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1.
Bingi VN 《Biofizika》2000,45(4):757-759
The interference mechanism for biological reception of weak magnetic fields was studied with consideration for the own molecular rotations of ion-protein complexes. An additional rotation of a biological system is shown to decrease the biological effect of "magnetic vacuum" and split spectral peaks from the effects of static magnetic field. 相似文献
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The fundamental physical mechanisms of resonance action of an extremely weak (40 nT) alternating magnetic field at the cyclotron frequency combined with a weak (40 μT) static magnetic field, on living systems are analyzed in the present work. The experimental effects of such sort of magnetic fields were described in different papers: the very narrow resonant peaks in electrical conductivity of the aqueous solutions in the in vitro experiments and the biomedical in vivo effects on living animals of magnetic fields with frequencies tuned to some amino acids. The existing experimental in vitro data had a good repeatability in different laboratories and countries. Unfortunately, for free ions such sort of effects are absolutely impossible because the dimensions of an ion rotation radius should be measured by meters at room temperature and at very low static magnetic fields used in all the above experiments. Even for bound ions these effects should be also absolutely impossible from the positions of classic physics because of rather high viscosity of biological liquid media (blood plasma, cerebrospinal liquid, cytoplasm). Only modern quantum electrodynamics of condensed media opens the new ways for solving these problems. The proposed article is devoted to analysis of quantum mechanisms of these effects. 相似文献
3.
The effect of week static magnetic fields on Escherichia coli K12 AB1157 cells was studied by the method of anomalous viscosity time dependencies (AVTD). The AVTD changes were found when E. coli cells were exposed to static fields within the range from 0 to 110 microT. The dependence of the effect on the magnetic flux density had several extrema. These results were compared with theoretical predictions of the ion interference mechanism. This mechanism links the dissociation probability of ion--protein complexes to parameters of magnetic fields. The mechanism was extended to the case of rotating complexes. Calculations were made for several ions of biological relevance. The results of simulations for Ca(2+), Mg(2+), and Zn(2+) showed a remarkable consistency with experimental data. An important condition for this consistency was that all complexes rotate with the same speed approximately 18 revolutions per second (rps). This suggests that the rotation of the same carrier for all ion--protein complexes may be involved in the mechanism of response to the magnetic field. We believe that this carrier is DNA. 相似文献
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Santana RC Cunha RO Carvalho JF Vencato I Calvo R 《Journal of inorganic biochemistry》2005,99(2):415-423
We report EPR measurements at 9.77 and 34.1 GHz in powder and single crystal samples of the ternary copper amino acid complex Cu(L-arginine)(2)(SO(4)).(H(2)O)(6). The single crystal Electron Paramagnetic Resonance spectra display a single resonance for all magnetic field orientations in the ca and cb crystal planes. In the ab plane they display two resonances for most orientations of the magnetic field, and only one resonance for orientations close to the crystal axes. This behavior is a result of the selective collapse of the resonances corresponding to the four copper sites in the unit cell produced by the exchange interactions between copper ions. From the characteristics of the collapse and the angular dependences of the position and width of the resonances we evaluate the g-tensors of the copper molecules and estimate exchange interactions |J(1)/k(B)|=0.9 K and |J(2)/k(B)|=0.009 K between copper neighbors at 5.908 A and at 15.684 A, respectively. J(1) is assigned to a syn-anti equatorial-apical carboxylate bridge with a total bond length of 7.133 A. J(2) is assigned to a long bridge of 12 atoms with a total bond length of 19.789 A, that includes two hydrogen bonds. The results are discussed in terms of the crystal and electronic structure of Cu(L-arginine)(2)(SO(4)).(H(2)O)(6). We show that J(2) is in excellent agreement with the observed magnetic interaction between the reduced quinone acceptors in the photosynthetic reaction center protein of the bacterium Rb. sphaeroides, which is transmitted along a similar chemical path containing two hydrogen bonds. Our findings indicate that it is valid to estimate values for the exchange interactions between redox centers in proteins transmitted along long chemical paths containing sigma and H-bonds, from data obtained in model systems, and emphasize the importance of measuring exchange interactions in biologically relevant model systems. 相似文献
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Many in vitro experiments on the biological effects of extremely low frequency (ELF) electromagnetic fields utilize a uniform external magnetic flux density (B) to expose biological materials. A significant number of researchers do not measure or estimate the resulting electric field strength (E) or current density (J) in the sample medium. The magnitude and spatial distribution of the induced E field are highly dependent on the sample geometry and its relative orientation with respect to the magnetic field. We have studied the E fields induced in several of the most frequently used laboratory culture dishes and flasks under various exposure conditions. Measurements and calculations of the E field distributions in the aqueous sample volume in the containers were performed, and a set of simple, quantitative tables was developed. These tables allow a biological researcher to determine, in a straightforward fashion, the magnitudes and distributions of the electric fields that are induced in the aqueous sample when it is subjected to a uniform, sinusoidal magnetic field of known strength and frequency. In addition, we present a novel exposure technique based on a standard organ culture dish containing two circular, concentric annular rings. Exposure of the organ culture dish to a uniform magnetic field induces different average electric fields in the liquid medium in the inner and outer rings. Results of experiments with this system, which were reported in a separate paper, have shown the dominant role of the magnetically induced E field in producing specific biological effects on cells, in vitro. These results emphasize the need to report data about the induced E field in ELF in-vitro studies, involving magnetic field exposures. Our data tables on E and J in standard containers provide simple means to enable determination of these parameters. 相似文献
