共查询到20条相似文献,搜索用时 31 毫秒
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Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin 总被引:8,自引:0,他引:8
del Río B García Pedrero JM Martínez-Campa C Zuazua P Lazo PS Ramos S 《The Journal of biological chemistry》2004,279(37):38294-38302
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Smad4 as a transcription corepressor for estrogen receptor alpha 总被引:7,自引:0,他引:7
Wu L Wu Y Gathings B Wan M Li X Grizzle W Liu Z Lu C Mao Z Cao X 《The Journal of biological chemistry》2003,278(17):15192-15200
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Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters 总被引:3,自引:0,他引:3
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Kininis M Chen BS Diehl AG Isaacs GD Zhang T Siepel AC Clark AG Kraus WL 《Molecular and cellular biology》2007,27(14):5090-5104
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O'Brien JE Peterson TJ Tong MH Lee EJ Pfaff LE Hewitt SC Korach KS Weiss J Jameson JL 《The Journal of biological chemistry》2006,281(36):26683-26692
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Kouzmenko AP Takeyama K Ito S Furutani T Sawatsubashi S Maki A Suzuki E Kawasaki Y Akiyama T Tabata T Kato S 《The Journal of biological chemistry》2004,279(39):40255-40258
Wnt and estrogen signaling represent important regulatory pathways, each controlling a wide range of biological processes. While an increasing number of observations suggest potential convergence between these pathways, no direct evidence of their functional interaction has been reported. Using human colon and breast cancer cells, we found that estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes, reciprocally enhanced the transactivation of cognate reporter genes, and were reciprocally recruited to cognate response elements in the promoters of endogenous target genes. Using transgenic Drosophila that ectopically expressed human ERalpha alone or together with metabolically stable beta-catenin/Armadillo mutants, we demonstrated genetic interaction between these signal transducers in vivo. Thus, we present here the first direct evidence of cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha. 相似文献
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