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Extracellular Nucleotide Hydrolysis in Dermal and Limbal Mesenchymal Stem Cells: A Source of Adenosine Production
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Liliana I. Sous Naasani Cristiano Rodrigues Rafael Paschoal de Campos Liziane Raquel Beckenkamp Isabele C. Iser Ana Paula Santin Bertoni Márcia R. Wink 《Journal of cellular biochemistry》2017,118(8):2430-2442
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De Luca A Lamura L Gallo M Maffia V Normanno N 《Journal of cellular biochemistry》2012,113(11):3363-3370
Several different cytokines and growth factors secreted by mesenchymal stem cells (MSCs) have been hypothesized to play a role in breast cancer progression. By using a small panel of breast cancer cell lines (MCF‐7, T47D, and SK‐Br‐3 cells), we analyzed the role of interleukin‐6 (IL‐6) and vascular endothelial growth factor A (VEGF) in the cross‐talk between MSCs and breast cancer cells. We performed migration assays in which breast cancer cells were allowed to migrate in response to conditioned medium from MSCs (MSCs‐CM), in absence or in presence of the anti‐VEGF antibody bevacizumab or an anti‐IL‐6 antibody, alone or in combination. We found that anti‐VEGF and anti‐IL‐6 antibodies inhibited the migration of breast cancer cells and that the combination had an higher inhibitory effect. We next evaluated the effects of recombinant VEGF and IL‐6 proteins on breast cancer cell growth and migration. IL‐6 and VEGF had not significant effects on the proliferation of breast carcinoma cells. In contrast, both VEGF and IL‐6 significantly increased the ability to migrate of MCF‐7, T47D and SK‐Br‐3 cells, with the combination showing a greater effect as compared with treatment with a single protein. The combination of VEGF and IL‐6 produced in breast cancer cells a more significant and more persistent activation of MAPK, AKT, and p38MAPK intracellular signaling pathways. These results suggest that MSC‐secreted IL‐6 and VEGF may act as paracrine factors to sustain breast cancer cell migration. J. Cell. Biochem. 113: 3363–3370, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
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Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia
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Alessandra Carcereri de Prati Elena Butturini Antonella Rigo Elisa Oppici Michele Rossin Diana Boriero Sofia Mariotto 《Journal of cellular biochemistry》2017,118(10):3237-3248
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Influence of Mesenchymal Stem Cells Conditioned Media on Proliferation of Urinary Tract Cancer Cell Lines and Their Sensitivity to Ciprofloxacin
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Malgorzata Maj Anna Bajek Ewelina Nalejska Dorota Porowinska Tomasz Kloskowski Lidia Gackowska Tomasz Drewa 《Journal of cellular biochemistry》2017,118(6):1361-1368
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Functional and Structural Assessment of the Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in Doxorubicin‐Induced Cardiotoxicity
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Somia H. Abd Allah Samia Hussein Mai M. Hasan Raghda H. A. Deraz Wafaa F. Hussein Laila M. E. Sabik 《Journal of cellular biochemistry》2017,118(10):3119-3129
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Irradiation of Mesenchymal Stromal Cells With Low and High Doses of Alpha Particles Induces Senescence and/or Apoptosis
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Nicola Alessio Giuseppe Esposito Giovanni Galano Roberto De Rosa Pasquale Anello Gianfranco Peluso Maria Antonella Tabocchini Umberto Galderisi 《Journal of cellular biochemistry》2017,118(9):2993-3002
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PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells,Involving Autophagy
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Damián E. Berardi Carolina Flumian Cristina E. Rodriguez María I. Díaz Bessone Stefano M. Cirigliano Elisa D. Bal de Kier Joffé Gabriel L. Fiszman Alejandro J. Urtreger Laura B. Todaro 《Journal of cellular biochemistry》2016,117(3):730-740