A Comparative Analysis of Nineteenth Century Pharmacopoeias in the Southern United States: A Case Study Based on the Gideon Lincecum Herbarium<Superscript>1</Superscript>

A Comparative Analysis of Nineteenth Century Pharmacopoeias in the Southern United States: A Case Study Based on the Gideon Lincecum Herbarium. The Gideon Lincecum Herbarium represents the pharmacopoeia of Dr. Gideon Lincecum, a botanical physician practicing in Mississippi and Texas during the first half of the nineteenth century. The herbarium contains 313 specimens representing 309 species, 242 genera, and 96 families, and includes ethnobotanical annotations for 286 medicinal taxa. The collection data provided by Lincecum indicate that the specimens were collected between 1835 and 1852. With the exception of 22 specimens considered by Campbell (1951), this is the first study to place this pharmacopoeia in a historical context. Taxonomic determinations of the herbarium specimens were confirmed or corrected. Comparative analyses were conducted to investigate the relationship of Lincecum’s pharmacopoeia to those of six other medical traditions practiced in the southern United States during the nineteenth century. Cluster analyses based on Jaccard co-efficient placed the historical pharmacopoeias of medical traditions in the early nineteenth century into distinct Euro–American and American Indian groups. Despite the recognition of distinct allopathic and botanical medical traditions, an extensive overlap in the composition of their pharmacopoeias is observed. This may reflect the reliance of these traditions on allopathic principles and drugs of plant origin during the first half of the nineteenth century. In contrast, Cherokee, Chickasaw, Choctaw, and Creek pharmacopoeias show limited overlap with each other in composition despite a long history of interaction between these groups. Lincecum’s pharmacopoeia shares a larger Jaccard co–efficient value with the Choctaw pharmacopoeia than would be expected based on their placement in distinct Euro–American and American Indian groups in the dendrogram. The large proportion of Lincecum’s citations that reference Choctaw informants provides direct evidence for the incorporation of Choctaw medical knowledge and taxa into Lincecum’s pharmacopoeia. These data suggest that the composition of historical pharmacopoeias is influenced by both contemporary medical practices and the regional and cultural contexts in which the pharmacopoeias are utilized.     

The way from medical to physiological chemistry at the University of G?ttingen, 1840-1940

In the nineteenth century chemistry was separated from medicine and reorganized as a "pure" academic science. Those left-over parts of chemistry that were more oriented towards medical application formed the nucleus of modern physiological chemistry, but could usually only exist in connection with other subjects. Especially the combination with physiology proved to be stable. Discipline building was delayed by the fact that a lot of physiologists resented a separation from physiology. Also in G?ttingen physiological chemistry was attributed to the Physiological Institute, but initially still had close connections with the General chemical Laboratory. At the end of the nineteenth century a first attempt to establish itself as a discipline together with hygiene failed. Physiological chemistry stayed a part of physiology until 1939 when the Institute of Physiological Chemistry was finally founded. The G?ttingen way is characteristic for the general establishment of the discipline in Germany.     

The origins of medical physics

The historical origins of medical physics are traced from the first use of weighing as a means of monitoring health by Sanctorius in the early seventeenth century to the emergence of radiology, phototherapy and electrotherapy at the end of the nineteenth century. The origins of biomechanics, due to Borelli, and of medical electricity following Musschenbroek's report of the Leyden Jar, are included. Medical physics emerged as a separate academic discipline in France at the time of the Revolution, with Jean Hallé as its first professor. Physiological physics flowered in Germany during the mid-nineteenth century, led by the work of Adolf Fick. The introduction of the term medical physics into English by Neil Arnott failed to accelerate its acceptance in Britain or the USA. Contributions from Newton, Euler, Bernoulli, Nollet, Matteucci, Pelletan, Gavarret, d'Arsonval, Finsen, Röntgen and others are noted. There are many origins of medical physics, stemming from the many intersections between physics and medicine. Overall, the early nineteenth-century definition of medical physics still holds today: ‘Physics applied to the knowledge of the human body, to its preservation and to the cure of its illnesses’.     

