共查询到20条相似文献,搜索用时 15 毫秒
1.
Litong Nie Chao Wang Nan Li Xu Feng Namsoo Lee Dan Su Mengfan Tang Fan Yao Junjie Chen 《Molecular & cellular proteomics : MCP》2020,19(12):2015-2030
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- •Proteome analyses reveal RNF146 and TNKS1/2 substrates targeted for degradation.
- •RNF146 KO and TNKS1/2 DKO cells display significantly different proteomes.
- •RNF146 has both TNKS-dependent and -independent substrates.
2.
Eduard Hofsetz Fatih Demir Karolina Szczepanowska Alexandra Kukat Jayachandran N. Kizhakkedathu Aleksandra Trifunovic Pitter F. Huesgen 《Molecular & cellular proteomics : MCP》2020,19(8):1330-1345
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- •Mitochondrial heart N terminome shows aminopeptidase processing after MTS cleavage.
- •CLPP-deficiency alters protein processing patterns in mouse heart mitochondria.
- •Candidate substrates identified by N termini accumulation and interaction with inactive ClpXP.
- •UQCRC1, HSPA9 and OAT validated biochemically as high confidence ClpXP substrates.
3.
《Molecular & cellular proteomics : MCP》2020,19(11):1910-1920
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- •PRMT5 glutathionylation is increased in aged mice or under oxidative stress.
- •Deglutathionylation of PRMT5 is catalyzed by glutaredoxin-1.
- •PRMT5 glutathionylation decreases its methyltransferase activity.
- •PRMT5 glutathionylation results in G2/M arrest and inhibits cell proliferation.
4.
Yi-Han Lin Maryann P. Platt Haiyan Fu Yuan Gui Yanlin Wang Norberto Gonzalez-Juarbe Dong Zhou Yanbao Yu 《Molecular & cellular proteomics : MCP》2020,19(12):2030-2047
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- •Cecal Ligation Puncture (CLP) mouse model to study sepsis-induced kidney disease.
- •Quantitative global proteome and phosphoproteome profiling of mouse kidneys.
- •Highly significant candidate markers for onset and progression of AKI to CKD.
- •Mechanistic insights into sepsis-associated kidney injuries.
5.
《Molecular & cellular proteomics : MCP》2020,19(11):1896-1909
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- •Epitope-tagging of a proteasome subunit allows for facile immuno-isolation.
- •An engineered yeast strain permits capture of proteasome-associated substrates.
- •MS/MS identified all 33 resident proteasome subunits in the 20S and 19S particles.
- •Analysis of associated proteins and characterization of newly identified ERAD substrate.
6.
Felicia Grasso Stefania Mochi Federica Fratini Anna Olivieri Chiara Curr Inga Siden Kiamos Elena Deligianni Cecilia Birago Leonardo Picci Elisabetta Pizzi Tomasino Pace Marta Ponzi 《Molecular & cellular proteomics : MCP》2020,19(12):1986-1997
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- •Quantitative analysis of Plasmodium sexual stage egress secretome.
- •Activated gametocytes release gender-related proteins.
- •Gametocyte egress process involves different types of vesicles.
7.
Nataly Mancette Rijensky Netta R. Blondheim Shraga Eilon Barnea Nir Peled Eli Rosenbaum Aron Popovtzer Solomon M. Stemmer Alejandro Livoff Mark Shlapobersky Neta Moskovits Dafna Perry Eitan Rubin Itzhak Haviv Arie Admon 《Molecular & cellular proteomics : MCP》2020,19(8):1360-1374
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- •Sufficient tumor tissues are often unavailable large HLA peptidome discovery.
- •Using patient derived xenograft (PDX) tumors can overcome this limitation.
- •The large PDX HLA peptidomes expand significantly those of the original biopsies.
- •The HLA peptidomes of the PDX tumors included many tumor antigens.
8.
《Molecular & cellular proteomics : MCP》2020,19(11):1876-1895
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- •Guidelines for studying protein complexes via co-fractionation mass spectrometry.
- •A novel procedure for profiling gold standard protein complexes in CF-MS data.
- •Recommendations for efficient CF-MS fractionation collection.
- •Scoring metric recommendations for precise and sensitive CF-MS data analysis.
9.
《Molecular & cellular proteomics : MCP》2020,19(7):1120-1131
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- •Quantitative proteomics of isolated lysosomes, autophagosomes and proteasomes.
- •Pharmacological inhibition of proteasomes leads to their accumulation within lysosomes.
- •Inhibition of classical autophagy pathways cannot completely block this process.
