共查询到20条相似文献,搜索用时 15 毫秒
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W Januszewicz B Wocial J Chodakowska T Feltynowski M Lapiński 《Polski tygodnik lekarski (Warsaw, Poland : 1960)》1991,46(35-36):658-659
An effect of calcium antagonist-isradipine-on catecholamines and their metabolites excretion with the urine in 4 patients with pheochromocytoma has been analysed. It was found that the excretion of OFFnoradrenaline and vanilaminomandelic acid is reduced. It may indicate inhibitory effect of calcium antagonists on catecholamines secretion in patients with pheochromocytoma. 相似文献
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J Juchmes N Van Liefferinge J Lecomte 《Comptes rendus des séances de la Société de biologie et de ses filiales》1977,171(6):1309-1312
Normal man submitted to thermoneutral water immersion in horizontal position presents an increase in diuresis, natriuresis and creatininuria. Noradrenalinuria and adrenalinuria are reduced, indicating a decrease in orthosympathetic activity. 相似文献
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A Cession-Fossion M Staiesse J Lecomte 《Comptes rendus des séances de la Société de biologie et de ses filiales》1977,171(6):1313-1316
The urinary excretion of noradrenaline, adrenaline and creatinine has been studied in 22 normal young men during a sauna bath (20 minutes). The radio noradrenalinuria/creatinine is specifically increased, indicating a stimulation of the orthosympathetic system (19.6 ng.mg-1 +/- 7.9 in basal state; 30.5 +/- 15.7 in sauna bath). 相似文献
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Silvestro Suraniti Françoise Bled Andrée Girault Philippe Fressinaud Michel Marre 《Molecular and cellular biochemistry》1992,109(2):197-200
The increase of urinary albumin excretion has a predictive value for cardiovascular disease in insulin-dependent and non insulin-dependent diabetics. To study the relationship between urinary albumin excretion and serum lipids, 380 non insulin-dependent diabetics, 40 to 75 yr old, with urinary albumin excretion from 0 to 200 mg/l, and normal serum creatinine (less than 150 µmol/1), were surveyed. Urinary albumin excretion, was related positively to age (r2 = 0.014; p = 0.02), to systolic blood pressure (r2 = 0.073, p = 0.0001) and diastolic blood pressure (r2 = 0.052, p = 0.0001); a negative correlation existed with HDL-cholesterol (r2 = 0.043, p = 0.0001) and Apoprotein A1 (r2 = 0.044, p = 0.0001). A stepwise regression analysis was performed and resulted in three independently contributing variables related to urinary albumin excretion: First systolic blood pressure (F = 36), second Apoprotein A1 (F 24), third hemoglobin AlC (F = 6). The presence of hypertension or insulin therapy did not modify these findings. In conclusion, serum lipid seems an important determinant of urinary albumin excretion in non insulin-dependent diabetics.Abbreviations UAE
Urinary Albumin Excretion
- IDDs
Insulin-Dependent Diabetics
- NIDDs
Non Insulin-Dependent Diabetics
- ACE
Angiotensin-converting-enzyme
- HDL
High Density Lipoproteins
- VLDL
Very Low Density Lipoproteins
- LDL
Low Density Lipoproteins 相似文献
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A Lapolla R Reitano L Baccarin G Sartore M Plebani D Fedele 《Hormones et métabolisme》2005,37(4):252-256
Levels of plasma pentosidine, a well-known AGE, were measured in type 2 diabetic patients in varying states of metabolic control to verify possible relationships between this parameter and traditional metabolic control parameters such as HbA1c and plasma glucose levels. At baseline, mean values of fasting plasma glucose, HbA1c and pentosidine were significantly higher in diabetic patients than those of controls, confirming patients' poor glycemic control. After ten months, patients with good metabolic control achieved showed near-normal HbA1c levels and reduced but not normalized pentosidine levels. Significant differences were found in the mean percentage decrease in the parameters. Regarding linear correlation, HbA1c levels only showed a positive relationship with plasma glucose values at baseline. Patients affected by chronic complications showed higher levels of pentosidine than those without complications. Thus, pentosidine plasma levels may be used to evaluate very long-term metabolic control in diabetic patients. In addition, a period of ten months of acceptable metabolic control is not enough to normalize pentosidine levels in diabetics, thus emphasizing the need for a longer period of improved metabolic control to reduce both this parameter and the burden of chronic diabetic complications. 相似文献
