共查询到20条相似文献,搜索用时 31 毫秒
1.
Yi Peng Hong Shi Xue-bin Qi Chun-jie Xiao Hua Zhong Run-lin Z Ma Bing Su 《BMC evolutionary biology》2010,10(1):15
Background
The emergence of agriculture about 10,000 years ago marks a dramatic change in human evolutionary history. The diet shift in agriculture societies might have a great impact on the genetic makeup of Neolithic human populations. The regionally restricted enrichment of the class I alcohol dehydrogenase sequence polymorphism (ADH1BArg47His) in southern China and the adjacent areas suggests Darwinian positive selection on this genetic locus during Neolithic time though the driving force is yet to be disclosed. 相似文献2.
Background
There is legitimate concern that minority drug-resistant mutants may be selected during the initial HIV-1 RNA decay phase following antiretroviral therapy initiation, thus undermining efficacy of treatment. The goal of this study was to characterize viral resistance emergence and address viral population evolution during the first phase of viral decay after treatment containing initiation.Findings
454 sequencing was used to characterize viral genetic diversity and polymorphism composition of the HIV-1 integrase gene during the first two weeks following initiation of raltegravir-containing HAART in four ART-experienced subjects. No low-prevalence Raltegravir (RAL) drug resistance mutations (DRM) were found at baseline. All patients undergoing treatment received a fully active ART according to GSS values (GSS?≥?3.5). No emergence of DRM after treatment initiation was detected. Longitudinal analysis showed no evidence of any other polymorphic mutation emergence or variation in viral diversity indexes.Conclusions
This suggests that fully active salvage antiretroviral therapy including raltegravir achieves a complete blockade of HIV-1 replication in plasma. It is unlikely that raltegravir-resistant HIV-1 may be selected in plasma during the early HIV-1 RNA decay after treatment initiation if the administered therapy is active enough.3.
Ignacio Marín 《BMC evolutionary biology》2009,9(1):267
Background
Cullins are proteins involved in ubiquitination through their participation in multisubunit ubiquitin ligase complexes. In this study, I use comparative genomic data to establish the pattern of emergence and diversification of cullins in eukaryotes. 相似文献4.
Background
There is an increasing need for computer-generated models that can be used for explaining the emergence and predicting the behavior of multi-protein dynamic structures in cells. Multi-agent systems (MAS) have been proposed as good candidates to achieve this goal. 相似文献5.
Background
The HIV virus is known for its ability to exploit numerous genetic and evolutionary mechanisms to ensure its proliferation, among them, high replication, mutation and recombination rates. Sliding MinPD, a recently introduced computational method [1], was used to investigate the patterns of evolution of serially-sampled HIV-1 sequence data from eight patients with a special focus on the emergence of X4 strains. Unlike other phylogenetic methods, Sliding MinPD combines distance-based inference with a nonparametric bootstrap procedure and automated recombination detection to reconstruct the evolutionary history of longitudinal sequence data. We present serial evolutionary networks as a longitudinal representation of the mutational pathways of a viral population in a within-host environment. The longitudinal representation of the evolutionary networks was complemented with charts of clinical markers to facilitate correlation analysis between pertinent clinical information and the evolutionary relationships. 相似文献6.
Eleanor I Ager Andrew J Pask Helen M Gehring Geoff Shaw Marilyn B Renfree 《BMC evolutionary biology》2008,8(1):163
Background
Genomic imprinting occurs in both marsupial and eutherian mammals. The CDKN1C and IGF2 genes are both imprinted and syntenic in the mouse and human, but in marsupials only IGF2 is imprinted. This study examines the evolution of features that, in eutherians, regulate CDKN1C imprinting. 相似文献7.
Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation,decapping and RNA stability 总被引:2,自引:0,他引:2
Background
The emergence of eukaryotes was characterized by the expansion and diversification of several ancient RNA-binding domains and the apparentde novoinnovation of new RNA-binding domains. The identification of these RNA-binding domains may throw light on the emergence of eukaryote-specific systems of RNA metabolism. 相似文献8.
