Prospective,Blinded Exploratory Evaluation of the PlayWisely Program in Children with Autism Spectrum Disorder

The purpose of the study was to explore a low-cost intervention that targets an increasingly common developmental disorder. The study was a blinded, exploratory evaluation of the PlayWisely program on autism symptoms and essential learning foundation skills (attention, recognition, and memory skills) in children with a diagnosis of autism, autism spectrum disorder (ASD), pervasive developmental disorder – not otherwise specified (PDD-NOS), and Asperger syndrome (AS). Eighteen children, 1 to 10 years of age, were evaluated using the Childhood Autism Rating Scale, Second Edition (CARS2); the PlayWisely Interactive Test of Attention, Recognition, and Memory Skills; Autism Treatment Evaluation Checklist (ATEC), and the Modified Checklist for Autism in Toddlers (M-CHAT). There were significant treatment effects for the PlayWisely measure on the Yellow Sets that examine recognition; Purple Sets that examine brain region agility and early memory skills; Blue Sets that examine phonemic awareness and recognition; and for the Total Sets, with a similar trend toward improvement in the Green Sets that examine perception and Red Sets that examine attention. No other measures reached statistical significance. The results suggest that PlayWisely can improve recognition, brain region agility, phonemic awareness, letter recognition, and early memory skills in ASD. It was observed by the parents, coaches, and study investigators that the children who were less than 3 years of age showed improvements in autism symptoms; however, the group was too small to reach statistical significance. Future studies are needed to see if this intervention can mitigate autism symptoms in very young children with ASD.     

Eye Tracking Young Children with Autism

The rise of accessible commercial eye-tracking systems has fueled a rapid increase in their use in psychological and psychiatric research. By providing a direct, detailed and objective measure of gaze behavior, eye-tracking has become a valuable tool for examining abnormal perceptual strategies in clinical populations and has been used to identify disorder-specific characteristics¹, promote early identification², and inform treatment³. In particular, investigators of autism spectrum disorders (ASD) have benefited from integrating eye-tracking into their research paradigms^4-7. Eye-tracking has largely been used in these studies to reveal mechanisms underlying impaired task performance⁸ and abnormal brain functioning⁹, particularly during the processing of social information^1,10-11. While older children and adults with ASD comprise the preponderance of research in this area, eye-tracking may be especially useful for studying young children with the disorder as it offers a non-invasive tool for assessing and quantifying early-emerging developmental abnormalities^2,12-13. Implementing eye-tracking with young children with ASD, however, is associated with a number of unique challenges, including issues with compliant behavior resulting from specific task demands and disorder-related psychosocial considerations. In this protocol, we detail methodological considerations for optimizing research design, data acquisition and psychometric analysis while eye-tracking young children with ASD. The provided recommendations are also designed to be more broadly applicable for eye-tracking children with other developmental disabilities. By offering guidelines for best practices in these areas based upon lessons derived from our own work, we hope to help other investigators make sound research design and analysis choices while avoiding common pitfalls that can compromise data acquisition while eye-tracking young children with ASD or other developmental difficulties.     

Sensory Features as Diagnostic Criteria for Autism: Sensory Features in Autism

In this study, we examined the frequency of sensory-related issues as reported by parents in a large sample of school-age adolescents and adults with autism/autism spectrum disorder (ASD) [1] as compared to a group of individuals receiving similar clinical evaluations for developmental/behavioral difficulties but whose final diagnoses were not on the autism spectrum. In no comparison were the features examined predictive of autism or autism spectrum in comparison to the non-ASD sample. Only failure to respond to noises had sensitivity above .75 in the comparison of the broader autism spectrum group, but specificity was poor. While sensory issues are relatively common in autism/ASD, they are also frequent in other disorders. These results question the rationale for including sensory items as a diagnostic criterion for autism.     

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

In addition to impairments in social communication and the presence of restricted interests and repetitive behaviors, deficits in sensory processing are now recognized as a core symptom in autism spectrum disorder (ASD). Our ability to perceive and interact with the external world is rooted in sensory processing. For example, listening to a conversation entails processing the auditory cues coming from the speaker (speech content, prosody, syntax) as well as the associated visual information (facial expressions, gestures). Collectively, the “integration” of these multisensory (i.e., combined audiovisual) pieces of information results in better comprehension. Such multisensory integration has been shown to be strongly dependent upon the temporal relationship of the paired stimuli. Thus, stimuli that occur in close temporal proximity are highly likely to result in behavioral and perceptual benefits – gains believed to be reflective of the perceptual system''s judgment of the likelihood that these two stimuli came from the same source. Changes in this temporal integration are expected to strongly alter perceptual processes, and are likely to diminish the ability to accurately perceive and interact with our world. Here, a battery of tasks designed to characterize various aspects of sensory and multisensory temporal processing in children with ASD is described. In addition to its utility in autism, this battery has great potential for characterizing changes in sensory function in other clinical populations, as well as being used to examine changes in these processes across the lifespan.     

