Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

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An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates

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OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

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A mitochondrial iron-responsive pathway regulated by DELE1

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Parp1 promotes sleep,which enhances DNA repair in neurons

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Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity

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Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

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OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

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Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

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PRMT6 methylation of RCC1 regulates mitosis,tumorigenicity, and radiation response of glioblastoma stem cells

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Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation,Mitochondrial Integrity,and Function

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linc-AAM Facilitates Gene Expression Contributing to Macrophage Activation and Adaptive Immune Responses

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TopBP1 assembles nuclear condensates to switch on ATR signaling

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A rapid RIG-I signaling relay mediates efficient antiviral response

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Divergent Roles for Macrophage C-type Lectin Receptors,Dectin-1 and Mannose Receptors,in the Intestinal Inflammatory Response

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Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

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Protein kinase ATR inhibits E3 ubiquitin ligase CRL4PRL1 to stabilize ribonucleotide reductase in response to replication stress

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