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1.
《Molecular & cellular proteomics : MCP》2020,19(6):1005-1016
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- •Brain membrane protein extraction.
- •Protein prenylation.
- •Prenyl peptide capture and characterization by LC-MS/MS.
- •HCD and EThcD peptide fragmentation.
2.
《Molecular & cellular proteomics : MCP》2020,19(7):1161-1178
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- •XL-MS reveals new PPIs in yeast mitochondria under glycerol and glucose condition.
- •Significant but limited results from quantitative XL-MS experiments.
- •Ndi1 participates in a CIII2CIV2 respiratory supercomplex.
- •Min8 promotes assembly of Cox12 into an intermediate complex IV.
3.
《Molecular & cellular proteomics : MCP》2020,19(6):1047-1057
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- •DEqMS is a method for statistical analysis of quantitative MS-data.
- •Variance estimates based on the actual MS-data structure.
- •Improved statistical power and accuracy in protein differential analysis.
- •DEqMS is available as a user-friendly R package in Bioconductor.
4.
《Molecular & cellular proteomics : MCP》2020,19(5):828-838
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- •Higher AGC significantly improves quantitation quality in single-cell analysis.
- •The boosting-to-sample ratio should be carefully evaluated and optimized.
- •iBASIL allows for precise quantitation of 1,500 proteins from 104 AML single cells.
- •iBASIL recapitulates major biological differences in different AML single cells.
5.
《Molecular & cellular proteomics : MCP》2020,19(6):928-943
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- •EGFR-TKI molecular response profiling covering 10138 proteins and 13486 mRNAs.
- •EGFR-TKI combination therapy screen using a library of 528 compounds.
- •Several new candidate EGFR-TKI escape mechanisms and combination therapy targets.
- •Combined targeting of the oncogene BCL6 and EGFR results in synergy in NSCLC cells.
6.
Inga Boll Pia Jensen Veit Schwmmle Martin R. Larsen 《Molecular & cellular proteomics : MCP》2020,19(9):1418-1435
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- •Comprehensive sialiomics of isolated rat synaptosomes.
- •Site-specific modulation of sialic acids on surface glycoproteins after brief depolarization.
- •Sialylation as dynamic modification important for synaptic depolarization-dependent processes.
7.
《Molecular & cellular proteomics : MCP》2020,19(1):128-141
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- •Laser microdissection of highly vulnerable hippocampal region.
- •Proteomic analysis of postmortem human brain tissue of AD and control cases.
- •Decreased levels of presynaptic proteins, but not postsynaptic proteins, in AD.
- •Immunohistochemistry verifies decreased levels of selected presynaptic proteins.
8.
《Molecular & cellular proteomics : MCP》2020,19(3):478-489
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- •Comprehensive molecular profiling of cutaneous and cerebellar metastasis variants.
- •Identification of differentially regulated metastasis-associated molecules.
- •Evidence for individually distinct patterns of metastasis-associated molecules.
- •Highlighting the evident need for establishing meta-analyses strategies.
9.
Fengchao Yu Sarah E. Haynes Guo Ci Teo Dmitry M. Avtonomov Daniel A. Polasky Alexey I. Nesvizhskii 《Molecular & cellular proteomics : MCP》2020,19(9):1575-1585
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- •MSFragger now supports raw timsTOF PASEF data.
- •IonQuant performs fast and accurate feature detection and quantification.
- •MSFragger and IonQuant provide excellent performance for timsTOF PASEF data.
- •Flexibility allows for complex analyses, such as semi-enzymatic and open search.
10.
《Molecular & cellular proteomics : MCP》2020,19(11):1777-1789
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- •Quantitative mass spectrometric method to monitor PTM stability.
- •Pulse labeling reveals dehydroxylation of several asparagine hydroxylation sites.
- •Reversal of TNKS2, TRPV3 and HIF1a asparagine hydroxylation sites.
- •Protein dehydroxylation is an additional level of control for cellular signaling networks.
11.
《Molecular & cellular proteomics : MCP》2020,19(11):1896-1909
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- •Epitope-tagging of a proteasome subunit allows for facile immuno-isolation.
- •An engineered yeast strain permits capture of proteasome-associated substrates.
