共查询到20条相似文献,搜索用时 15 毫秒
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Anna Wade Andrew McKinney Joanna J. Phillips 《Biochimica et Biophysica Acta (BBA)/General Subjects》2014
Background
Neural stem/progenitor cells (NSPCs) reside within a complex and dynamic extracellular microenvironment, or niche. This niche regulates fundamental aspects of their behavior during normal neural development and repair. Precise yet dynamic regulation of NSPC self-renewal, migration, and differentiation is critical and must persist over the life of an organism.Scope of review
In this review, we summarize some of the major components of the NSPC niche and provide examples of how cues from the extracellular matrix regulate NSPC behaviors. We use proteoglycans to illustrate the many diverse roles of the niche in providing temporal and spatial regulation of cellular behavior.Major conclusions
The NSPC niche is comprised of multiple components that include; soluble ligands, such as growth factors, morphogens, chemokines, and neurotransmitters, the extracellular matrix, and cellular components. As illustrated by proteoglycans, a major component of the extracellular matrix, the NSPC, niche provides temporal and spatial regulation of NSPC behaviors.General significance
The factors that control NSPC behavior are vital to understand as we attempt to modulate normal neural development and repair. Furthermore, an improved understanding of how these factors regulate cell proliferation, migration, and differentiation, crucial for malignancy, may reveal novel anti-tumor strategies. This article is part of a Special Issue entitled Matrix-mediated cell behaviour and properties. 相似文献2.
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Background
Gene clustering has been widely used to group genes with similar expression pattern in microarray data analysis. Subsequent enrichment analysis using predefined gene sets can provide clues on which functional themes or regulatory sequence motifs are associated with individual gene clusters. In spite of the potential utility, gene clustering and enrichment analysis have been used in separate platforms, thus, the development of integrative algorithm linking both methods is highly challenging. 相似文献11.
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《Cell》2023,186(2):327-345.e28
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Neuron types are the building blocks of the nervous system, and therefore, of functional circuits. Understanding the origin of neuronal diversity has always been an essential question in neuroscience and developmental biology. While knowledge on the molecular control of their diversification has largely increased during the last decades, it is now possible to reveal the dynamic mechanisms and the actual stepwise molecular changes occurring at single-cell level with the advent of single-cell omics technologies and analysis with high temporal resolution. Here, we focus on recent advances in the field and in technical and analytical tools that enable detailed insights into the emergence of neuron types in the central and peripheral nervous systems. 相似文献
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Bourbon HM Aguilera A Ansari AZ Asturias FJ Berk AJ Bjorklund S Blackwell TK Borggrefe T Carey M Carlson M Conaway JW Conaway RC Emmons SW Fondell JD Freedman LP Fukasawa T Gustafsson CM Han M He X Herman PK Hinnebusch AG Holmberg S Holstege FC Jaehning JA Kim YJ Kuras L Leutz A Lis JT Meisterernest M Naar AM Nasmyth K Parvin JD Ptashne M Reinberg D Ronne H Sadowski I Sakurai H Sipiczki M Sternberg PW Stillman DJ Strich R Struhl K Svejstrup JQ Tuck S Winston F Roeder RG Kornberg RD 《Molecular cell》2004,14(5):553-557