Cutaneous alternariosis: A rare chromohyphomycosis

A 66-year-old woman presented 3 groups of scaly granulomatous lesions on the right forearm and elbow of six months duration. Direct examination of the scales showed hyphae and culture in lactrimel medium grew Alternaria sp. considered a contaminant. No improvement was observed after six months of treatment with oral griseofulvin. A second culture using half of a biopsy grew Alternaria sp. again and in histologic examination short pigmented fragments of hyphae surrounded by a granulomatous reaction were seen in the derma. The patient had marked improvement after treatment with erythromycin per os and miconazole topically; an atrophic scar remained as the only sign of the fungal infection.     

Cutaneous alternariosis in a liver transplant recipient

We describe the case of a liver transplant patient with a cutaneous alternariosis due to Alternaria infectoria. Cutaneous lesions regressed with the decrease in daily doses of immunosuppressors. The skin lesion remains cicatricial after one year of follow-up.     

Case report: human cutaneous alternariosis

A case of human cutaneous alternariosis caused by Alternaria alternata on the right toe of a man is described and illustrated. Predisposing, debilitating diseases were not detectable. The alternariosis diagnosis was based on the visualization of Alternaria elements in the KOH-preparates and on the repeated successful cultivation of Alternaria alternata. Following local therapy the skin lesion healed.     

大疱性类天疱疮伴发皮肤链格孢病1例

患者,男,70岁。11个月前曾于外院诊断“大疱性类天疱疮”,长期口服“甲泼尼龙和环孢素”治疗。双侧前臂、双手背多发暗红色结节、溃疡半个月余。皮肤溃疡坏死物真菌镜检及培养证实为链格孢菌,经伏立康唑治疗皮损基本痊愈。     

Two new cases of cutaneous alternariosis with a review of the literature

Summary Two cases of cutaneous phaeohyphomycosis due to Alternaria tenuissima in patients affected with primitive myeloproliferative syndrome and lymphocytic lymphoma respectively are reported.Following a review of the specific literature, the authors discuss the etiopathogenic mechanisms, the clinical and histologic aspects of the lesions and the therapeutic problems.     

肺结节病合并Alternaria alternata所致皮肤链格孢病1例

患者,女,61岁,确诊肺结节病、口服糖皮质激素7月,双手背及腕部红色斑块3个月。组织病理示表皮轻度棘层增厚,真皮浅、中层中性粒细胞、淋巴、组织细胞、浆细胞、多核巨细胞混合性浸润,可见散在双轮廓厚壁酵母样结构。六铵银染色见不规则肿胀菌丝及酵母样厚壁孢子。真菌培养见棕/灰褐色菌落,镜下见棕色分隔孢子。ITS区序列分析鉴定为Alternaria alternate。口服伊曲康唑胶囊200 mg/d,联合外用硝酸舍他康唑乳膏2次/d,连续用药4个月后皮损完全消退,随访半年,未见复发。     

皮肤无绿藻病

通过对国内外皮肤无绿藻病的相关文献报道进行分析,总结概括了皮肤无绿藻病的病原学、发病机制、流行病学特点、临床表现及其诊治.     

Cutaneous trichosporosis

Of 269 patients with cutaneous trichosporosis a majority of 170 (63.2%) showed the infection as intertrigo in the genitocrural and perianal areas. The predominant symptoms were itching and burning. Trichosporosis has been found to be less common in the other sites. Trichosporosis due to Trichosporon beigelii should be kept in mind as one of the differential diagnosis in cases of genitocrural intertrigo and other cutaneous infections by fungi and bacteria in the tropics.