Angiology of the brain of the baboon Papio ursinus, the vervet monkey Cercopithecus pygerithrus, and the bushbaby Galago senegalensis

The investigation was undertaken to compare the blood supply and venous drainage of the brain of the baboon P. ursinus, the vervet monkey C. pygerithrus, and the bushbaby G. senegalensis with that of man, because these animals are extensively used as research models. The blood supply of the three primates was found to be similar in each case. Like man they have a complete circulus arteriosus; but they have a single anterior cerebral artery, whereas man has paired anterior cerebral arteries. The arterial supply to the cerebellum in the primates is similar to that in man, the main difference being a "common inferior cerebellar artery" which bifurcates to form the anterior inferior cerebellar and posterior inferior cerebellar arteries. In man, these arteries arise separately from the basilar artery and vertebral arteries, respectively. The dural venous drainage was also found to be similar in these primates but was far more extensive than in man. The primates have additional sinuses--the more important of these being the "basisphenoid sinus" and the petrosquamous sinus. The former drains the basilar sinus and is itself drained via the vertebral venous plexus and internal jugular vein. The latter drains via the petrosquamous foramen into the retromandibular vein. The petrosquamous sinus has a rostral extension which drains through the foramen ovale and two lateral and medial connecting sinuses which drain the cavernous and basilar sinuses, respectively. These sinuses are not found in man.     

Lecture 13. Language and Consciousness

We have cursed "psychology" because we were living in a "characterless" era … That era has passed, and so we again have need of the entire soul, the whole of what is life, the whole man … Back to the soul, not just to man, but to the "whole man"—with a spirit, with body and soul, with all that is part of life—thrice over.     

Organization of the sympathetic innervation in liver tissue from monkey and man

Summary The sympathetic innervation of the liver of monkey and man has been investigated in a combined fluorescence histochemical, chemical and electron microscopical study. By means of the Falck-Hillarp fluorescence method a dense network of monoamine-containing nerve fibers was visualized in liver tissue of monkey and man. The nerve fibers ran in close contact to both hepatocytes and blood vessels. Chemical quantitations showed high concentrations of noradrenaline in both human and monkey liver. Microspectrofluorometry of the intraneuronal monoamine resulted in spectra characteristic of a catecholamine. For the electron microscopical study the dopamine analogue, 5-hydroxydopamine, was used to label the catecholamine terminals in both human and monkey liver. The nerve profiles, identified as catecholamine-containing, were demonstrated in a perivascular location and in close contact to hepatocytes. No synaptic membrane specializations were present between nerve fibers and hepatocytes. The general ultramorphology and intralobular distribution pattern of nerves in the liver of monkey and man were similar. The present results prove the existence of a sympathetic innervation of hepatocytes and blood vessels in the liver of man and monkey.     

滇西北丽江盆地中更新世哺乳动物化石新材料

本文简记了滇西北丽江盆地的中更新世哺乳动物化石新材料.化石产自东元桥村南东元桥组的河流相灰黄、灰色砂层和砂砾层中,计有8属10种,即Megantereon sp.、Equussp.、Dicerorhinus sp.、Cervavitus ultimus、cf.Axis rugosus、cf.Axis yunnanensis、Rusayunnanensis、Rusa sp.、Muntiacus sp.、Bos sp..动物群中的一些属种出现于元谋盆地“元谋人”动物群中,表现出两地动物群的相似性,这为“元谋人” 时代的确定可能提供新资料.     

A case of relapsing cutaneous larva migrans transmitted by a cheetah (Acinonyx jubatus)

A case of relapsing "creeping eruption" connected with parasites of the cheetah is reported in the man. The parasitological examination, carried out in two cheetahs liable of this syndrome, has shown two different helmintic species: Ancylostoma caninum and Ancylostoma tubaeforme.     

A family of hypervariable minisatellites detected by means of a sequence derived from phage M 13

A new family of "hypervariable minisatellites" has been identified in the genome of man and of a variety of animal species using as a probe a DNA segment isolated from the M 13 bacteriophage. This finding provides a new series of hyperpolymorphic genetic markers and renders the "DNA-fingerprinting" methodology available to every molecular biology laboratory.     

A Probabilistic Model of Perception

The development of electronic computers has made it possible to transfer to them a number of the "intellectual" functions of man. At present such machines are being employed to model broader and broader regions of man's psychological activity. One of the most important problems in this connection is the building of "perceptive machines," such as reading machines, "the printing phonograph" and so forth. Perceptive machines are a necessary element in the development of automatic equipment to operate in complicated environments.     

