共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Adeline Goulet Silvia Spinelli Stéphanie Blangy Herman van Tilbeurgh Nicolas Leulliot Tamara Basta David Prangishvili Christian Cambillau Valérie Campanacci 《Protein science : a publication of the Protein Society》2009,18(6):1316-1320
Acidianus Filamentous Virus 1 (AFV1), isolated from acidic hot springs, is an enveloped lipid‐containing archaeal filamentous virus with a linear double‐stranded DNA genome. It infects Acidianus, which is a hyperthermostable archaea growing at 85°C and acidic pHs, below pH 3. AFV1‐99, a protein of 99 amino acids of unknown function, has homologues in the archaeal virus families Lipothrixviridae and Rudiviridae. We determined the crystal structure of AFV1‐99 at 2.05 Å resolution. AFV1‐99 has a new fold, is hyperthermostable (up to 95°C) and resists to extreme pH (between pH 0 and 11) and to the combination of high temperature (95°C) and low pH (pH 0). It possesses characteristics of hyperthermostable proteins, such as a high content of charged residues. 相似文献
6.
7.
8.
9.
10.
11.
12.
13.
Xiaohong Zhou Zhiyong Lou Sheng Fu Anqi Yang Zexuan Li Mark Bartlam Zihe Rao 《Journal of molecular biology》2010,396(4):1012-1024
14.
15.
16.
17.
18.
19.
20.
A small mobile protein, encoded by the FLOWERING LOCUS T (FT) locus, plays a central role in the control of flowering. FT is regulated positively by CONSTANS (CO), the output of the photoperiod pathway, and negatively by FLC, which integrates the effects of prolonged cold exposure. Here, we reveal the mechanisms of regulation by the microRNA miR172 target SCHLAFMÜTZE (SMZ), a potent repressor of flowering. Whole-genome mapping of SMZ binding sites demonstrates not only direct regulation of FT, but also of many other flowering time regulators acting both upstream and downstream of FT, indicating an important role of miR172 and its targets in fine tuning the flowering response. A role for the miR172/SMZ module as a rheostat in flowering time is further supported by SMZ binding to several other genes encoding miR172 targets. Finally, we show that the action of SMZ is completely dependent on another floral repressor, FLM, providing the first direct connection between two important classes of flowering time regulators, AP2- and MADS-domain proteins. 相似文献