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The coupled rotational dynamics of the m/n = 2/1 and 3/2 MHD modes in an ohmic discharge and the m/n = 2/1 and 4/1 modes in a regime with on-axis electron-cyclotron resonance heating were studied experimentally. The specific features of rotation of these modes in the presence of an error magnetic field, in particular the dependence of the instantaneous frequency Ω(t) of the MHD mode on its spatial orientation at the current instant, were revealed. In analyzing the results obtained, MHD modes were identified with tearing modes (magnetic islands) having a corresponding spatial structure. A possible mechanism for the mutual influence of magnetic islands resulting in their consistent rotation is discussed. 相似文献
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Low-intensity magnetic fields alter operant behavior in rats 总被引:1,自引:0,他引:1
The present study demonstrates that operant behavior is affected by a combination of a 60-Hz magnetic field and a magnetostatic field 2.6 X 10(-5) T (about half the geomagnetic field). Rats exposed to this combination for 30 min consistently exhibited changes in the rate and pattern of responding during the differential reinforcement of low rate (DRL) component of a multiple fixed ratio (FR) DRL reinforcement schedule. By contrast, there were no measurable changes following exposure to the static field alone or to the oscillating field alone, even with a 10-fold increase in intensity (5 X 10(-5) to 5 X 10(-4) Trms). A cyclotron resonance mechanism has been suggested as a possible explanation for the observation that weak static magnetic fields modify the response of in vitro brain tissue to low-frequency magnetic fields. The choice of static field intensity Bo and frequency nu in the present study follows from the cyclotron resonance condition nu = (1/2 pi)(q/m)Bo, for singly charged lithium, an element in extensive use in the clinical treatment of affective disorders in humans. The present research is consistent with a cellular cyclotron resonance mechanism and tends to imply a functional dependence of behavior on the geomagnetic field. 相似文献
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Possible mechanism for the influence of weak magnetic fields on biological systems 总被引:11,自引:0,他引:11
V V Lednev 《Bioelectromagnetics》1991,12(2):71-75
A physical mechanism is suggested for a resonant interaction of weak magnetic fields with biological systems. An ion inside a Ca(2+)-binding protein is approximated by a charged oscillator. A shift in the probability of ion transition between different vibrational energy levels occurs when a combination of static and alternating magnetic fields is applied. This in turn affects the interaction of the ion with the surrounding ligands. The effect reaches its maximum when the frequency of the alternating field is equal to the cyclotron frequency of this ion or to some of its harmonics or sub-harmonics. A resonant response of the biosystem to the magnetic field results. The proposed theory permits a quantitative explanation for the main characteristics of experimentally observed effects. 相似文献
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Comparatively high exposures to power-frequency electric and magnetic fields produce established biological effects that are explained by accepted mechanisms and that form the basis of exposure guidelines. Lower exposures to magnetic fields (< 1 microT average in the home) are classified as "possibly carcinogenic" on the basis of epidemiological studies of childhood leukemia. This classification takes into consideration largely negative laboratory data. Lack of biophysical mechanisms operating at such low levels also argues against causality. We survey around 20 biophysical mechanisms that have been proposed to explain effects at such low levels, with particular emphasis on plausibility: the principle that to produce biological effects, a mechanism must produce a "signal" larger than the "noise" that exists naturally. Some of the mechanisms are impossible, and some require specific conditions for which there is limited or no evidence as to their existence in a way that would make them relevant to human exposure. Others are predicted to become plausible above some level of field. We conclude that effects below 5 microT are implausible. At about 50 microT, no specific mechanism has been identified, but the basic problem of implausibility is removed. Above about 500 microT, there are established or likely effects from accepted mechanisms. The absence of a plausible biophysical mechanism at lower fields cannot be taken as proof that health effects of environmental electric and magnetic fields are impossible. Nevertheless, it is a relevant consideration in assessing the overall evidence on these fields. 相似文献
