream literature of the last century. The use of introspective dream reports and the emphasis on dream phenomenology are characteristic of both periods but were bannished during the first half of this century, the former by behaviorism, the latter by psychoanalysis. Three main common axioms of 19th century and contemporary dream research are described: (a) dream experience results from cognitive syntheses realized in the absence of external constraints; (b) dream narrative or dream coherency involves mental associative mechanisms; (c) dream bizarreness emerges from a cerebral state characterized by functional dissociation. According to these three axioms, the observation of dream phenomena reveals that distinct cognitive processes might function in a partly autonomous, automatic, and dissociated way, making dreaming a unique model of these cognitive processes.     

Le psychothérapeute psychanalyste « à <Emphasis Type="Italic">l’école de la phénoménologie</Emphasis> »

The mixing of psychoanalysis and phenomenology fosters the development of psychotherapy, psychoanalysis drawing on phenomenology to offer a method of studying and understanding the human being; this creates a genuine form of “anthropology”. Phenomenology’s contributions to psychoanalysis revolve around the three notions of épochè, the understanding of others and transference. On the one hand, épochè (a suspension of natural states of mind, obviousness and knowledge; an eidetic reduction; and an opening to the world and others) ensures better comprehension (“to take with yourself”) of others and their existential projects. On the other hand, épochè prevents falling into the transference and countertransference traps and sets the distance necessary for the hermeneutic act, that is, the interpretation of what is no longer there, what is absent, yet said and indicated by language in psychoanalytic therapy. Through its humanist, anthropological perspective and its overall understanding of the human being, phenomenology leads the way to rethinking clinical psychotherapy to create a more unified discipline.     

Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell.

Most poliovirus (PV) strains, including PV PV-1/Mahoney, are unable to cause paralysis in mice. Determinants for restriction of PV-1/Mahoney in mice have been identified by manipulating PV-1 cDNA and located on the viral capsid protein VP1. These determinants consist of a highly exposed amino acid sequence on the capsid surface corresponding to the B-C loop (M. Murray, J. Bradley, X. Yang, E. Wimmer, E. Moss, and V. Racaniello, Science 241:213-215, 1988; A. Martin, C. Wychowski, T. Couderc, R. Crainic, J. Hogle, and M. Girard, EMBO J. 7:2839-2847, 1988) and of residues belonging to the N-terminal sequence located on the inner surface of the protein shell (E. Moss and V. Racaniello, EMBO J. 10:1067-1074, 1991). Using an in vivo approach, we isolated two mouse-neurovirulent PV-1 mutants in the mouse central nervous system after a single passage of PV-1/Mahoney inoculated by the intracerebral route. Both mutants were subjected to two additional passages in mice, plaque purified, and subsequently characterized. The two cloned mutants, Mah-NK13 and Mah-NL32, retained phenotypic characteristics of the parental PV-1/Mahoney, including epitope map, heat lability, and temperature sensitivity. Mah-NK13 exhibited slightly smaller plaques than did the parental virus. The nucleotide sequences of the mutant genomes were determined, and mutations were identified. Mutations were independently introduced into the parental PV-1/Mahoney genome by single-site mutagenesis. Mutated PV-1/Mahoney viruses were then tested for their neurovirulence in mice. A single amino acid substitution in the capsid proteins VP1 (Thr-22-->Ile) and VP2 (Ser-31-->Thr) identified in the Mah-NK13 and Mah-NL32 genomes, respectively, conferred the mouse-virulent phenotype to the mouse-avirulent PV-1/Mahoney. Ile-22 in VP1 was responsible for the small-plaque phenotype of Mah-NK13. Both mutations arose during the first passage in the mouse central nervous system. We thus identified a new mouse adaptation determinant on capsid protein VP1, and we showed that at least one other capsid protein, VP2, could also express a mouse adaptation determinant. Both determinants are located in the inside of the three-dimensional structure of the viral capsid. They may be involved in the early steps of mouse nerve cell infection subsequent to receptor attachment.     