A comparative analysis of the impact on biota and man in the 30 km zone of the Chernobyl NPP

A methodological approach is described for a comparative assessment of ionizing radiation effects on man and biota, based on the use of indices of radiation impact--ratios of actual exposure doses to environmental objects (including humans) and critical ones. As such doses, standards limiting radiation exposure and doses at which phenotypical effects were absent after the Chernobyl accident were employed, respectively for man and biota. For the test site chosen within the 30 km ChNPP zone (region of the Borshchovka settlement), dose burdens to reference biota species and the population (with and without evacuation) and the corresponding radiation impact indices were calculated. For the long term period after the accident radiation safety standards for man are shown to ensure radiation safety for biota as well. At the same time in the early period after the accident the emergency regulations do not guarantee adequate protection of nature, some species of which can be subject to irradiation more than man, even if countermeasures like evacuation are not applied. A conclusion has been made on the necessity of a more detailed and comprehensive analysis of situations when the anthropocentric principle "if radiation standards protect man then biota are also adequately protected" is violated.     

Thoughts on the cultural evolution of man. Developmental imprinting and transgenerational effect

The biological evolution of man stopped since it has been conveyed to the objects, created by man. This paper introduces the concept of "conveyed evolution". Being part of the cultural evolution, the conveyed evolution is a continuation of the biological one. There are several similarities between the laws of biological and conveyed evolution, albeit the differences are important as well. Some laws of the conveyed evolution are described here. The conveyed evolution has man-made repair mechanisms (medicine, protection of environment) which defend man from harm. Man's fragility limits the progress of conveyed evolution. However, artificial compounds or environmental pollutants which are provoked by the conveyed evolution induce chemical (hormonal) imprinting in the developmental critical periods, which is transmitted to the progeny generations (transgenerational effect). This could cause evolutionary alterations without mutation.     

重要生物恐怖病原及其医学防护对策

生物恐怖问题由来已久,但直到美国“9.11”事件后的炭疽芽孢袭击才引起人们广泛关注。生物恐怖已成为21世纪全人类的威胁,防范生物恐怖病原袭击已成为各国政府的当务之急。本文主要介绍了对生物恐怖的定义、生物恐怖病原种类和致病特征,以及医学防护对策。     

Radiation protection of the environment: anthropocentric and eco-centric principles

The second half of the XX century was dominated in the field of radiation protection of the environment by the anthropocentric concept stated by the International Commission on Radiological Protection (ICRP). According to this concept "if man is adequately protected by radiological standards then biota are also adequately protected". At the end of the XX--beginning of the XXI centuries in the area of area of radiation protection of nature an ecocentric strategy is beginning to develop where emphasis has swung to the protection of biota in their environment. Inadequacy of ICRP's anthroposentric concept is reported. Issues are discussed such as ecological dosimetry, nonequidosal irradiation of man and biota, criteria for estimating radiation induced changes in biota and man, as well as the need to harmonize permissible exposure doses to man and biota. An urgent need is stressed to develop a single (synthetic) concept of radiation protection which simultaneously ensures protection of human health and biota well-being in their environment. This concept is to be based on the recognition of the integrity of socio-natural ecosystems where man and biota are considered as a unity.     

The Completion of Temporary Connections Through Speech

One of the lines of Soviet research that has commanded the interest of American researchers for many years is the attempt to extend the principles of conditioning to account for human verbal behavior. Pavlov's distinction between the first and the second signal systems (the first applying to animals and man, the latter only to man) has been the starting point for Soviet analysis of this problem. Briefly put, the first signal system applies to the conditioning of environmental stimuli that initially signal nothing in particular, but come, through the process of conditioning, to signal another event (as when a tone comes to signal food); the second signal system refers to stimuli that are themselves already signals of other events and come to act as "signals of signals" via conditioning processes. Human language is the vehicle of the second signal system.     

Environmental history as an anthropologic topic. Contribution to "chemical anthropology"

Human population history is firmly connected with temporal and regional changes of the environment. Whether natural or anthropogene, alteration of environmental features lead to changes of human life-style and to the development of adaptive strategies. The demand of resources for his subsistence has led man to diverse impacts on his environment since ever. Thus, environmental history is a scientific topic for anthropologists. The research potential of trace element studies of excavated human skeletons for the reconstruction of natural and socio-cultural environments as well as for distribution patterns of hazardous substances is outlined for the European Middle Ages. The scientific value of unravelling past man/environment-interrelationships for both the historical and applied sciences and the place of any "chemical anthropology" within this context is discussed.     

The evolution of the mitochondrial D-loop region and the origin of modern man.

