The Sister’s Hill Site: A Hell Gap Site In North-Central Wyoming

Abstract

The cultural horizon at the Sister’s Hill Site has produced typical Hell Gap points and a small group of associated artifacts. The radiocarbon date of 9650 ± 250 B. C. is in agreement with late Agate Basin or early post Agate Basin sites in the High Plains. On the basis of the current data, Hell Gap points appear to have developed from Agate Basin styles and seem to be developmental to Alberta, Scottsbluff and Eden types.     

Effects of Climate, Site Conditions, and Seed Quality on Recent Treeline Dynamics in NW Russia: Permafrost and Lack of Reproductive Success Hamper Treeline Advance?

Treeline advance alters albedo and carbon storage and is an important feedback mechanism to the global climate system. Establishment of trees north of the treeline requires favorable climate, suitable microsites, and viable seeds. Here we studied the influence of climate and microsite conditions on tree and seedling growth at four transects from forest through woodland to tundra in NW Russia, and tested the viability of seeds from the region. General growth patterns and establishment periods of the treeline species Picea obovata are similar across the study sites suggesting a regional driver (for example, climate). Individuals established as early as the 1640s, but mainly between 1850 and 1880, and during a major and continental scale establishment wave in the 1950s and 1960s. No establishment occurred after 1982. Older trees mainly showed significant and stable positive relationships to growing year summer temperatures and significant stable negative correlations to previous year summer temperatures in nearly all plots. Trees from the last establishment wave showed more mixed responses, but current year summer temperature positively affected growth. Active layer depth was similar in all plots with trees but decreased sharply in treeless tundra. A major role for the lack of recent establishment seems to be very low seed viability, possibly combined with early strong fall frosts, which might have severely limited successful recruitment in the last decades of the twentieth century. For a successful establishment of P. obovata in tundra areas of NW Russia, permafrost degradation and (generally) warmer winters might be a prerequisite.     

Psychological Mechanisms Predicting Wellbeing in Pet Owners: Rogers’ Core Conditions versus Bowlby’s Attachment

While pet ownership may confer physical and psychological health benefits, existing research presents inconsistent findings, and the psychological mechanisms through which health benefits might be conferred are unknown. Exploring human–pet relationships from the perspectives of Bowlby’s attachment theory, namely “attachment-related anxiety” and “attachment-related avoidance,” and Rogers’ core conditions including “unconditional positive regard” and “empathy” may highlight the psychological mechanisms involved. This study compared quality of life (QOL) and psychopathology in pet owners with those without pets. In the pet owners, we additionally assessed pet attachment, and perceived empathy, unconditionality, and congruence in the human–pet relationships. We then compared the relative value of Bowlby’s attachment versus Rogers’ core conditions in human– pet relationships as predictors of wellbeing in pet owners. Overall, pet owners and non-pet owners did not significantly differ in terms of QOL or psychopathology. However, in pet owners, secure pet attachments were associated with lower psychological distress and psychopathology, and those perceiving higher levels of Rogers’ core conditions from their pets had higher QOL. Bowlby’s pet attachment insecurity predicted psychological distress and psychopathology, while Rogers’ total core conditions in pets were significantly predictive of QOL of owners. Differences in wellbeing may not be reliably discernable between pet owners and non-pet owners, as wellbeing is related not to pet ownership alone but to qualities of individual human–pet relationships. The results provide new information about psychological mechanisms through which human–pet interactions are conferred, and support for the applicability of both Bowlby’s and Rogers’ concepts.     

Modelling the Effects of Selection Temperature and Mutation on the Prisoner’s Dilemma Game on a Complete Oriented Star

This paper models the prisoner’s dilemma game based on pairwise comparison in finite populations on a complete oriented star (COS). First, we derive a linear system on a COS for calculating the corresponding fixation probabilities that imply dependence of the selection temperature and mutation. Then we observe and analyze the effects of two parameters on fixation probability under different population sizes. In particular, it is found through the experimental results that (1) high mutation is more sensitive to the fixation probability than the low one when population size is increasing, while the opposite is the case when the number of cooperators is increasing, and (2) selection temperature demotes the fixation probability.     

