Caldesmon: A calmodulin — Binding actin — Regulatory protein

The protein caldesmon, originally isolated from smooth muscle tissue where it is the most abundant calmodulin-binding protein, has since been shown to have a wide distribution in actin- and myosin- containing cells where it is localized in sub-cellular structures concerned with motility, shape changes and exo- or endo-cytosis. Caldesmon is believed to be an actin- regulatory protein, and binds with high affinity to actin or actin-tropomyosin. Caldesmon inhibits the activation by actin-tropomyosin of myosin MgATPase activity, and the inhibition can be reversed by Ca2+.calmodulin. The binding of caldesmon to smooth muscle proteins has been studied in detail, enabling a model to be constructed which could account for the observed Ca2+ regulation of smooth muscle thin filaments. The abundance of caldesmon, and the Ca2+-regulation of its activity via calmodulin, mean that it is potentially an important intracellular regulator of processes such as smooth muscle contraction, cell motility and secretion.     

t-Tests for Single Means of Autocorrelated Data — A Simulation Study —

A simulation study is reported in which the effect of positive and negative autocorrelation on the quantiles of Student's t-test variable is investigated. It is shown that negative autocorrelations lead to smaller quantiles. Positive autocorrelations lead to larger quantiles.     

BUCHBESPRECHUNGEN — BOOK REVIEWS

Book reviewed in this article: Seymour , P. R.: Invertebrates of Economic Importance in Britain . Maixner , M.: Untersuchungen zur Insektizidresistenz der Raubmilbe Typhlodromus pyri Scheuten (Acari, Phytoseiidae) an Reben des Weinbaugebiets Mosel-Saar-Ruwer . Gilbert , Pamela ; Hamilton , C. J.: Entomology. A. Guide to Information Sources . Wehner , R.; Gehring , W.: Zoologie . Gerson , U.; Smiley , R. L.: Acarine Biocontrol Agents . Tischler , W.: Ökologie der Lebensräume . Detmers , H.-B.: Untersuchungen zur biologischen Bedeutung des Holzes für den Großen Kornbohrer Prostephanus truncatus (Bostrychidae) . Haug , G.; H offmann , H. (edit.): Chemistry of Plant Protection . Vol. 2: Degradation of Pesticides, Desiccation and Defoliation, ACh-Receptors as Targets. Vol. 5. Naumann, K.: Synthetic Pyrethroid Insecticides. Chemistry and Patents. Spaar , D.; Kleinhempel , H.; Fritzsche , R.: Diagnose von Krankheiten und Beschädigungen an Kulturpflanzen . Band: Getreide, Mais und Futtergräser. Band: Öl- und Faserpflanzen. Hill , D. S.: Pests of Stored Products and their Control . Jie -Liu Xin : Agricultural Acarology .