- •MS/MS identified all 33 resident proteasome subunits in the 20S and 19S particles.
- •Analysis of associated proteins and characterization of newly identified ERAD substrate.
12.
《Molecular & cellular proteomics : MCP》2020,19(4):730-743
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- •Detection of low-abundance phosphotyrosine-containing peptides is challenging.
- •Multiplexed TMT allows inclusion of modification(pTyr)-saturated boost channels.
- •Boost channels facilitate selection of pTyr precursor ions for fragmentation.
- •Quantitation depth is increased while maintaining accuracy and precision.
13.
Proteomics of Galápagos Marine Iguanas Links Function of Femoral Gland Proteins to the Immune System
Frederik Tellkamp Franziska Lang Alejandro Ibez Lena Abraham Galo Quezada Stefan Günther Mario Looso Fabian Jannik Tann Daniela Müller Franz Cemic Jürgen Hemberger Sebastian Steinfartz Marcus Krüger 《Molecular & cellular proteomics : MCP》2020,19(9):1523-1532
14.
《Molecular & cellular proteomics : MCP》2020,19(7):1209-1219
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- •In depth performance assessment of leading tools for differential protein abundance.
- •Novel fast modular framework MSqRobSum for robust protein summarization and inference.
- •MsqRobSum outperforms leading protein summarization-based tools.
- •MSqRobSum is on par with top-performing peptide based tool MSqRob.
15.
《Molecular & cellular proteomics : MCP》2020,19(2):390-404
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- •Curation of 2066 phosphorylated HLA class I peptides from immunopeptidomics data.
- •Determination of 22 HLA class I binding motifs for phosphorylated peptides.
- •Observation of a higher frequency of phosphorylated ligands binding HLA-C molecules.
- •Development of a predictor of phosphorylated peptide interactions with HLA class I.
16.
《Molecular & cellular proteomics : MCP》2020,19(4):574-588
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- •SILAC-based protein quantification of OA hBMSCs undergoing chondrogenesis.
- •Spatially-resolved metabolomics by MSI of hBMSCs in chondrogenic differentiation.
- •Differential metabolic pathways involved in OA compared to control hBMSCs.
- •UDP-glucuronic acid/UDP-GlcNAc synthesis is decreased in chondrogenic OA hBMSCs.
17.
Prashali Bansal Johannes Madlung Kristina Schaaf Boris Macek Fulvia Bono 《Molecular & cellular proteomics : MCP》2020,19(9):1485-1502
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- •Label-free and dimethyl labeling MS analysis of 6 RBPs from Drosophila ovaries.
- •Functionally related RBPs show overlapping proteomes.
- •Selective co-purification of splicing factors and translational regulators.
- •Validation of 26 novel interactions by co-immunoprecipitation.
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19.
Fei Fang Qun Zhao Huiying Chu Mingwei Liu Baofeng Zhao Zhen Liang Lihua Zhang Guohui Li Liming Wang Jun Qin Yukui Zhang 《Molecular & cellular proteomics : MCP》2020,19(10):1724-1737
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- •Mechanistic insights into ionic liquids and proteins at molecular level.
- •Extractants prescreen for proteome analysis with MD simulation system.
- •A loss-less sample preparation method developed for in-depth proteome profiling.
- •Over 3,300 proteins were confidently identified from 1,000 HeLa cells in a 1 h run.
- •Label-free quantitative proteome analysis of human liver cancer tissues.
20.
Jana Zecha Chien-Yun Lee Florian P. Bayer Chen Meng Vincent Grass Johannes Zerweck Karsten Schnatbaum Thomas Michler Andreas Pichlmair Christina Ludwig Bernhard Kuster 《Molecular & cellular proteomics : MCP》2020,19(9):1503-1522
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- •In-depth proteomes of 4 SARS-CoV-2 cell line models (Vero E6, Calu-3, Caco-2, A549).
- •Proteomic evidence for thousands of Chlorocebus sabaeus proteins.
- •Proteomic response of Vero E6 cells to SARS-CoV-2 infection.
- •Synthetic peptides, spectral libraries, and targeted assays for SARS-CoV-2 proteins.