共查询到20条相似文献,搜索用时 15 毫秒
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Virulence of nocardiae 总被引:10,自引:0,他引:10
A Gonzalez Ochoa 《Canadian journal of microbiology》1973,19(8):901-904
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R. Alan Wilson 《Microbes and infection / Institut Pasteur》2012,14(15):1442-1450
This review considers whether the products of schistosomes in the mammalian host can be considered as virulence factors. These include: the cercarial secretions used in infection, those of the migrating schistosomulum, surface-exposed proteins of adult worms in the portal system and their gut vomitus in the context of immune evasion, secretions of the egg facilitating its escape from gut tissues and micro-exon gene products. 相似文献
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Virulence of Mycobacterium tuberculosis 总被引:1,自引:0,他引:1
John M. Grange 《FEMS microbiology letters》1985,32(1):55-60
Abstract Different strains of Candida albicans show varied sensitivities to the peptide analogues bacilysin, polyoxins and nikkomycins. From a sensitive strain, B2630, spontaneous mutants were selected for resistance to each analogue; certain mutants showed cross-resistance to other analogues and associated defects in peptide transport. A bacilysin-resistant mutant was cross resistant to the other analogues and to m -fluorophenylalanyl-Ala (FPA) but retained sensitivity to m -fluorophenylalanyl-Ala—Ala (FPAA). It showed defective dipeptide transport but normal oligopeptide transport. A revertant, selected for its ability to utilize Ala-Ala as sole nitrogen source, regained wild-type dipeptide transport activity and analogue sensitivity. Thus, C. albicans has distinguishable mechanisms for dipeptide and oligopeptide transport which can be exploited for uptake of peptide-drug adducts. 相似文献
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Virulence and pathogenesis 总被引:3,自引:0,他引:3
Weiss RA 《Trends in microbiology》2002,10(7):314-317
Why do viruses cause disease? As intracellular parasites they grow at the expense of the host, yet many infections are non-virulent. We tend to focus on unusual outcomes of infection that are important to the individual but trivial for host-parasite evolution, for example, paralytic polio or viral cancer. The assumption that the features of disease help onward transmission of the virus is true for, say, rabies, but not for AIDS or neurodegenerative diseases. Moreover, minor host differences can result in major changes in pathogen virulence. Although viral burden relates to disease severity, pathogenesis is not necessarily coupled with transmission dynamics. 相似文献
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Virulence factors of Burkholderia cepacia 总被引:8,自引:0,他引:8
James W. Nelson Sarah L. Butler Deborah Krieg John R.W. Govan 《FEMS immunology and medical microbiology》1994,8(2):89-97
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The evolution of Mycobacterium tuberculosis presents several challenges for public health. HIV and resistance to antimycobacterial medications have evolutionary implications
for how Mycobacterium tuberculosis will evolve, as these factors influence the host environment and transmission dynamics of tuberculosis strains. We present
an evolutionary invasion analysis of tuberculosis that characterizes the direction of tuberculosis evolution in the context
of different natural and human-driven selective pressures, including changes in tuberculosis treatment and HIV prevalence.
We find that the evolution of tuberculosis virulence can be affected by treatment success rates, the relative transmissibility
of emerging strains, the rate of reactivation from latency among hosts, and the life expectancy of hosts. We find that the
virulence of tuberculosis strains may also increase as a consequence of rising HIV prevalence, requiring faster case detection
strategies in areas where the epidemics of HIV and tuberculosis collide. 相似文献
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Virulence factors of Bordetella pertussis 总被引:4,自引:0,他引:4
Frits R. Mooi 《Antonie van Leeuwenhoek》1988,54(5):465-474
Clearly, B. pertussis has evolved very elaborate mechanisms to maintain itself in the human host. Three different proteins (FHA, pertussis toxin and fimbriae) have been implicated in adherence. Furthermore, a number of toxins are produced (pertussis toxin, adenylate cyclase, dermonecrotic toxin, and tracheal cytotoxin) which destroy the clearance mechanisms of the respiratory tract, or suppress the immune response. There is evidence that B. pertussis may survive intracellularly, and the possibility that it is a facultative intracellular parasite should certainly be explored. The availability of a large number of cloned virulence genes, and a system to construct well defined mutants by allelic exchange (Stibbitz et al. 1986) will greatly facilitate the study of Bordetella virulence factors at the molecular level. It opens the possibility to construct avirulent strains, which are still able to colonize and stimulate the local immune response. Such strains may be used as live, oral vaccines, to present (heterologous) antigens to the mucosal immune system of the respiratory tract. 相似文献
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Virulence factors of oral treponemes 总被引:9,自引:0,他引:9
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Jean François Dubremetz Maryse Lebrun 《Microbes and infection / Institut Pasteur》2012,14(15):1403-1410
Toxoplasma gondii virulence is dependent on factors involved in either parasite-host cell interaction, or in host immune response. It is essentially defined in the mouse and little is known concerning human infection. The genetic dependence of virulence is a growing field, benefiting from the recent development of research of the population structure of T. gondii. 相似文献
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The contemporary data on the genetical control of invasion process in dysentery causative agent coded by the virulence plasmids of the bacteria are presented. The examples of plasmid genes expression regulated by the genes-regulators located on the chromosome are presented. The mechanism for virulence genes regulation is discussed. 相似文献
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The Epidemiological Virulence of Staphylococci 总被引:3,自引:1,他引:2
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Zachary D. Dalebroux Sarah L. Svensson Erin C. Gaynor Michele S. Swanson 《Microbiology and molecular biology reviews》2010,74(2):171-199
Summary: Like for all microbes, the goal of every pathogen is to survive and replicate. However, to overcome the formidable defenses of their hosts, pathogens are also endowed with traits commonly associated with virulence, such as surface attachment, cell or tissue invasion, and transmission. Numerous pathogens couple their specific virulence pathways with more general adaptations, like stress resistance, by integrating dedicated regulators with global signaling networks. In particular, many of nature''s most dreaded bacteria rely on nucleotide alarmones to cue metabolic disturbances and coordinate survival and virulence programs. Here we discuss how components of the stringent response contribute to the virulence of a wide variety of pathogenic bacteria. 相似文献
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致肾盂肾炎大肠杆菌的毒力因子和调控 总被引:2,自引:0,他引:2
致肾盂肾炎大肠杆菌引起人的尿路感染,它的毒力因子包括表面毒力因子和分泌毒力因子两大类。表面毒力因子包括菌毛、鞭毛、黏附素和多糖类物质,主要在细菌的侵染过程中起作用。分泌毒力因子主要是溶血素、细胞毒性坏死因子等毒素蛋白,主要对宿主细胞产生毒力作用。本文简要综述致肾盂肾炎大肠杆菌毒力因子分泌所需要的5种分泌机制,并论及毒力因子的宏观调控和影响毒力调控的因素。 相似文献