The Role of Therapy Dogs in Speed and Accuracy to Complete Motor Skills Tasks for Preschool Children

ABSTRACT

The purpose of this study was to determine whether the presence of a therapy dog would affect the performance of a set of gross motor skills tasks for a mixed group of language-impaired and typical preschool children. The 14 children in the group were between four and six years old (four female and ten male); the two dogs were Miniature Poodles. The design was a two-way mixed model factorial, where a series of 10 gross motor skills tasks (e.g., long jump, high jump—labeled Type of Task) performed by the children served as one variable, and the presence or absence of the therapy dog (labeled Dog Presence) served as the other variable. In the dog-present conditions, the dog either performed the task immediately prior to, or at the same time as, the child. Time to complete each task and the accuracy of task performance as determined by a rating scale were determined from a review of experiment videotapes. The main effect of Dog Presence was significant (F_(1,36) = 7.471, p < 0.05, R² = 0.17). As predicted, the children completed the tasks faster when the dog was present (M = 10.88 s,SD = 9.84) than when the dog was absent (M = 13.86 s,SD = 12.64), but this effect was not present in the ratings data. This indicates that the presence of a therapy dog served as an effective motivator for the children, who performed faster, but without compromising accuracy, in all tasks but one. The interaction between dog presence and type of task was also significant (F_(9,71) = 3.67, p < 0.05, R² = 0.32) in the ratings data, indicating that the presence of the dog increased performance accuracy in some types of tasks, while decreasing it in others. Based on these results and the strong connection between motor skills and language development, the authors recommend a role for therapy dogs in speech and language development programs for preschool children.     

Different Visual Preference Patterns in Response to Simple and Complex Dynamic Social Stimuli in Preschool-Aged Children with Autism Spectrum Disorders

Eye-tracking studies in young children with autism spectrum disorder (ASD) have shown a visual attention preference for geometric patterns when viewing paired dynamic social images (DSIs) and dynamic geometric images (DGIs). In the present study, eye-tracking of two different paired presentations of DSIs and DGIs was monitored in a group of 13 children aged 4 to 6 years with ASD and 20 chronologically age-matched typically developing children (TDC). The results indicated that compared with the control group, children with ASD attended significantly less to DSIs showing two or more children playing than to similar DSIs showing a single child. Visual attention preference in 4- to 6-year-old children with ASDs, therefore, appears to be modulated by the type of visual stimuli.     

Increased Risk of Autism Development in Children Whose Mothers Experienced Birth Complications or Received Labor and Delivery Drugs

Autism spectrum disorder (ASD) is a perplexing and pervasive developmental disorder characterized by social difficulties, communicative deficits, and repetitive behavior. The increased rate of ASD diagnosis has raised questions concerning the genetic and environmental factors contributing to the development of this disorder; meanwhile, the cause of ASD remains unknown. This study surveyed mothers of ASD and non-ASD children to determine possible effects of labor and delivery (L&D) drugs on the development of ASD. The survey was administered to mothers; however, the results were analyzed by child, as the study focused on the development of autism. Furthermore, an independent ASD dataset from the Southwest Autism Research and Resource Center was analyzed and compared. Indeed, L&D drugs are associated with ASD (p = .039). Moreover, the Southwest Autism Research and Resource Center dataset shows that the labor induction drug, Pitocin, is significantly associated with ASD (p = .004). We also observed a synergistic effect between administrations of L&D drugs and experiencing a birth complication, in which both obstetrics factors occurring together increased the likelihood of the fetus developing ASD later in life (p = .0003). The present study shows the possible effects of L&D drugs, such as Pitocin labor-inducing and analgesic drugs, on children and ASD.     

Novel Treatment for Lead Exposure in Children with Autism

The pathogenesis of some cardiovascular diseases (CVDs) has been altered with changes in the balance of certain trace and toxic elements. The aim of the present study was to assess the role of zinc (Zn) and cadmium (Cd) in smoker and nonsmoker male CVD patients (n?=?457) of two age groups (31–45) and (46–60). The both elements were determined in biological samples (scalp hair, blood, and urine) of CVD patients and healthy referents for comparison purpose. The concentrations of Zn and Cd were measured by atomic absorption spectrophotometer prior to microwave-assisted acid digestion. It was observed that the mean values of Cd were significantly higher in the biological samples of smokers CVD as compared to nonsmoker CVD patients, while the level of Zn was lower in both smoker and nonsmoker patients. The concentrations of Zn in whole blood and scalp hair samples were lower in CVD patients as compared to referents (p?>?0.001). Results showed significant changes of levels of Cd and Zn in blood and scalp hair samples of CVD patients when compared with healthy referents, while reverse in the case of urine samples. It was observed that low Zn levels were associated with both smoker and nonsmoker CVD patients, while increased cadmium accumulation was observed in smoker patients as compared to nonsmoker patients (p?>?0.025).     