Effects of Polyphenols on Brain Ageing and Alzheimer’s Disease: Focus on Mitochondria

The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases. Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especially Alzheimer's disease (AD). Hence, the risk of AD rises exponentially with age. While there is no cure currently available, sufficient intake of certain micronutrients and secondary plant metabolites may prevent disease onset. Polyphenols are highly abundant in the human diet, and several experimental and epidemiological evidences indicate that these secondary plant products have beneficial effects on AD risks. This study reviews current knowledge on the potential of polyphenols and selected polyphenol-rich diets on memory and cognition in human subjects, focusing on recent data showing in vivo efficacy of polyphenols in preventing neurodegenerative events during brain ageing and in dementia. Concentrations of polyphenols in animal brains following oral administration have been consistently reported to be very low, thus eliciting controversial discussion on their neuroprotective effects and potential mechanisms. Whether polyphenols exert any direct antioxidant effects in the brain or rather act by evoking alterations in regulatory systems of the brain or even the body periphery is still unclear. To understand the mechanisms behind the protective abilities of polyphenol-rich foods, an overall understanding of the biotransformation of polyphenols and identification of the various metabolites arising in the human body is also urgently needed.     

Influence of Incubation Conditions on Hydrolysis Efficiency and Iodine Enrichment in Baker’s Yeast

The influence of incubation conditions, enzyme type, hydrolysis time, and potassium iodide concentration on hydrolysis and iodine enrichment were studied in supernatant and pellets of Saccharomyces cervisiae hydrolysates. The type of enzyme used and incubation time significantly influence hydrolysis efficiency and protein concentration in supernatant and pellet. The highest protein hydrolysis efficiency was obtained by 24-h incubation with papain. Significantly lower values were observed for pepsin and autolysis. The potassium iodide concentration influences the iodine content of supernatant and pellet, but not hydrolysis. Iodide enrichment of supernatant and pellet depends on the concentration of iodide using during incubation. High concentration of iodide and long incubation times were the conditions for optimal iodide enrichment and high-protein hydrolysates. The optimal hydrolysis efficiency and iodine enrichment were obtained during 24-h incubation with papain in a 4.5-mM potassium iodide medium. The efficiency reached 98.22% with iodine concentrations of 2,664.91 and 9,200.67 μg/g iodine in pellet and supernatant, respectively.     

Effects of Modulations of the Visual Conditions on Subjects’ Perception of Their Own and Another Person’s Hand

According to current concepts, the execution of expedient actions well-coordinated in space becomes possible owing to the creation of a system for internal representation, which includes a body coordinate system, in the central nervous system. The goal of this study was to assess the effects induced by the exclusion of vision and a left-right inversion in visual space on the accuracy in the internal representation of hands and on aimed arm movements. The study cohort included 16 participants aged from 18 to 25 years. The experiment consisted of two test series. In the first series, a subject placed his/her left hand under a transparent plexiglass screen. Upon the experimenter’s command, the subject had to indicate the position of his/her left wrist and the terminal phalanges of the thumb, middle and little fingers with his/her right index finger on the plexiglass, which was accompanied by the corresponding marks displayed on the screen. The positional accuracy in the subject’s perception of his/her own hand position was recorded in the conditions of a leftright inversion of visual space, which were created by wearing prismatic spectacles and the exclusion of visual control. In the second case, the subject’s left hand was replaced on the table under the transparent screen by a similarly shaped left hand belonging to another person. It has been shown that the positions of the middle fingertip and the wrist were sufficiently precisely perceived by the subject through prismatic spectacles. However, the position of the tips of the thumb and little finger relative to the axis connecting the wrist and the terminal phalanx of the middle finger (the hand axis) was perceptually inverted. The accuracy of the indication was reduced for all fingers when the eyes were closed. In testing another person’s hand, a left–right inversion in the visual space created an illusory 90° turn of the hand’s axis and an illusory bias relative to the wrist towards elongation in the marker points corresponding to another person’s fingers. We can suggest that when the alien hand replaced the subject’s own hand, in accordance with the modulations in the motor task conditions, the egocentric system of coordinates was replaced by the allocentric system. The role of vision in the execution of spatially oriented and accurate hand movements increased in this case.     