ANALYTIC GROUP PSYCHOTHERAPY—For Wives and Husbands

The practice of group psychotherapy has its roots in Freudian dynamics and concepts, and varies from play group psychotherapy to analytic group psychotherapy, using the dynamics of transference, catharsis, interpretation, insight, ego building, reality, and sublimation.This presentation is based on the experience of the author with about 40 women patients formed in groups at a sanatorium. The majority were neurotic, psychoneurotic or manic-depressive. Several were psychotic. Some of the patients were treated in groups that included their husbands, after discharge from the sanatorium.Analytic group psychotherapy is a concept of an attenuated mobile and uncensored societal setting, where persons who have failed in the larger and harsher social reality may again attempt resocialization in a permissive, friendly, and protected environment. It is not to be considered the poor man''s makeshift for individual psychoanalysis. Group dynamics facilitate the regression and catharsis necessary to produce insight and ego strength, leading to more rapid recovery.Husband and wife participation in the same group led to a more tolerant acceptance by the husband of the concept of mental ailment, and empathy for the spouse.The role of the psychiatrist in group psychotherapy is very similar to that in individual psychoanalysis. He represents the reality to the patient and the group. He is objective but permissive, and not passive. Therapeutic goals are the same as in individual therapy, and may focus on the resolution of pre-oedipal conflicts or on situational maladjustments.     

Review and Meta‐analysis of Pharmacotherapy for Binge‐eating Disorder

This study evaluated available controlled treatment studies to determine utility of pharmacotherapy for binge‐eating disorder (BED). The authors identified randomized placebo‐controlled trials testing pharmacotherapy‐only treatments and controlled trials testing pharmacotherapy with psychotherapy treatments. Meta‐analysis was performed on placebo‐controlled trials with data for attrition, remission, and weight loss. Qualitative review was performed on remaining controlled treatment literature. A total of 33 studies were considered of which 14 studies with a total of 1,279 patients were included in the meta‐analysis of pharmacotherapy‐only treatment and 8 studies with a total of 683 patients were included in the qualitative review of pharmacotherapy combined with psychotherapy interventions. No evidence suggested significant differences between medication and placebo for attrition. Evidence suggested that pharmacological treatments have a clinically significant advantage over placebo for achieving short‐term remission from binge eating (48.7% vs. 28.5%) and for weight loss, although weight losses are not substantial. No data exist to allow evaluation of longer‐term effects of pharmacotherapy‐only treatment for BED. Combining medications with psychotherapy interventions failed to significantly enhance binge outcomes, although specific medications (orlistat, topiramate) enhanced weight losses achieved with cognitive behavioral therapy and behavioral weight loss. In summary, BED patients can be advised that certain pharmacotherapies may enhance likelihood of stopping binge eating short term, but that longer‐term effects are unknown. Although some weight loss may occur, it is unlikely to be substantial with available medications. Combining medications with cognitive or behavioral treatments is unlikely to enhance binge outcomes, but specific medications (orlistat, topiramate) may enhance weight losses, albeit modestly.     

Analytic group psychotherapy; for wives and husbands

The practice of group psychotherapy has its roots in Freudian dynamics and concepts, and varies from play group psychotherapy to analytic group psychotherapy, using the dynamics of transference, catharsis, interpretation, insight, ego building, reality, and sublimation.This presentation is based on the experience of the author with about 40 women patients formed in groups at a sanatorium. The majority were neurotic, psychoneurotic or manic-depressive. Several were psychotic. Some of the patients were treated in groups that included their husbands, after discharge from the sanatorium. Analytic group psychotherapy is a concept of an attenuated mobile and uncensored societal setting, where persons who have failed in the larger and harsher social reality may again attempt resocialization in a permissive, friendly, and protected environment. It is not to be considered the poor man's makeshift for individual psychoanalysis. Group dynamics facilitate the regression and catharsis necessary to produce insight and ego strength, leading to more rapid recovery. Husband and wife participation in the same group led to a more tolerant acceptance by the husband of the concept of mental ailment, and empathy for the spouse. The role of the psychiatrist in group psychotherapy is very similar to that in individual psychoanalysis. He represents the reality to the patient and the group. He is objective but permissive, and not passive. Therapeutic goals are the same as in individual therapy, and may focus on the resolution of pre-oedipal conflicts or on situational maladjustments.     