Background
The emergence of structural genomics presents significant challenges in the annotation of biologically uncharacterized proteins. Unfortunately, our ability to analyze these proteins is restricted by the limited catalog of known molecular functions and their associated 3D motifs. 相似文献9.
Levent Kart Remzi Altın Meltem Tor Inci Gulmez Sema F Oymak Hulusi M Atmaca Funda Erdem 《Annals of clinical microbiology and antimicrobials》2002,1(1):6-5
Backround
The emergence of Mycobacterium tuberculosis strains resistant to antituberculosis agents has recently received increased attention owing largely to the dramatic outbreaks of multi drug resistance tuberculosis (MDR-TB). 相似文献10.
Tanja Schneegans Uwe Borgmeyer Moritz Hentschke Richard M Gronostajski Melitta Schachner Thomas Tilling 《BMC molecular biology》2009,10(1):107
Background
The neural cell adhesion molecule L1 plays a crucial role in development and plasticity of the nervous system. Neural cells thus require precise control of L1 expression. 相似文献11.
N Henning Zai? Maja Rupnik Ed J Kuijper Celine Harmanus Dolf Michielsen Koen Janssens Ulrich Nübel 《BMC microbiology》2009,9(1):6
Background
Genotyping of epidemic Clostridium difficile strains is necessary to track their emergence and spread. Portability of genotyping data is desirable to facilitate inter-laboratory comparisons and epidemiological studies. 相似文献12.
Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes 总被引:1,自引:0,他引:1
Background
Human enterovirus 71 (EV-71) is a common causative agent of hand, foot and mouth disease (HFMD). In recent years, the virus has caused several outbreaks with high numbers of deaths and severe neurological complications. Several new EV-71 subgenotypes were identified from these outbreaks. The mechanisms that contributed to the emergence of these subgenotypes are unknown. 相似文献13.
Philippe Cottagnoud Jose M Entenza Marianne Cottagnoud Yok-Ai Que Philippe Moreillon Martin G Täuber 《BMC microbiology》2001,1(1):9-4
Background
The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emergence of quinolone resistance. 相似文献14.
Igor A Valouev Gleb V Fominov Elizaveta E Sokolova Vladimir N Smirnov Michael D Ter-Avanesyan 《BMC molecular biology》2009,10(1):60-13
Background
Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRF1 and eRF3. While eRF1 recognizes nonsense codons, eRF3 facilitates polypeptide chain release from the ribosome in a GTP-dependent manner. Besides termination, both release factors have essential, but poorly characterized functions outside of translation. 相似文献15.
Xiulin Han Angella Dorsey-Oresto Muhammad Malik Jian-Ying Wang Karl Drlica Xilin Zhao Tao Lu 《BMC microbiology》2010,10(1):35
Background
The continuing emergence of antimicrobial resistance requires the development of new compounds and/or enhancers of existing compounds. Genes that protect against the lethal effects of antibiotic stress are potential targets of enhancers. To distinguish such genes from those involved in drug uptake and efflux, a new susceptibility screen is required. 相似文献16.
Background
Fast, cheap and reliable methods are needed to identify large populations, which may be at risk in relation to environmental exposure. Polymorphisms in NAT1 (N-acetyl transferase) may be suitable markers to identify individuals at risk. 相似文献17.
18.
Background
The pioneering ancestor of land plants that conquered terrestrial habitats around 500 million years ago had to face dramatic stresses including UV radiation, desiccation, and microbial attack. This drove a number of adaptations, among which the emergence of the phenylpropanoid pathway was crucial, leading to essential compounds such as flavonoids and lignin. However, the origin of this specific land plant secondary metabolism has not been clarified. 相似文献19.
Background
The formal kinetics of the H1N1 epidemic seems to take the form of an exponential curve. There is a good correlation between this theoretical model and epidemiological data on the number of H1N1-infected people. But this formal model leads to paradoxes about the dates when everyone becomes infected: in Mexico this will happen after one year, then in the rest of the world. 相似文献20.
Srinivas V Seekallu Behzad M Toosi Norman C Rawlings 《Reproductive biology and endocrinology : RB&E》2009,7(1):78