Owner Attachment and Problem Behaviors Related to Relinquishment and Training Techniques of Dogs

Problematic behaviors are a significant reason for relinquishment, and relinquished dogs are more likely to have problem behaviors. This study utilized standardized surveys of owners (companion animal guardians) relinquishing their dogs to shelters and dog owners visiting vaccination clinics. “Relinquishing” and “continuing” owners were asked questions in the following categories: demographic information, training methods and tools, frequencies in which their dogs engaged in problematic behaviors, and attachment to their dogs. “Relinquishers” were also asked to provide their reasons for relinquishment. The results of 129 surveys (80 relinquishing and 49 continuing) showed that relinquishers scored lower on companion animal attachment than continuing owners. Pit bull-type dogs were represented more in the relinquishing group. Relinquished dogs were no less likely to have attended training classes than continuing dogs. In both groups, owners who used punishment-based collars reported less satisfaction with their dogs' overall and leash-walking behaviors. Pit bull-type dogs were reported to be no less well behaved compared with all other breeds combined. Sixty-five percent of relinquishers reported some behavioral reason for relinquishment. Forty-eight percent of relinquishers indicated that at least 1 problem behavior was a strong influence on their decision to relinquish.     

Ability of the Public to Recognize Dogs Considered to Be Dangerous under the Dangerous Dogs Act in the United Kingdom

Canine aggression came into the public eye in the United Kingdom in the late 1980s prompting enactment of the UK Dangerous Dogs Act , which prohibits four breeds or “types” of dogs. The act faced strong opposition surrounding correct identification of prohibited dogs. A questionnaire was distributed to the public via an online platform, especially targetting those who have worked with dogs. The questionnaire assessed respondents’ abilities to identify the four banned types of dogs from other breeds and their capability to identify Pit Bull Terrier types from other similar dog types. Identification of both banned breeds, F(1, 20) = 57.746, p < .001, and bull breeds, F(1, 20) = 9.293, p = .006, was significantly lower than identification of other breeds. Recognition of Pit Bull Terrier types from similar types of dogs was generally poor, although people in a dog-related profession, as opposed to those in other professions, could correctly distinguish more pit bull-type dogs (U = 46,164.0, n₁ = 187, n₂ = 575, p = .003). Findings suggest public understanding of dangerous dogs is poor, and it may impact societal perceptions of dogs more widely.     

Toward Innovative,Cost-Effective,and Systemic Solutions to Improve Outcomes and Well-Being of Military Families Affected by Autism Spectrum Disorder

The burdens faced by military families who have a child with autism are unique. The usual challenges of securing diagnostic, treatment, and educational services are compounded by life circumstances that include the anxieties of war, frequent relocation and separation, and a demand structure that emphasizes mission readiness and service. Recently established military autism-specific health care benefits set the stage for community-viable and cost-effective solutions that can achieve better outcomes for children and greater well-being for families. Here we argue for implementation of evidence-based solutions focused on reducing age of diagnosis and improving access to early intervention, as well as establishment of a tiered menu of services, individualized to the child and family, that fit with the military ethos and system of health care. Absence of this new model of care could compromise the utility and sustainability of the autism-specific benefit.     

HPLC法测定犬体内罗格列酮药物动力学参数

目的-研究马来酸罗格列酮在犬体内的药动学特点。方法-以乙腈固相提取, HPLC法测定马来酸罗格列酮的血浆药物浓度; 以3P97软件计算磷酸罗格列酮药动学参数。结果与结论-马来酸罗格列酮在犬体内呈现1级吸收权重为1的一室模型规律; 其主要的药动学参数为 V (c) 约 0 4231 mg/kg/ (μg·ml-1), T1/2(ke)约107 6 min, CL约0 0027 mg·kg-1·min/ ( g·ml-1)。     

A Comprehensive Survey of Current and Former College Students with Autism Spectrum Disorders

Background: There is a paucity of research concerning individuals with autism spectrum disorders (ASD) pursuing higher education.Method: This study sought to augment this gap in the literature by surveying individuals with ASD who are currently college students or who have previously attended college.Results: Thirty-five individuals completed an online survey. These individuals reported receiving extensive academic supports that enabled their academic success. Their reported difficulties in the social and emotional domains received less support. In addition, not all areas of campus life were supportive, as study abroad and career service offices were reported to not understand individuals with ASD.Conclusions: Overall, the results of this survey indicate the importance of self-advocacy and the need for institutions of higher education to provide comprehensive supports for individuals with ASD in the academic, social, and emotional domains in order to effectively integrate this group into the campus environment.     