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We have investigated the effects of magnetic fields on the formation and decay of excited states in the photochemical reaction centers of Rhodopseudomonae sphaeroides. In chemically reduced reaction centers, a magnetic field decreases the fraction of the transient state PF that decays by way of the bacteriochlorophyll triplet state PR. At room temperature, a 2-kG field decreases the quantum yield of Pr by about 40%. In carotenoid-containing reaction centers, the yield of the carotenoid triplet state which forms via PR is reduced similarly. The effect of the field depends monotonically on field-strength, saturating at about 1 kG. The effect decreases at lower temperatures, when the yield of PR is higher. Magnetic fields do not significantly affect the formation of the triplet state of bacteriochlorophyll in vitro, the photooxidation of P870 in reaction centers at moderate redox potential, or the decay kinetics of states PF and PR. The effect of magnetic fields support in view that state PF is a radical pair which is born in a singlet state but undergoes a rapid transformation into a mixture of singlet and triplet states. A simple kinetic model can account for the effects of the field and relate them to the temperature dependence of the yield of PR. 相似文献
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Possible mechanisms of action of weak combined magnetic fields on biological systems have been discussed in terms of quantum mechanics. The approaches proposed make it possible to solve the problem of the failure to compare the energy of active factors with the energy of thermal motion (kT problem). A mechanism of action of combined magnetic fields on biosystems has been proposed. 相似文献
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A. H. Jafary-Asl S. N. Solanki E. Aarholt C. W. Smith 《Journal of biological physics》1983,11(1):15-22
In the course of work on the interactions of electric and magnetic fields with both living and dead biological materials, it was noticed that certain published dielectrophoretic yield curves for biological cells showed unexplained deviations in the region of 2 kHz. Dielectrophoretic measurements made at frequencies and magnetic fields which satisfied the nuclear magnetic resonance conditions showed sharply resonant features. Dielectric measurements showed small, but sharp, resonances most easily seen in the dielectric loss curves which had a bandwidth of the order of one Hertz and presented at the frequencies which satisfied the magnetic resonance conditions for the ambient magnetic field. Resonances were found corresponding to the frequencies for electron spin resonance and nuclear magnetic resonance for1H,31P,23Na,37Cl and39K. The onset of these resonances occurs at the value of the steady magnetic field strength so that one quantum of magnetic flux (2.07×10?15wb) would link a single biological cell or pair of cells, approximately 1 G (100μT) in the case of a 5-μm yeast cell. The effects of these magnetic resonance conditions on the mean generation time ofE. coli and on the reaction of the enzyme lysozyme with the substrateM. lysodeikticus cells are also shown. 相似文献
16.
《Biophysical journal》2020,118(3):578-585
Despite the importance of magnetic properties of biological samples for biomagnetism and related fields, the exact magnetic susceptibilities of most biological samples in their physiological conditions are still unknown. Here we used superconducting quantum interferometer device to detect the magnetic properties of nonfixed, nondehydrated live cell and cellular fractions at a physiological temperature of 37°C (310 K). It is obvious that there are paramagnetic components within human nasopharyngeal carcinoma CNE-2Z cells. More importantly, the magnetic properties of the cytoplasm and nucleus are different. Although within a single cell, the magnetic susceptibility difference between cellular fractions (nucleus and cytoplasm) could only cause ∼41–130 pN forces to the nucleus by gradient ultrahigh magnetic fields of 13.1–23.5 T (92–160 T/m), these forces are enough to cause a relative position shift of the nucleus within the cell. This not only demonstrates the importance of magnetic susceptibility in the biological effects of magnetic field but also illustrates the potential application of high magnetic fields in biomedicine. 相似文献
17.
The literature about the biological effects of magnetic fields is reviewed. We begin by discussing the weak and/or time variable fields, responsible for subtle changes in the circadian rhythms of superior animals, which are believed to be induced by same sort of "resonant mechanism". The safety issues related with the strong magnetic fields and gradients generated by clinical NMR magnets are then considered. The last portion summarizes the debate about the biological effects of strong and uniform magnetic fields. 相似文献
18.
Possible mechanisms of action of weak combined magnetic fields on biological systems have been discussed in terms of quantum
mechanics. The approaches proposed make it possible to solve the problem of the failure to compare the energy of active factors
with the energy of thermal motion (kT problem). A mechanism of action of combined magnetic fields on biosystems has been proposed. 相似文献
19.
The production of ATP in mitochondria depends on the magnesium nuclear spin and magnetic moment of a Mg2+ ion in creatine kinase and ATPase. This suggests that enzymatic synthesis of ATP is an ion-radical process and thus depends on the external magnetic field (magnetobiology originates from this fact) and microwave fields, which control the spin states of ion-radical pairs and affect the ATP synthesis. The chemical mechanism of ATP synthesis and the origin of biological effects of electromagnetic (microwave) fields are discussed. 相似文献
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ATP production in mitochondria depends on the nuclear spin and magnetic moment of Mg2+ ion in creatine kinase and ATPase. Consequently, the enzymatic synthesis of ATP is an ion-radical process and depends on the external magnetic field and microwave fields that control the spin states of ion-radical pairs and influence the ATP synthesis. The chemical mechanism of ATP synthesis and the origin of biological effects of electromagnetic (microwave) fields are discussed. 相似文献