Probiotics as an Adjunct Therapy for the Treatment of Halitosis,Dental Caries and Periodontitis

Probiotics and Antimicrobial Proteins - Probiotics and prebiotics are popular among consumers worldwide as natural approaches to prevent gastrointestinal diseases. The effects of their consumption...     

Isolation of Lactic Acid Bacteria from Intestine of Freshwater Fishes and Elucidation of Probiotic Potential for Aquaculture Application

Probiotics and Antimicrobial Proteins - Probiotics play significant roles in enhancing systemic immunity, improving intestinal balance and feed value, enhancing enzymatic digestion, and inhibiting...     

Evaluation of the Role of Probiotics As a New Strategy to Eliminate Microbial Toxins: a Review

Probiotics and Antimicrobial Proteins - Probiotics are living microorganisms that have favorable effects on human and animal health. The most usual types of microorganisms recruited as probiotics...     

Effects of Dietary Supplementation with Bacillus amyloliquefaciens US573 on Intestinal Morphology and Gut Microbiota of European Sea Bass

Probiotics and Antimicrobial Proteins - Probiotics or direct-fed microbials (DFM) have proven strong potential for improving aquaculture sustainability. This study aims to evaluate the effects of...     

Anti-rotavirus Properties and Mechanisms of Selected Gram-Positive and Gram-Negative Probiotics on Polarized Human Colonic (HT-29) Cells

Probiotics and Antimicrobial Proteins - Probiotics have been investigated to improve the universal rotavirus (RV) vaccination as well as to ameliorate the RV infection. However, underlying...     

Integrated Phenotypic-Genotypic Analysis of Candidate Probiotic Weissella Cibaria Strains Isolated from Dairy Cows in Kuwait

Probiotics and Antimicrobial Proteins - Probiotics represent a possible strategy for controlling intestinal infections in livestock. Members of the Weissella genus are increasingly being studied...     

益生菌在炎症性肠病治疗中的研究进展

益生菌（Probiotics）是一类能够促进肠道微生物菌群平衡,对宿主健康或生理功能产生有益作用的活性微生物。目前广泛应用于生命健康领域、科学研究、生物工程、工农业以及食品安全。大量国内外研究表明益生菌在降血压、降血糖、降血脂、抗过敏、抗炎、调节免疫、维持肠道菌群平衡等方面具有积极作用。炎症性肠病的病因和发病机制尚未完全明确,现多认为与遗传、环境、感染、免疫以及肠道微生物多因素相互作用有关。益生菌通过多种机制介导,在临床治疗炎症性肠病中扮演着重要角色。     

水产养殖中益生菌研究进展

益生菌在水产养殖中能够净化水质、预防疾病、促进生长且安全、环保、无抗性,是抗生素的理想替代品,具有重要的研究价值和广阔的应用前景。本文主要从益生菌制剂的定义概述、作用机理及特性进行阐述,分析益生菌制剂存在的问题,探讨水产养殖用益生菌制剂的研究方向。     

益生菌的安全性

益生菌是一类重要的微生物调节剂,对人类的营养和健康具有重大的意义。目前,益生菌具有医疗和保健作用毋庸质疑,但是对于益生菌的安全性还存在争议。本文对益生菌的安全性和不安全性研究进行综述,以利于临床正确认识、了解和使用益生菌制剂,对进一步开发利用益生菌也有积极意义。 更多还原     

益生菌与肠黏膜互作的分子机制研究进展

益生菌是一类定植于动物肠道,可辅助动物消化功能,维护肠道菌群平衡并可影响肠道免疫系统,有益于动物健康的重要调节性菌群。该类菌群与动物肠上皮细胞间互作的分子机制包括菌体表面分子如磷脂壁酸（phosphatidicacid,LTA）、表面层蛋白（Slayerprotein）等与宿主的粘附相关蛋白分子结合,通过占位效应抑制有害菌群在肠道内的定植;益生菌还可刺激肠道细胞分泌B防御素2、细菌素和有机酸等可抑制甚至杀灭有害菌群;在益生菌作用下,肠道上皮细胞可增强粘液糖蛋白、紧密连接蛋白occludin和ZO-1等分子的表达,加厚并加固肠道黏膜屏障;益生菌相关抗原可通过与抗原递呈细胞表面模式识别受体（TLRs等）分子结合,激活递呈细胞,启动各免疫细胞的交互作用,调节肠道免疫状态。     

益生菌在肿瘤防治中的机制和应用

益生菌是指一类通过添加到食品或药品中,能够起到调节肠道微生态平衡,从而对人或动物产生有利影响的微生物。近年来,人们对益生菌的特性、分类、分布与营养的研究很多,特别是益生菌在抗肿瘤方面的作用引起了国内外学者的广泛关注。本文综述了益生菌应用于肿瘤预防、治疗及预后的研究情况,并对益生菌未来的研究方向提出个人的观点和展望。     