Effects of training and weight support on muscle activation in Parkinson’s disease

The aim of this study was to investigate the effect of high-intensity locomotor training on knee extensor and flexor muscle activation and adaptability to increased body-weight (BW) support during walking in patients with Parkinson’s disease (PD). Thirteen male patients with idiopathic PD and eight healthy participants were included. The PD patients completed an 8-week training program on a lower-body, positive-pressure treadmill. Knee extensor and flexor muscles activation during steady treadmill walking (3 km/h) were measured before, at the mid-point, and after training. Increasing BW support decreased knee extensor muscle activation (normalization) and increased knee flexor muscle activation (abnormal) in PD patients when compared to healthy participants. Training improved flexor peak muscle activation adaptability to increased (BW) support during walking in PD patients. During walking without BW support shorter knee extensor muscle off-activation time and increased relative peak muscle activation was observed in PD patients and did not improve with 8 weeks of training. In conclusion, patients with PD walked with excessive activation of the knee extensor and flexor muscles when compared to healthy participants. Specialized locomotor training may facilitate adaptive processes related to motor control of walking in PD patients.     

Levodopa Effects on Hand and Speech Movements in Patients with Parkinson’s Disease: A fMRI Study

Levodopa (L-dopa) effects on the cardinal and axial symptoms of Parkinson’s disease (PD) differ greatly, leading to therapeutic challenges for managing the disabilities in this patient’s population. In this context, we studied the cerebral networks associated with the production of a unilateral hand movement, speech production, and a task combining both tasks in 12 individuals with PD, both off and on levodopa (L-dopa). Unilateral hand movements in the off medication state elicited brain activations in motor regions (primary motor cortex, supplementary motor area, premotor cortex, cerebellum), as well as additional areas (anterior cingulate, putamen, associative parietal areas); following L-dopa administration, the brain activation profile was globally reduced, highlighting activations in the parietal and posterior cingulate cortices. For the speech production task, brain activation patterns were similar with and without medication, including the orofacial primary motor cortex (M1), the primary somatosensory cortex and the cerebellar hemispheres bilaterally, as well as the left- premotor, anterior cingulate and supramarginal cortices. For the combined task off L-dopa, the cerebral activation profile was restricted to the right cerebellum (hand movement), reflecting the difficulty in performing two movements simultaneously in PD. Under L-dopa, the brain activation profile of the combined task involved a larger pattern, including additional fronto-parietal activations, without reaching the sum of the areas activated during the simple hand and speech tasks separately. Our results question both the role of the basal ganglia system in speech production and the modulation of task-dependent cerebral networks by dopaminergic treatment.     

Everything’s Relative? Relative Differences in Processing Fluency and the Effects on Liking

Explanations of aesthetic pleasure based on processing fluency have shown that ease-of-processing fosters liking. What is less clear, however, is how processing fluency arises. Does it arise from a relative comparison among the stimuli presented in the experiment? Or does it arise from a comparison to an internal reference or standard? To address these questions, we conducted two experiments in which two ease-of-processing manipulations were applied: either (1) within-participants, where relative comparisons among stimuli varying in processing ease were possible, or (2) between-participants, where no relative comparisons were possible. In total, 97 participants viewed simple line drawings with high or low visual clarity, presented at four different presentation durations, and rated for felt fluency, liking, and certainty. Our results show that the manipulation of visual clarity led to differences in felt fluency and certainty regardless of being manipulated within- or between-participants. However, liking ratings were only affected when ease-of-processing was manipulated within-participants. Thus, feelings of fluency do not depend on the nature of the reference. On the other hand, participants liked fluent stimuli more only when there were other stimuli varying in ease-of-processing. Thus, relative differences in fluency seem to be crucial for liking judgments.     

Artificial Selection and Domestication: Modern Lessons from Darwin’s Enduring Analogy

It is clear from his published works that Charles Darwin considered domestication to be very useful in exploring and explaining mechanisms of evolutionary change. Not only did domestication occupy the introductory chapter of On the Origin of Species, but he revisited the topic in a two-volume treatise less than a decade later. In addition to drawing much of his information about heredity from studies of domesticated animals and plants, Darwin saw important parallels between the process of artificial selection by humans and natural selection by the environment. There was resistance to this analogy even among Darwin’s contemporary supporters when it was proposed, and there also has been disagreement among historians and philosophers regarding the role that the analogy with artificial selection actually played in the discovery of natural selection. Regardless of these issues, the analogy between artificial and natural selection remains important in both research and education in evolution. In particular, the present article reviews ten lessons about evolution that can be drawn from the modern understanding of domestication and artificial selection. In the process, a basic overview is provided of current approaches and knowledge in this rapidly advancing field.

