共查询到20条相似文献,搜索用时 15 毫秒
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A Protein Encoded by the Latency-Related Gene of Bovine Herpesvirus 1 Is Expressed in Trigeminal Ganglionic Neurons of Latently Infected Cattle and Interacts with Cyclin-Dependent Kinase 2 during Productive Infection 总被引:6,自引:5,他引:1
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Yunquan Jiang Ashfaque Hossain Maria Teresa Winkler Todd Holt Alan Doster Clinton Jones 《Journal of virology》1998,72(10):8133-8142
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Bovine herpesvirus 1 (BHV-1) infection induces clinical symptoms in the upper respiratory tract, inhibits immune responses, and can result in life-threatening secondary bacterial infections. Following acute infection, BHV-1 establishes latency in sensory neurons within trigeminal ganglia. Periodically, reactivation from latency occurs, resulting in virus transmission. The latency-related (LR) RNA is abundantly expressed in latently infected sensory neurons, suggesting that LR gene products regulate the latency-reactivation cycle. An LR mutant virus with stop codons at the amino terminus of the first open reading frame (ORF) in the LR gene (ORF2) does not reactivate from latency, in part because it induces higher levels of apoptosis in infected neurons. ORF2 inhibits apoptosis in transiently transfected cells, suggesting that it plays an important role in the latency-reactivation cycle. ORF2 also interacts with Notch1 or Notch3 and consequently inhibits their ability to trans-activate the bICP0 early and glycoprotein C promoters. In this study, we identified ORF2 sequences that were necessary for inhibiting cold shock-induced apoptosis or Notch1-mediated trans-activation of the bICP0 early promoter and stimulation of productive infection. Relative to ORF2 sequences necessary for inhibiting apoptosis, distinct domains in ORF2 were important for interfering with Notch1-mediated trans-activation. Five consensus protein kinase A and/or protein kinase C phosphorylation sites within ORF2 regulate the steady-state levels of ORF2 in transfected cells. A nuclear localization signal in ORF2 was necessary for inhibiting Notch1-mediated trans-activation but not apoptosis. In summary, ORF2 has more than one functional domain that regulates its stability and functional properties. 相似文献
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Leticia Frizzo da Silva Insun Kook Alan Doster Clinton Jones 《Journal of virology》2013,87(20):11214-11222
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A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. 总被引:9,自引:0,他引:9
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Guey-Chuen Perng Barak Maguen Ling Jin Kevin R. Mott Nelson Osorio Susan M. Slanina Ada Yukht Homayon Ghiasi Anthony B. Nesburn Melissa Inman Gail Henderson Clinton Jones Steven L. Wechsler 《Journal of virology》2002,76(3):1224-1235
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Workman A Eudy J Smith L da Silva LF Sinani D Bricker H Cook E Doster A Jones C 《Journal of virology》2012,86(5):2459-2473