共查询到20条相似文献,搜索用时 140 毫秒
1.
Background
Microarray technology allows simultaneous measurement of thousands of genes in a single experiment. This is a potentially useful tool for evaluating co-expression of genes and extraction of useful functional and chromosomal structural information about genes. 相似文献2.
Chia-Huei Lee Chih-Min Liu Chun-Chiang Wen Shun-Min Chang Hai-Gwo Hwu 《Journal of biomedical science》2010,17(1):2
Background
Schizophrenia is a complex disorder with involvement of multiple genes. 相似文献3.
Alan Villalobos Jon E Ness Claes Gustafsson Jeremy Minshull Sridhar Govindarajan 《BMC bioinformatics》2006,7(1):285-8
Background
Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi resistant genes and protein engineering. Here we introduce a software tool that drastically facilitates the design of synthetic genes. 相似文献4.
Background
Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws. However, for many outcrossing species, such pedigrees are not available and genes also display population properties. 相似文献5.
Alexander Y Panchin Mikhail S Gelfand Vasily E Ramensky Irena I Artamonova 《Biology direct》2010,5(1):54
Background
Gene duplications are a source of new genes and protein functions. The innovative role of duplication events makes families of paralogous genes an interesting target for studies in evolutionary biology. Here we study global trends in the evolution of human genes that resulted from recent duplications. 相似文献6.
Mark TA Donoghue Channa Keshavaiah Sandesh H Swamidatta Charles Spillane 《BMC evolutionary biology》2011,11(1):47
Background
All sequenced genomes contain a proportion of lineage-specific genes, which exhibit no sequence similarity to any genes outside the lineage. Despite their prevalence, the origins and functions of most lineage-specific genes remain largely unknown. As more genomes are sequenced opportunities for understanding evolutionary origins and functions of lineage-specific genes are increasing. 相似文献7.
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Nuno A Fonseca Cristina P Vieira Peter WH Holland Jorge Vieira 《BMC evolutionary biology》2008,8(1):200
Background
Although homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes. 相似文献9.
Mariana Conte Silvia de Simone Susan J Simmons Carlos L Ballaré Ann E Stapleton 《BMC plant biology》2010,10(1):112
Background
Understanding of the genetic architecture of plant UV-B responses allows extensive targeted testing of candidate genes or regions, along with combinations of those genes, for placement in metabolic or signal transduction pathways. 相似文献10.
Gene selection algorithms for microarray data based on least squares support vector machine 总被引:1,自引:0,他引:1
Background
In discriminant analysis of microarray data, usually a small number of samples are expressed by a large number of genes. It is not only difficult but also unnecessary to conduct the discriminant analysis with all the genes. Hence, gene selection is usually performed to select important genes. 相似文献11.
Background
Microarray technology is commonly used as a simple screening tool with a focus on selecting genes that exhibit extremely large differential expressions between different phenotypes. It lacks the ability to select genes that change their relationships with other genes in different biological conditions (differentially correlated genes). We intend to enrich the above procedure by proposing a nonparametric selection procedure that selects differentially correlated genes. 相似文献12.
Background
The metastatic ability of tumor cells is determined by level of expression of specific genes that may be identified with the aid of cDNA microarray containing thousands of genes and can be used to establish the expression profile of disease related genes in complex biological system. 相似文献13.
Background
Microarray experiments, as well as other genomic analyses, often result in large gene sets containing up to several hundred genes. The biological significance of such sets of genes is, usually, not readily apparent. 相似文献14.
Background
Overlapped genes originate by a) loss of a stop codon among contiguous genes coded in different frames; b) shift to an upstream initiation codon of one of the contiguous genes; or c) by overprinting, whereby a novel open reading frame originates through point mutation inside an existing gene. Although overlapped genes are common in viruses, it is not clear whether overprinting has led to new genes in prokaryotes. 相似文献15.
Background
One of the important goals of microarray research is the identification of genes whose expression is considerably higher or lower in some tissues than in others. We would like to have ways of identifying such tissue-specific genes. 相似文献16.
Background
Identifying essential genes in bacteria supports to identify potential drug targets and an understanding of minimal requirements for a synthetic cell. However, experimentally assaying the essentiality of their coding genes is resource intensive and not feasible for all bacterial organisms, in particular if they are infective. 相似文献17.
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Barbara Hutter Matthias Bieg Volkhard Helms Martina Paulsen 《BMC evolutionary biology》2010,10(1):116
Background
In contrast to the majority of mammalian genes, imprinted genes are monoallelically expressed with the choice of the active allele depending on its parental origin. Due to their special inheritance patterns, maternally and paternally expressed genes might be under different evolutionary pressure. Here, we aimed at assessing the evolutionary history of imprinted genes. 相似文献20.