Where Empathy in Psychotherapy Originated: C. Rogers,His Psychoanalytic Predecessors and Followers

This article presents a historical-psychological analysis of how the concept of empathy appeared and became established in psychotherapy. It examines in detail the early psychoanalytic approaches of S. Ferenczi and O. Rank and their possible influence on C. Rogers’s laying the groundwork for the role of empathy. For the first time in Russian psychology, the article illuminates certain aspects of the biographies of Rogers and H. Kohut as the founders of new schools in psychotherapy, of which empathy is the paramount feature. Kohut’s self-psychology is analyzed from the standpoint of his postulation of the “threefold” status of empathy as a method of psychology, a tool of the analyst, and the subject of a universal requirement of development. It briefly considers the development of the views of Rogers and Kohut in the latest “experiential” schools in the person-centered approach and intersubjective psychoanalysis.     

Is there a role for culture in human behavioral ecology?

Most research in human behavioral ecology has been acultural, which raises the question of how best to incorporate the concept of culture into this approach. A necessary step in this direction is to pare the culture concept down to its ideational elements, excluding behavior and its material products (Durham 1991; Geertz 1973; Keesing 1974). The cultural and reproductive success hypothesis, though empirically successful (Irons 1993), is not a model for all of culture because of widespread discrepancies between behavior and culture to which it does not call attention. Cultural transmission models are also weakened by such discrepancies, but, more importantly, such models are most relevant to phenomena different from those central to human behavioral ecology. A better way to incorporate culture into human behavioral ecology is to see it as the context of human action and as a tool people use in social manipulation. The study of signal systems is a key to an understanding of social manipulation and to the incorporation of culture into human behavioral ecology. Examples of the manipulation of culture for reproductive benefit include Yanomamö kin term manipulation (Chagnon 1988), incest rules (Thornhill 1990, 1991), and the derogation of sexual competitors (Buss and Dedden 1990). The human behavioral ecological study of social manipulation in cultural contexts needs to be expanded. Two phenomena that might shed light on such manipulation are the Rashomon effect and the audience effect.     

Classification of Unconscious Phenomena and The Category of Activity

For many years, the subject of consciousness has been beyond the pale of American academic psychology. Every history of psychology tells us that Wundt's structuralism sought to study the "contents of consciousness" and that the failure of this effort resulted in Watsonian behaviorism (at least, within the American context). In recent years, however, there has been a reawakening of interest among cognitive psychologists in the phenomenon of conscious awareness.     

Modern approaches to human cognitive activity enhancement

Recent literature on human cognitive activity enhancement is reviewed and summarized. Two classes of pharmacological approaches are picked out, i.e. modern aspects of traditional substance utilization and application of specially developed drugs. Among non-pharmacological approaches a number of psychological, physiological, behavioral and biophysical methods to improve human cognition, memory and learning are analyzed. The most attention is paid to non-drug approaches that utilize bioelectric processes of the individual including characteristics of its brain electrical activity--electroencephalogram (EEG) to enhance different aspects of cognitive functioning. Some promising lines of these investigations are delineated.     

Molecular Genetic Analysis of Revertants from a Poliovirus Mutant That Is Specifically Adapted to the Mouse Spinal Cord