The Australian Dominative Medical System: A Reflection of Social Relations in the Larger Society

This paper posits a working or tentative model of medical pluralism, a pattern in which multiple medical sub‐systems co‐exist, or what I term the Australian dominative medical system. I argue that whereas the Australian medical system with its various medical sub‐systems was pluralistic, that is more or less on an equal footing, in the nineteenth century, by the early twentieth century it became a plural or dominative one in the sense that biomedicine came to clearly dominate other medical sub‐systems. This paper also explores the growing interest of biomedicine and the Australian Government in complementary medicine to which Australians have increasingly turned over the course of the past three decades or so.     

Moral medicine: Symbolic content in 19th century Shaker therapeutics

This paper presents an analysis of the symbolic meanings implicit in an ostensibly empirical therapeutic system. The Shakers, a celibate communal religious order founded in New York State in the mid 1770s, were practitioners of botanic medicine, as were many other Americans in the nineteenth century. This study analyzes the therapeutic properties of the herbs they produced (such as diuretic, stimulant, narcotic, emetic, astringent), using a classification scheme based on the location of the botanical substance's effect vis-à-vis body boundaries and surfaces. The Shakers' beliefs about the therapeutic properties of their herbs are compared with similar analyses of the properties given by two contemporary nineteenth century New England proponents of herbal medicine, botanist Constantine Rafinesque and sectarian practitioner Samuel Thomson. The comparison shows systematic variation in emphasis given to herbs which regulate internal body processes, or act through the openings of the body or on its surface. In this context Shaker medicine can be characterized as quickening, internal, and purifying in its effects on body processes, effects which are highly consistent with Shaker religious beliefs in active, physical worship, selflessness and spiritual purification by confession.     

A spirit of scientific rigour: Koch's postulates in twentieth-century medicine

This article explores one of a citation classics in medical literature—Koch's postulates. It analyses their creation in the nineteenth century and their popularity in the twentieth century. As a genre of historiography, references to the postulates are anecdotes. In referring to a historical event that never happened, such references serve to remind their audiences of a tradition of experimental medicine that supposedly originated with Robert Koch.     

Antecedents of ADHD: a historical account of diagnostic concepts

The concept of ADHD has evolved gradually and still carries some traces of its origins. The idea of uncontrolled behaviour as a medical problem arose in eighteenth and nineteenth century accounts. It raised cultural issues about how far control was expected of children. This article traces the development of ideas with particular references to Hoffman's "Struwwelpeter", Frederick Still's "Disorders of Moral Control", minimal brain damage, and the hyperkinetic syndrome.     

The doctrine of specific etiology

Modern medicine is often said to have originated with nineteenth century germ theory, which attributed diseases to bacterial contagions. The success of this theory is often associated with an underlying principle referred to as the “doctrine of specific etiology”. This doctrine refers to specificity at the level of disease causation or etiology. While the importance of this doctrine is frequently emphasized in the philosophical, historical, and medical literature, these sources lack a clear account of the types of specificity that it involves and why exactly they matter. This paper argues that nineteenth century germ theory involves two types of specificity at the level of etiology. One type receives significant attention in the literature, but its influence on modern medicine has been misunderstood. A second type is present in this model, but it has been completely overlooked in the extant literature. My analysis clarifies how these types of specificity led to a novel conception of etiology that continues to figure in medicine today.     

The Tomlinson report and postgraduate medical education.

The postgraduate hospitals of London grew up in the nineteenth century and offered a unique national specialist service. Since then specialist services have developed in undergraduate hospitals throughout Britain as well as in London, but the postgraduate hospitals have nevertheless preserved their high levels of staffing. Although numbers of medical posts in the provinces have grown, this has not been by redistribution of London posts but merely differential growth. The fact identified by Tomlinson--that Londoners are not receiving the most appropriate clinical care--is in fact the strongest argument for changing postgraduate medical education. Such education needs to be rooted first in clinical care, though Tomlinson underestimates the importance to education of such care being sited in a shared environment with strong scientific activity.     