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J J Kabara R M Riggin P T Kissinger 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1976,151(1):168-172
Twenty-four-hour urine was collected from normal and dystrophic mice and hamsters for catecholamine determinations. A new method of analysis was used whereby 3,4-dihydroxyphenylalanine (DOPA), dopamine (DA), norepinephrine (NE), and epinephrine (E) were measured simultaneously. The procedure is based on a combination of liquid-solid extraction, cation exchange chromatography, and controlled potential electrochemistry. The results of these experiments indicated that while DA levels were similar in both normal and pathological animal urine, DOPA levels decreased slightly in the dystrophic mouse but not the hamster, and NE and E levels in dystrophic groups were two and four times greater than normal in both species. The data supports the concept of biochemical alterations in tissue other than muscle. While not necessarily supportive to catecholamine abnormality as the primary cause of muscular dystrophy, the present data cast doubt that this disease is a primary muscle disease. 相似文献
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Oguogho A Ferlitsch A Sinzinger H 《Prostaglandins, leukotrienes, and essential fatty acids》2000,62(4):209-216
Isoprostanes (IP) generated during free radical catalyzed oxidation injury have been claimed as a reliable indicator of oxidative stress in vivo. In particular, they are formed during LDL-oxidation. Vascular content, plasma levels and urinary excretion of IP were reported to be elevated in hypercholesterolemia. We therefore assessed the values of the IP 8-epi-PGF2alpha in plasma and urine in nine patients (7 males, 2 females) suffering from severe heterozygous hypercholesterolemia before and after LDL-apheresis as well as during the interval. LDL-apheresis caused a significant (P<0.01) drop in 8-epi-PGF2alpha in plasma and urine. The respective values in smokers (n = 4) were significantly (P<0.01) higher as compared to non-smokers. No sex difference was seen. Together with the findings of a parallel decrease in oxidized LDL, these data show a significant benefit of LDL-apheresis reducing in vivo oxidation injury. This benefit may at least partly contribute to the clinical improvement seen in the patients treated. 相似文献
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We examined the specificity of tyrosine's ability to increase catecholamine excretion by rats. Tyrosine alone among amino acids tested caused major increases in tissue and serum tyrosine, as well as urinary catecholamine levels. Large neutral amino acids (tryptophan, valine or isoleucine) and representatives of other classes of amino acids (glutamate, alanine, lysine or arginine) were unable to mimic tyrosine's action. 相似文献
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Elevated plasma levels of asymmetric dimethylarginine (ADMA) inhibit nitric oxide formation and exert a proatherogenic action. Low testosterone (T) levels are associated with increased cardiovascular risks. This study analyzed the effects of normalization of plasma T levels on plasma levels and urinary excretion of ADMA in hypgonadal men (n=10) receiving transdermal T administration. Plasma T levels, starting from clearly hypogonadal T plasma concentrations with a mean level of 4.0+/-2.72 nmol/l at baseline, rose to >10 nmol/l after 2 weeks, with plasma T levels within the normal range of men (mean level of 22.5+/-11.3 nmol/l) over the last 16 weeks of the 24 weeks of T administration. Normalization of plasma T led to a small but significant fall of plasma ADMA (519+/-55 vs. 472+/-59 nmol/l, p=0.031). The outcome of this study may be viewed as a favorable effect of normalization of plasma testosterone on plasma ADMA since even small elevations of plasma ADMA significantly increase cardiovascular risk. While this effect of normalization of plasma T may impress as favorable, most available studies on effects of T administration to hypogonadal men have not shown beneficial effects on functions of the vascular wall. 相似文献
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