Mineralization and non-ideality: on nature’s foundry

Understanding how ions, ion-clusters and particles behave in non-ideal environments is a fundamental question concerning planetary to atomic scales. For biomineralization phenomena wherein diverse inorganic and organic ingredients are present in biological media, attributing biomaterial composition and structure to the chemistry of singular additives may not provide a holistic view of the underlying mechanisms. Therefore, in this review, we specifically address the consequences of physico-chemical non-ideality on mineral formation. Influences of different forms of non-ideality such as macromolecular crowding, confinement and liquid-like organic phases on mineral nucleation and crystallization in biological environments are presented. Novel prospects for the additive-controlled nucleation and crystallization are accessible from this biophysical view. In this manner, we show that non-ideal conditions significantly affect the form, structure and composition of biogenic and biomimetic minerals.     

Focus: Sex and Gender Health: The Effects of Gender-based Violence on Women’s Unwanted Pregnancy and Abortion

The aim of this research is to understand how gender-based violence across the life-course affects the likelihood of abortion. Women outpatients (n = 309) revealed their exposure to four different forms of gender-based abuse: child sexual abuse (25.7 percent), teenage physical dating violence (40.8 percent), intimate partner violence (43.1 percent), and sexual assault outside an intimate relationship (22 percent). Logistic regressions revealed that no single form of gender-based abuse predicted abortion. The cumulative effect of multiple forms of abuse did increase the odds of having an abortion (OR = 1.39, CI = 1.13-1.69). Child sexual abuse predicted intimate partner violence (OR = 6.71, CI = 3.36-13.41). The cumulative effect of gender-based violence on women’s reproductive health warrants further research. Priority should be given to screening for multiple forms of victimization in reproductive healthcare settings.     

Evolution and Biogeography: Leading Students in Darwin’s and Wallace’s Footsteps

Exploring life??s diversity and geography??s effect on it was central to Darwin and Wallace??s parallel discoveries of evolution. Those discoveries required the two to overcome their own misconceptions about species and biology. By helping students to see the world through the eyes of explorers and placing life??s diversity into a geographic context, teachers can help students overcome those same barriers to the acceptance of evolution and deepen students?? appreciation of biodiversity.     

Effects of Textured Insoles on Balance in People with Parkinson’s Disease

Background

Degradation of the somatosensory system has been implicated in postural instability and increased falls risk for older people and Parkinson’s disease (PD) patients. Here we demonstrate that textured insoles provide a passive intervention that is an inexpensive and accessible means to enhance the somatosensory input from the plantar surface of the feet.

Methods

20 healthy older adults (controls) and 20 participants with PD were recruited for the study. We evaluated effects of manipulating somatosensory information from the plantar surface of the feet using textured insoles. Participants performed standing tests, on two different surfaces (firm and foam), under three footwear conditions: 1) barefoot; 2) smooth insoles; and 3) textured insoles. Standing balance was evaluated using a force plate yielding data on the range of anterior-posterior and medial-lateral sway, as well as standard deviations for anterior-posterior and medial-lateral sway.

Results

On the firm surface with eyes open both the smooth and textured insoles reduced medial-lateral sway in the PD group to a similar level as the controls. Only the textured insole decreased medial-lateral sway and medial-lateral sway standard deviation in the PD group on both surfaces, with and without visual input. Greatest benefits were observed in the PD group while wearing the textured insoles, and when standing on the foam surface with eyes closed.

Conclusions

Data suggested that textured insoles may provide a low-cost means of improving postural stability in high falls-risk groups, such as people with PD.     

Conditions on the Earth’s surface 4–4.6 Ga: Primary syntheses

4–4.6 Ga the Earth’s surface was probably mainly cold with some hot spots which resulted from impacts. A system so largely heterogeneous (in temperature) could have provided possibilities for processes of primary syntheses of organic compounds.