SA virus, a mutant of the Mahoney strain of type 1 poliovirus (PV1/Mahoney), replicates specifically in the spinal cords of mice and causes paralysis, although the PV1/Mahoney strain does not show any mouse neurovirulence (Q. Jia, S. Ohka, K. Iwasaki, K. Tohyama, and A. Nomoto, J. Virol. 73:6041-6047, 1999). The key mutation site for the mouse neurovirulence of SA was mapped to nucleotide (nt) 928 of the genome (A to G), resulting in the amino acid substitution of Met for Ile at residue 62 within the capsid protein VP4 (VP4062). A small-plaque phenotype of SA appears to be indicative of its mouse-neurovirulent phenotype. To identify additional amino acid residues involved in the host range determination of PV, a total of 14 large-plaque (LP) variants were isolated from a single point mutant, Mah/I4062M, that showed the SA phenotype. All the LP variants no longer showed any mouse neurovirulence when delivered via an intraspinal inoculation route. Of these, 11 isolates had a back mutation at nt 928 (G to A) that restored the nucleotide of the PV1/Mahoney type. The reversions of the remaining three isolates (LP8, LP9, and LP14) were mediated by a second site mutation. Molecular genetic analysis involving recombinants between Mah/I4062M and the LP variants revealed that the mere substitution of an amino acid residue at position 107 in VP1 (Val to Leu) (LP9), position 33 in VP2 (Val to Ile) (LP14), or position 231 in VP3 (Ile to Thr) (LP8) was sufficient to restore the PV1/Mahoney phenotype. These amino acid residues are located either on the surface or inside of the virus particle. Our results indicate that the mouse neurovirulence of PV is determined by the virion surface structure, which is formed by all four capsid proteins.     

The concept of neurasthenia and its treatment in Japan

The term neurasthenia, which had been widely used in Japan before the Second World War, came to be replaced by the term neurosis thereafter. With this change in terminology, there seems to have been a shift in the popular ideas of minor psychiatric disorders towards a more psychological view. Unlike in the West where psychoanalysis was a major contributing factor, in Japan it was Shoma Morita who contributed to this change by questioning the somatic basis of conditions then diagnosed as neurasthenia and by developing the conceptshinkeishitsu in the early 1920's, rejecting the concept of neurasthenia. In his theory, the development of shinkeishitsu symptoms is explained in terms of certain psychic dispositions and as a vicious cycle of sensation and attention; he formulated a psychological treatment, Morita therapy, which has been very effective for that condition. With the advent of modernization in this country, doubts have been raised whether this form of psychotherapy with continue to be acceptable to modern Japanese. However, in reality many neurotic patients are still being treated with Morita therapy, although analytically oriented psychotherapy is coming to be practiced more and more in recent years. The indigenous psychotherapies represented by Morita therapy and Naikan therapy have deep-seated roots in Buddhist tradition: its values and ideas have been redefined and reformulated into forms of therapy acceptable to modern Japanese.This paper was translated by Ryu Suzuki.     

Binge Eating Disorder: Current Knowledge and Future Directions

Binge eating disorder (BED) is a newly characterized eating disorder that encompasses individuals who have severe distress and dysfunction due to binge eating, but who do not regularly engage in inappropriate compensatory behaviors. While relatively uncommon in the general community, BED becomes more prevalent with increasing severity of obesity. BED is associated with early onset of obesity, frequent weight cycling, body shape disparagement, and psychiatric disorders. These associations occur independent of the degree of obesity. Although many individuals with BED have good short-term weight loss regardless of treatment modality, as a group they may be prone to greater attrition during weight-loss treatment and more rapid regain of lost weight. Current treatments geared toward binge eating behaviors include antidepressant medications, cognitive behavioral psychotherapy, and interpersonal psychotherapy; however, these treatments have little efficacy in promoting weight loss, and only modest success in long-term reduction of binge eating. As a significant proportion of obese individuals entering weight-loss treatment and research programs are likely to meet criteria for BED, those conducting clinical research should be aware of this distinct subgroup and determine the contribution of BED to outcome measures. (OBESITY RESEARCH 1993; 1:306–324)     