The origin of modern man is a highly debated issue that has recently been tackled by using mitochondrial DNA sequences. The limited genetic variability of human mtDNA has been explained in terms of a recent common genetic ancestry, thus implying that all modern-population mtDNAs originated from a single woman who lived in Africa less than 0.2 Mya. This divergence time is based on both the estimation of the rate of mtDNA change and its calibration date. Because different estimates of the rate of mtDNA evolution can completely change the scenario of the origin of modern man, we have reanalyzed the available mitochondrial sequence data by using an improved version of the statistical model, the "Markov clock," devised in our laboratory. Our analysis supports the African origin of modern man, but we found that the ancestral female from which all extant human mtDNAs originated lived in a time span of 0.3-0.8 Mya. Pushing back the date of the deepest root of the human implies that the earliest divergence would have been in the Homo erectus population.     

Critics of perfection

"In praise of imperfection" means to Rita Levi-Montalcini, Nobel prize for Medicine (1986), praise of man, as an unique being mixed of good and evil, whose greatness and dynamism is in its imperfection. Levi-Montalcini confesses her tendency to exclude herself, avoiding social contacts (a tendency she also improperly attributes to J. Watson). However, how can this be reconciled with a view such as that of Kundera: "Existence is not what has happened... Once again, existing means 'being in the world"'?     

The ultrastructure and function of human skeletomuscular tissue]

The electron microscopic study of the intact somatic muscle of man has established that skeletal muscular fibres have a well developed lysosome apparatus. This apparatus is localized near nuclei under the sarcolemma and is represented by 3 types of lysosomes: primary lysosomes, secondary lysosomes (phage lysosomes, digestive vacuoles) and residual bodies. These three morphological types of lysosomes reflect different stages of the functional activity of these organelles. The role of the lysosome apparatus in the process of intracellular digestion and self-renewal is shown. The presence of a peculiar "digestive center" of the muscle fibre has been established which is located in the perinuclear zone.     

Phylo- and ontogenetic development of the nucleus of the brachium of the inferior colliculus]

In recent neuromorphological investigations and in studying the passage, as an addition to nuclei of the auditory system so called "parabrachial area" was subjected to a special comparative cytoarchitectonic investigation and terminological definition, since the term "parabrachial nucleus" has already been reserved in neuromorphology to designate other brain formations. The investigation has demonstrated that the term "nucleus of the inferior quadrigemina brachium" is more suitable to the form studied. This nucleus has been stated to penetrate deeply into the inferior tuberculum corpori quadrigemina, unlike the previous notion according to which it was believed to be situated between the internal geniculate body and the inferior tuberculum corpori quadrigemina. Therefore, two parts have been distinguished in the formation in question, inherent to all the mammalia studied, including the man. One of them--extracollicular portion, though it has not been previously studied from the view of comparative architectonics, nevertheless, it has been described in literature. The other--intracollicular portion is described for the first time in the work. In spite of a close topographic-anatomical proximity with the inferior corpora quadrigemina, the intracollicular portion of the nucleus cannot be a derivative from the latter.     

Acatalasemia in the mouse and other species

Genetic control of the level of blood catalase activity was first demonstrated in 1927. At present, such control has been demonstrated or suggested for nine different species, including man, the most studied. The development of an acatalasemic strain of mice has permitted a wide variety of experimental approaches, including most of those used in humans. Among those approaches which cannot readily be applied to man but have been used in acatalasemic mice are investigations of sensitivity to radiation lethality, mechanism of awareness to radiation, possible use as a model for replacement therapy for inborn errors of metabolism, and catalase in tissues other than erythrocytes. These are described, together with genetic, immunological, and other studies comparable to similar work on acatalasemic humans.This paper was presented at a symposium entitled Genetic Control of Mammalian Metabolism held at The Jackson Laboratory, Bar Harbor, Maine, June 30–July 2, 1969. The symposium was supported in part by an allocation from NIH General Research Support Grant FR 05545 from the Division of Research Resources to The Jackson Laboratory.Work supported by the United States Atomic Energy Commission.     

Extensor muscles of the thigh of crab-eating monkeys (Macaca fascicularis)

On the basis of 44 hindlimbs of 11 male and 11 female crab-eating monkeys (Macaca fascicularis), the morphology of the extensor group of thigh muscles is described and some functional indices (Stern, 1971) are calculated. For the attachment and measurements of muscles, the results obtained in this study generally agreed with those of otherMacaca species and New World monkeys reported by various authors. The functional indices did not show any significant differences between the right and left hindlimbs or between male and female series, and the following facts were confirmed: the origin of m. sartorius has a more anterior attachment than is found in man and anthropoid apes; the insertion of m. sartorius has a more distal attachment than is found in man and a more proximal than is found in anthropoid apes; the m. rectus femoris has only one tendon of origin in all cases; and, the origin of m. vastus lateralis is intermediate between good leaper and slow climber types.