益生菌对口腔微生物的影响

益生菌(Probiotic)是添加入食物的能够增加营养摄入并改善人体肠道菌群平衡的活菌。大量研究认为益生菌有促进人体健康的作用,目前研究主要集中在益生菌促进人体肠道菌群平衡的作用。口腔是消化道的起始端,最先接触到益生菌并且也有其特有的微生态系统,近年来越来越多的研究关注益生菌对口腔微生物的作用。本文主要从益生菌在口腔的定植,益生菌对口腔微生物群落的影响,益生菌对口腔细菌作用机制三个方面对近年来益生菌对口腔微生物的影响进行综述。     

Probiotics importance and their immunomodulatory properties

Mammalian intestine contains a large diversity of commensal microbiota, which is far more than the number of host cells. Probiotics play an insecure and protective role against the colonization of intestinal pathogenic microbes and increase mucosal integrity by stimulating epithelial cells. Probiotics have innate capabilities in many ways, including receptor antagonism, receptor expression, binding and expression of adapter proteins, expression of negative regulatory signal molecules, induction of microRNAs, endotoxin tolerance, and ultimately secretion of immunomodulatory proteins, lipids, and metabolites to modulate the immune system. Probiotic bacteria can affect homeostasis, inflammation, and immunopathology through direct or indirect effects on signaling pathways as immunosuppressant or activators. Probiotics suppress inflammation by inhibiting various signaling pathways such as the nuclear factor-κB (NF-κβ) pathway, possibly related to alterations in mitogen-activated protein kinases and pattern recognition receptors pathways. Probiotics can also inhibit the binding of lipopolysaccharides to the CD14 receptor, thereby reducing the overall activation of NF-κβ and producing proinflammatory cytokines. Some effects of modulation by probiotics include cytokine production by epithelial cells, increased mucin secretion, increased activity of phagocytosis, and activation of T and natural killer T cells, stimulation of immunoglobulin A production and decreased T cell proliferation. Intestinal microbiota has a major impact on the systemic immune system. Specific microbiota controls the differentiation of cells in lamina propria, in which Th17 cells secrete interleukin 17. The presence of Th17 and Treg cells in the small intestine is associated with intestinal microbiota, with the preferential Treg differentiation and the absence of Th17 cells, possibly reflecting alterations in the lamina propria cytokines and the intestinal gut microbiota.     

益生菌、益生元对慢性肾脏疾病治疗的研究进展

益生菌是近些年来的研究热点,其对人体的有益作用越来越被关注,其在治疗众多疾病上有显著效果,本文将分析和总结益生菌对慢性肾脏疾病(chronic kidney disease,CKD)方面的重要影响。益生菌通过黏液层、上皮层、肠相关淋巴组织这三个层次对肠道进行作用,并且增加黏液和上皮细胞紧密连接以及上皮细胞的存活力来增强肠道屏障,而且又可以发挥营养作用。在其对CKD的影响中,益生菌、益生元和合生元可以降低尿毒症毒素,也可以减少免疫炎症的反应,提高肾功能和生活质量。益生菌组合剂量、益生菌与益生元组合方式都会影响益生菌制剂的效果,并且个体肠道的差异以及抗生素的使用等也都对实验有影响。本综述包括了益生菌对CKD的潜在作用机制和研究方法的进展,对以后精准医疗模式下防治CKD提供新的思路和靶点。     

Designing Anti-Microbial Peptides Against Major β-Lactamase Enzymes in Clinically Important Gram-Negative Bacterial Pathogens: An In-Silico Study

Probiotics and Antimicrobial Proteins - Anti-microbial resistance (AMR) creating healthcare concerns worldwide requires ardent exploration of therapeutic alternatives. Although anti-microbial...     

Protective Efficacy of a Pseudoalteromonas Strain in European Abalone,Haliotis tuberculata,Infected with Vibrio harveyi ORM4

Probiotics and Antimicrobial Proteins - The hemolymph of healthy marine invertebrates is known to harbor antibiotic-producing bacteria belonging to the genus Pseudoalteromonas. Such strains are...     

Association of Vitamin B12, Lactate Dehydrogenase,and Regulation of NF-κB in the Mitigation of Sodium Arsenite-Induced ROS Generation in Uterine Tissue by Commercially Available Probiotics

Probiotics and Antimicrobial Proteins - Managing arsenic intoxication with conventional metal chelators is a global challenge. The present study demonstrated the therapeutic role of probiotics...     

Probiotics manipulate host cytokine response and induce antimicrobial peptides

Probiotics modulate production of both cytokine and antimicrobial peptides. This effect can be regarded as a part of complex interplay between them and the host.     

Newly Isolated Lactobacilli strains from Algerian Human Vaginal Microbiota: Lactobacillus fermentum Strains Relevant Probiotic’s Candidates

Probiotics and Antimicrobial Proteins - Lactobacilli strains are considered as a preventive means for treatment of vaginal infections or post-antibiotic treatment to repopulate the vaginal mucosa....     

Psychobiotic Potential of Gamma-Aminobutyric Acid–Producing Marine Enterococcus faecium SH9 from Marine Shrimp

Probiotics and Antimicrobial Proteins - Psychobiotics are a novel class of probiotics with potential to confer mental wellness via production of neuroactive compounds such as gamma-aminobutyric...