多巴胺信号系统在衰老引起的行为和认知能力退化中的作用

衰老是生物体随时间推移各项生理功能逐渐发生改变的自然现象。动物的衰老伴随着行为和认知能力的降低,因此研究动物行为和认知功能退化的分子神经机制对于提高老年群体的生活质量具有重要意义。近年来,随着正电子发射断层扫描技术和功能性核磁共振脑成像技术在神经生物学上的广泛运用,越来越多证据表明多巴胺系统功能在衰老过程中显著降低,并且这是人类和动物行为和认知功能退化的重要原因。本文将概述自然衰老过程中多巴胺信号系统功能变化及机制和其在动物行为和认知退化中的作用等方面研究进展。     

The effects of depression,anxiety and sleep disturbances on cognitive impairment in patients with chronic obstructive pulmonary disease

The purpose of this study was to investigate the effects of depression, anxiety and sleep disturbances on cognitive functions in chronic obstructive pulmonary disease (COPD) patients. In this prospective case-control study, demographic data, smoking history, depression, anxiety, sleep quality and cognitive status of 48 COPD patients and 36 healthy volunteers aged 40–90 years were recorded. The Beck depression inventory (BDI), the Beck anxiety inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI) were used to assess depression, anxiety and sleep quality, respectively in COPD patients. Cognitive performance was studied by the mini-mental state examination. The mean age of patients with COPD was 65.3 ± 9.4 years, and disease duration was 9.6 ± 7.8 years. Male sex ratio, smoking, BDI score, BAI score, total PSQI score, sleep latency, sleep duration, average use of sleep aids and sleep disturbances in patients with COPD were significantly higher than the control group (p < 0.05). When cognitive impairment was compared by age, FVC, FEV, FEV/FVC, PEF values and smoking, no statistically significant relationship was found (p > 0.05). A statistically significant relationship was established between cognitive impairment and severity of disease, presence of anxiety, presence of depression and sleep quality. In our study, we found that sleep disorders, depression and anxiety comorbid with COPD increased cognitive impairment as well as the severity of disease. We believe that this finding is important in terms of reducing the risk of cognitive impairment, preventing misdiagnosis and treatment of the aforementioned comorbid diseases.     

The Treatment of Pathological Tendencies and Obsessional Conditions by Diversion Psychotherapeutic Methods

As is known, today's psychotherapy may be divided into two categories: lower-order psychotherapy, in the form of hypnosis or suggestion in the waking state, and higher-order psychotherapy, in the form of treatment by Déjérine's exercise,¹ rational therapy or Dubois's persuasion therapy,² Freud's psychoanalysis,³ and treatment by Martsinovsky's methods.⁴     

Toward a cognitive ecology

The emergence of cognitive psychology as the dominant approach to understanding human behaviors and actions acknowledges the importance of internal mental operations in generating specific behavioral responses to sets of external stimuli. Traditional behaviorist interpretations that rely primarily on external inputs as the precursors of action have been largely replaced by cognitive approaches. The main intent of this article is to outline the major areas that require exploration if we wish to apply fully the principles and insight of cognitive science to behavioral ecology.     

Explaining consumer choice: coming to terms with intentionality

Any attempt to understand the nature of behaviorism as a philosophy of science, to depict the essence of its distinctive explanatory system, or to delimit the scope of its capacity to explicate behavior, requires an appreciation of how its practitioners use language. Three behaviorist theories that are especially relevant to the explanation of economic behavior - radical behaviorism, teleological behaviorism, and picoeconomics - provide a necessary array of theoretical perspectives in that each contributes uniquely to understanding consumer choice. Despite the differences that separate them at a methodological level, and the internecine disputes in which their adherents sometimes address one another, these three perspectives play complementary roles in the depiction of everyday consumer behavior. Moreover, this combination of behavior theories owes much to the way in which each has responded to the challenge of intentional explanation. In order to demonstrate this, the paper proposes a framework of analysis which portrays the essential differences between intentional explanation and the extensional approach towards which many behaviorists have striven, and argues that while radical behaviorism scrupulously avoids intentional terms, teleological behaviorism and picoeconomics have in differing ways come to terms with the necessity of combining a behaviorist perspective with the explanatory value of intentional terminology. This continuum of explanations is applied to recent findings of consumer behavior analysis on consumer choice in natural environments.