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P. G. H. Gell 《BMJ (Clinical research ed.)》1945,2(4426):622-623
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F. Dudley Hart Denis Burley Roger Manley George Brown 《BMJ (Clinical research ed.)》1956,1(4965):496-497
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The structure-activity in α-alkylthio-cinnamyl penicillins was studied. These penicillins were prepared by condensing 6-aminopenicillanic acid with α-alkylthio-cinnamic acids. α-Methylthxo-cinnamyl penicillin and its substituted analogues were highly inhibitory to Staphylococcus aureus 209P and some of them were also effective in vitro against benzyl-penicillin-resistant Staphylococcus. trans-α-Methylthio-2-bromo-cinnamyl penicillin, which showed a good in vitro activity, was resistant to penicillinase and was stable in acidic aqueous solution. 相似文献