Communication Patterns Within a Group of Shelter Dogs and Implications for Their Welfare

Keeping shelter dogs in groups provides them with a more socially and physically enriched environment, but eventually it may cause them stress. Understanding dogs' communication could help shelter staff recognize and prevent undesirable communicative patterns and encourage desirable ones. Therefore, the objective of this study was to determine communication patterns in a group of dogs in a shelter. The observed dogs were engaged in different classes of dyadic and group interactions. Certain dogs were frequently initiators of dyadic interactions, and different dogs were the recipients. The predominant form of dyadic interactions was a neutral one, and aggressive behavior was rarely observed. The tendency of certain dogs to interact continuously may represent a nuisance for less social individuals. All of the dogs participated in 3 defined classes of group interactions. At the group level, the dogs frequently interact vocally or olfactorily. A major welfare problem may be very vocal dogs because their vocalizations are noisy and broadcast far-reaching signals. The frequency of some group interactions was reduced by the amount of time the dogs had in the shelter.     

Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an unknown molecular pathogenesis. A recent molecular focus has been the mutated neuroligin 3, neuroligin 3(R451C), in gain-of-function studies and for its role in induced impairment of synaptic function, but endoplasmic reticulum (ER) stress induced by mutated molecules also deserves investigation. We previously found two missense mutations, H246N and Y251S, in the gene-encoding synaptic cell adhesion molecule-1 (CADM1) in ASD patients, including cleavage of the mutated CADM1 and its intracellular accumulation. In this study, we found that the mutated CADM1 showed slightly reduced homophilic interactions in vitro but that most of its interactions persist. The mutated CADM1 also showed morphological abnormalities, including shorter dendrites, and impaired synaptogenesis in neurons. Wild-type CADM1 was partly localized to the ER of C2C5 cells, whereas mutated CADM1 mainly accumulated in the ER despite different sensitivities toward 4-phenyl butyric acid with chemical chaperone activity and rapamycin with promotion activity for degradation of the aggregated protein. Modeling analysis suggested a direct relationship between the mutations and the conformation alteration. Both mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis.     

Carrying, Sharing, and Hand Preference in Tufted Capuchins (Cebus apella)

We examined the relationship among carrying, food-sharing, and hand preference in tufted capuchins (Cebus apella). The rationale was to evaluate further the use of Cebus as an alternative primate model to Pan for behavior relevant to early hominid evolution. We first examined bipedalism and food-sharing within an established social group, and then examined the direction and strength of hand preference for food carrying in an expanded sample. Several aspects of capuchin behavior warrant discussion. First, bipedal carrying and food-sharing occurred more frequently when we provided bulky foods than when we provided smaller foods. Second, food-sharing was characterized by passive tolerance, rather than active giving, between subjects. Third, subjects shared food primarily with immatures and followed a pattern of reciprocal exchange. Finally, we found no evidence for population-level hand preference for carrying. We posit that an array of behavioral similarities among Cebus, Pan, and Homo evolved through convergent processes, and in this regard capuchins can be seen as an alternative primate model to chimpanzees for the evolution of early hominid behavior.     

Dogs and Owners Resemble Each Other in the Eye Region

ABSTRACT

Although several studies have shown perceived facial resemblance between photos of purebred dogs and their owners, none of these studies has clarified which part of the face is critical for such an impression to arise. The series of experiments presented here identified the critical feature underlying the perceived dog–owner facial resemblance. In total, 502 Japanese undergraduate students participated in the study. Two sets of 20 dog–owner photo pairs had been color-printed on a test sheet: the dogs varied in breed and the owners were Japanese males and females in their twenties to sixtieswho were unknown to the participants. One set comprised real pairs, while the other was a fake set (i. e., each dog was paired with another dog's owner). As in a previous study, the majority of participants (from two-thirds to three-quarters) reported that the former set was more similar than the latter. This was also the case even when the mouth regions of the owners' faces were masked by black bars. However, masking the eye regions of either dogs or owners reduced the choice performance to a chance level of around 50%. Furthermore, choice performance was equally good and above the chance level, regardless of whether the entire faces were shown or only the eye regions of the dogs and owners were visible. These results strongly suggest that dogs and owners resemble each other in the eye region. This finding also ruled out the possibility that any nonphysiognomic features (e. g., owners' hairstyles and people's stereotypical concepts about dog ownership) or similarity of obesity are determinate for the perceived dog–owner resemblance.