From miasma to asthma: the changing fortunes of medical geography in America

Historians of modern medicine often divide their subject into two parts, separated by the bacteriological revolution of the late nineteenth century, when medicine supposedly became 'scientific' for the first time. The history of medical geography--to say nothing of other subjects--calls this common view into question. At least in the United States, students of medical geography, arguably the pre-eminent medical science in an age dominated by miasmatic theories of disease, readily adapted to the discovery of germs. And although bacteriology quickly eclipsed medical geography in the world of medicine, place remained an important consideration in treating asthma (and allergies generally) throughout the post-bacteriological period.     

A Brief History of the Changing Occupations and Demographics of Coleopterists from the 18th Through the 20th Century

Systematic entomology flourished as a branch of Natural History from the 1750s to the end of the nineteenth century. During this interval, the “era of Heroic Entomology,” the majority of workers in the field were dedicated amateurs. This article traces the demographic and occupational shifts in entomology through this 150-year interval and into the early twentieth century. The survey is based on entomologists who studied beetles (Coleoptera), and who named sufficient numbers of species to have their own names abbreviated by subsequent taxonomists. In the eighteenth century, 27 entomologists achieved this level of prominence, of whom 37% were academics, 19% were doctors, 11% had private incomes, 19% were clergymen, and 8% were government officials. Many of those with private incomes were members of the European aristocracy, and all but one were European men. The nineteenth century list included 192 entomologists, of whom 17% were academics, 16% were museum curators, 2% were school teachers, 15% were doctors, 6% were military men, 7% were merchants, 2% were government entomologists, 6% had private incomes, 5% were clergymen, 5% were government officials, and 4% were lawyers. The demographics of entomology shifted dramatically in the nineteenth century. Whereas many of the noteworthy entomologists of the eighteenth century were German, Swedish, or French, in the nineteenth century, many more European countries are represented, and almost one-fifth of the noteworthy entomologists were from the United States. The nineteenth century list, like the eighteenth century list, contains no women. By the twentieth century, 63% of 178 noteworthy systematic entomologists were paid professionals, teaching entomology courses in universities, or studying insect taxonomy in museums and government-sponsored laboratories. Only one person on the twentieth century list had a private income, but women (ten individuals) were included on the list for the first time.     

Views from the periphery: discourses of race and place in French military medicine

Numerous authors have interpreted the history of anthropological and medical conceptions of race in nineteenth century France as following a path mapped out by phrenology, anthropometry, and Paul Broca's version of physical anthropology. On balance, this has resulted in an historical narrative centered on Parisian intellectual life and one leaving the impression that by the 1890s anthropological theories had moved away from ethnological and cultural explanations toward more biological views of race. This article, by contrast, examines the world beyond Paris and the literatures of naval and army medicine from about 1830 to 1920. It describes the contours of a medical and anthropological pluralism in matters of race and ethnicity and argues that cultural and ethnological perspectives remained important to theorists of race through World War I.     

A comparison between the mandibles of Romano-British and nineteenth century periods

The mandibular and tooth dimensions were measured on a total of 210 specimens from Romano-British, Anglo-Saxon and nineteenth century times. The measurements were subsequently compared by means of univariate and multivariate techniques. The results indicated that the mandibular dimensions decreased more than tooth dimensions between Romano-British and nineteenth century periods, but did not discriminate whether such mandibular changes occurred primarily in the ramus or corpus of the mandible.     

Physiology,Hygiene and the Entry of Women to the Medical Profession in Edinburgh c. 1869–c. 1900

Academic physiology, as it was taught by John Hughes Bennett during the 1870s, involved an understanding of the functions of the human body and the physical laws which governed those functions. This knowledge was perceived to be directly relevant and applicable to clinical practice in terms of maintaining bodily hygiene and human health. The first generation of medical women received their physiological education at Edinburgh University under Bennett, who emphasised the importance of physiology for women due to its relevance for the hygienic needs of the family and of society. With the development of laboratory-based science as a distinct aspect of medical education during the later nineteenth century, however, so the direct application of physiology to clinical practice diminished. The understanding of physiology as hygiene was marginalised by the new orthodoxy of scientific medicine. This shift in the physiological paradigm enabled medical women to stake out a specific field of interest within medicine which was omitted from the new definition of physiology as pure medical science: hygiene and preventive medicine. Women physicians were able to take advantage of the shift towards science as the basis of medical theory and practice to define their own specific role within the profession.     