- •Known autophagy adaptor proteins are not involved.
10.
《Molecular & cellular proteomics : MCP》2020,19(3):540-553
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- •Repeatable quantification of 200 proteins in dried blood spots.
- •Determined lower limit of quantification, repeatability, parallelism and stability.
- •Protein stability in DBS stored at ambient temperatures for up to 2 months.
- •Concentration ranges for 200 proteins in 20 healthy individuals.
11.
Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons
Charlotte A. G. H. van Gelder Renske Penning Tim S. Veth Lisa A. E. Catsburg Casper C. Hoogenraad Harold D. MacGillavry Maarten Altelaar 《Molecular & cellular proteomics : MCP》2020,19(12):1952-1968
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- •Integrated phosphoproteomics and analyses of newly synthesized proteins in neurons.
- •Resource of temporal mGluR-induced signaling pathways upon DHPG stimulation.
- •Validation of PKC, MAPK1, CAMKIIa, and CDK2 in mGluR-activation and signaling.
- •Validation of Intersectin-1 in DHPG-induced AMPAR internalization.
12.
《Molecular & cellular proteomics : MCP》2020,19(6):1005-1016
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- •Brain membrane protein extraction.
- •Protein prenylation.
- •Prenyl peptide capture and characterization by LC-MS/MS.
- •HCD and EThcD peptide fragmentation.
13.
14.
《Molecular & cellular proteomics : MCP》2020,19(6):944-959
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- •Automated statistical approach for detecting uninformative features and outliers.
- •Improved performance on relative protein quantification.
- •An option in the open-source R-based software MSstats.
15.
《Molecular & cellular proteomics : MCP》2020,19(7):1161-1178
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- •XL-MS reveals new PPIs in yeast mitochondria under glycerol and glucose condition.
- •Significant but limited results from quantitative XL-MS experiments.
- •Ndi1 participates in a CIII2CIV2 respiratory supercomplex.
- •Min8 promotes assembly of Cox12 into an intermediate complex IV.
16.
Veit Schwmmle Christina E. Hagensen Adelina Rogowska-Wrzesinska Ole N. Jensen 《Molecular & cellular proteomics : MCP》2020,19(8):1396-1408
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- •Novel statistical test combining missingness and quantitative profiles.
- •Unification of different statistical tests into a PolySTest FDR provides higher robustness and confidence.
- •PolySTest provides higher coverage of relevant biological pathways.
- •User-friendly interactive web service for statistical analysis and visualization.
17.
Anna M. Schmoker Jaye L. Weinert Jacob M. Markwood Kathryn S. Albretsen Michelle L. Lunde Marion E. Weir Alicia M. Ebert Karen L. Hinkle Bryan A. Ballif 《Molecular & cellular proteomics : MCP》2020,19(10):1586-1601
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- •FYN and ABL differentially regulate DCBLD Ser/Thr/Tyr phosphorylation.
- •DCBLD1 and DCBLD2 interactomes are modulated by FYN and ABL.
- •ABL drives a direct DCBLD2/14-3-3 interaction.
18.
Svenja Wiechmann Elena Saupp Daniela Schilling Stephanie Heinzlmeir Günter Schneider Roland M. Schmid Stephanie E. Combs Bernhard Kuster Sophie Dobiasch 《Molecular & cellular proteomics : MCP》2020,19(10):1649-1663
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- •Proteomes and phosphoproteomes of radiosensitive and radioresistant PDAC cell lines.
- •Common activation of DDR is proven by ATM activity on known and novel substrates.
- •Resistant cells bear raised NQO1 expression, actin dynamics including FAK activity.
- •Inhibitors of CHEK Rabusertib and FAK Defactinib radiosensitize PDAC cells.
19.
《Molecular & cellular proteomics : MCP》2020,19(2):278-293
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- •Longitudinal monitoring of B cell subsets shows baseline antibody gene expression.
- •A single, given CDR3 sequence can arise from more than one VJ gene combination.
- •A healthy individual's V gene usage is stable irrespective of infection and subset.
- •Surprisingly, class-switched antibodies can occur early in human B cell development.
20.
《Molecular & cellular proteomics : MCP》2020,19(2):294-307
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- •Quantitative proteomes of the cellular surface changes induced by mTORC1 signaling.
- •Hit validation in human cancer cell lines and biopsies.
- •Functional studies showing new drug targets to which cancer cells with hyperactive mTORC1 may be addicted.
- •A new paradigm for drug development, namely targeting cell surface proteins regulated by mTORC1.