How to make oneself nature's spokesman? A latourian account of classification in eighteenth- and early nineteenth-century natural history

Classification in eighteenth-century natural history was marked by a battle of systems. The Linnaean approach to classification was severely criticized by those naturalists who aspired to a truly natural system. But how to make oneself nature's spokesman? In this article I seek to answer that question using the approach of the French anthropologist of science Bruno Latour in a discussion of the work of the French naturalists Buffon and Cuvier in the eighteenth and early nineteenth century. These naturalists followed very different strategies in creating and defending of what they believed to be a natural classification in zoology. Buffon failed, whereas Cuvier's work appeared to be very successful. My argument will be that, to explain Buffon's failure and Cuvier's success, we should not focus on the epistemological or theoretical concerns and justifications of these naturalists, but on the concrete and heterogeneous means or tools through which animals were mobilized, stabilized and combined into ever more comprehensive systems of classification.     

Consumption, silicosis, and the social construction of industrial disease.

In the wake of the bacterial revolution after Robert Koch identified the tuberculosis bacillus, medical and public health professionals classified the various forms of consumption and phthisis as a single disease--tuberculosis. In large measure, historians have adopted that perspective. While there is undoubtedly a great deal of truth in this conceptualization, we argue that it obscures almost as much as it illuminates. By collapsing the nineteenth-century terms phthisis and consumption into tuberculosis, we maintain that historians have not understood the effect of non-bacterial consumption on working-class populations who suffered from the symptoms of coughing, wasting away, and losing weight. In this essay, we explore how, in the nineteenth century, what we now recognize as silicosis was referred to as miners' "con," stonecutters' phthisis, and other industry-specific forms of phthisis and consumption. We examine how the later and narrower view of the bacterial origins of tuberculosis limited the medical professions' ability to diagnose and understand diseases caused by industrial dust. This paper explores the contention that developed at the turn of the century over occupational lung disease and tuberculosis and the circumstances that led to the unmasking of silicosis as a disease category.     

Did the mean height of Australian-born men decline in the late nineteenth century? A comment

Using military and prisoner measurements, a number of scholars have concluded that there was a decline of the mean height of Australian-born men in the late nineteenth century. This paper offers an evaluation of these studies and suggests that further research is needed to determine the Australian height trend in the late nineteenth century.     

Alcohol and heredity: Theories about the effects of alcohol use on offspring

Abstract

Medical temperance writers throughout the nineteenth century and well into the first two decades of the twentieth century argued that alcohol use by parents caused hereditary disease in their offspring. In particular, it was believed that alcohol use was responsible for feeblemindedness, epilepsy, and various other nervous system disorders. In 1910, Karl Pearson and his associates at the Galton Eugenics Laboratory of the University of London published a statistical study seriously challenging the view that alcohol use was causally related to heritable disease in offspring. Although the study generated considerable controversy and had certain flaws by contemporary standards, the weight of the evidence was sufficient to discredit the theories of the medical temperance writers.     

Homeostasis and the physiological dimension of niche construction theory in ecology and evolution

Niche construction theory (NCT) has been represented as a new and comprehensive theory of evolution, one that breaks the constraints imposed by the dominant and largely gene-selectionist standard evolutionary model that is presently mischaracterized as “Darwinian.” I will argue that NCT is not so much a new theory, as it is a fruitful readmission of a venerable physiological perspective on adaptation, selection and evolution. This perspective is closer in spirit and philosophy to the original (and richer) Darwinian idea developed by Darwin himself, and that animated much of the rich late nineteenth century debate about evolution, heredity, adaptation and development, a debate that was largely eclipsed by the early twentieth century emergence of the Neodarwinian synthesis. I will argue that a full realization of the promise of NCT turns on a full understanding of another intellectual revolution of the nineteenth century, Claude Bernard’s conception of homeostasis, a profound statement of the nature of life that has, through the twentieth century, come to be widely misunderstood and trivialized.