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1.
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Highlights
  • •SILAC-based protein quantification of OA hBMSCs undergoing chondrogenesis.
  • •Spatially-resolved metabolomics by MSI of hBMSCs in chondrogenic differentiation.
  • •Differential metabolic pathways involved in OA compared to control hBMSCs.
  • •UDP-glucuronic acid/UDP-GlcNAc synthesis is decreased in chondrogenic OA hBMSCs.
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2.
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Highlights
  • •Organelle profiling maps capture localizations of 1000s of proteins in one experiment.
  • •Comparing maps +/− perturbation reveals disease mechanisms & cellular responses.
  • •A conceptual guide to planning and interpreting organellar profiling experiments.
  • •A cross-study consensus set of human organellar marker proteins.
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3.
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Highlights
  • •Human spermatozoa possess cells of poor morphology that lack nuclear integrity.
  • •These cells can be isolated by density separation.
  • •Mass spectrometry reveals their nuclei contain excess protein.
  • •TOP2A is a promising marker of this poor nuclear development.
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4.
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Highlights
  • •PRMT5 glutathionylation is increased in aged mice or under oxidative stress.
  • •Deglutathionylation of PRMT5 is catalyzed by glutaredoxin-1.
  • •PRMT5 glutathionylation decreases its methyltransferase activity.
  • •PRMT5 glutathionylation results in G2/M arrest and inhibits cell proliferation.
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5.
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Highlights
  • •Acute inhibition of growth-regulatory AGC-kinases Sch9, PKA and Ypk1.
  • •Phospho-proteomic profiling of 6373 phsopho-sites.
  • •Ypk1 regulates phospho-sites in RRxS/T-context and functionally overlaps with PKA.
  • •Ypk1 and PKA activate trehalase activity of Nth1.
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6.
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Highlights
  • •NCMR is crucial for substrate recognition and activity regulation.
  • •MASTL conserves a cryptic C-Lobe in the non-conserved middle region.
  • •MASTL450 containing the cryptic C-lobe is observed in cancer cell lines.
  • •Key phosphorylation sites for MASTL provide an activation model.
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7.
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Highlights
  • •Two molecular groups in anal squamous carcinoma according proteomic profile.
  • •Differences in possible targeted processes such as metabolism or immune response.
  • •Different percentage of tumor lymphocyte infiltration.
  • •Difference in the frequency of ATM variants, related to PPAR inhibitors.
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8.
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Highlights
  • •Brain membrane protein extraction.
  • •Protein prenylation.
  • •Prenyl peptide capture and characterization by LC-MS/MS.
  • •HCD and EThcD peptide fragmentation.
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9.
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Highlights
  • •pY phosphoproteomes and dedicated ranking analyses for 16 AML cell lines.
  • •RTK drivers, 6 mutant cell lines confirmed, identification for 4 more cell lines.
  • •MAPK1/3 phosphorylation for cell lines without TK driver, indicating RAS mutation.
  • •Drug target space phosphorylation correlates with drug IC50s in specific cell lines.
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10.
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Highlights
  • •Longitudinal monitoring of B cell subsets shows baseline antibody gene expression.
  • •A single, given CDR3 sequence can arise from more than one VJ gene combination.
  • •A healthy individual's V gene usage is stable irrespective of infection and subset.
  • •Surprisingly, class-switched antibodies can occur early in human B cell development.
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11.
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Highlights
  • •Quantitative proteomes of the cellular surface changes induced by mTORC1 signaling.
  • •Hit validation in human cancer cell lines and biopsies.
  • •Functional studies showing new drug targets to which cancer cells with hyperactive mTORC1 may be addicted.
  • •A new paradigm for drug development, namely targeting cell surface proteins regulated by mTORC1.
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12.
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Highlights
  • •Sufficient tumor tissues are often unavailable large HLA peptidome discovery.
  • •Using patient derived xenograft (PDX) tumors can overcome this limitation.
  • •The large PDX HLA peptidomes expand significantly those of the original biopsies.
  • •The HLA peptidomes of the PDX tumors included many tumor antigens.
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13.
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Highlights
  • •Higher AGC significantly improves quantitation quality in single-cell analysis.
  • •The boosting-to-sample ratio should be carefully evaluated and optimized.
  • •iBASIL allows for precise quantitation of 1,500 proteins from 104 AML single cells.
  • •iBASIL recapitulates major biological differences in different AML single cells.
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14.
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Highlights
  • •Urinary proteomes of patients with recurrent UTI, renal scarring, and VUR.
  • •80 proteins differentially expressed, compared to healthy controls.
  • •62 proteins may be indicative of susceptibility for UTI.
  • •Altered acute phase response, extracellular matrix and carbohydrate metabolism.
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15.
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Highlights
  • •N-glycan patterns are distinct in pediatric and adult urine.
  • •Sex differences of N-glycans are much larger in adults.
  • •Pediatric urine has almost no sex differences in N-glycan levels.
  • •In adults, the majority of N-glycans were more abundant in males.
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16.
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Highlights
  • •Cecal Ligation Puncture (CLP) mouse model to study sepsis-induced kidney disease.
  • •Quantitative global proteome and phosphoproteome profiling of mouse kidneys.
  • •Highly significant candidate markers for onset and progression of AKI to CKD.
  • •Mechanistic insights into sepsis-associated kidney injuries.
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17.
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Highlights
  • P. aeruginosa grown with exosiderophores and analyzed by proteomic and RT-qPCR.
  • •Catechol-type exosiderophores strongly induce the expression of their transporters.
  • •Repression of the endogenous iron uptake pathways.
  • •Complex phenotypic plasticity in the expression of the various iron-uptake pathways.
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18.
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Highlights
  • •cGAS acetylations and phosphorylations under basal and immune-stimulated states.
  • •K384 and K414 acetylations and S305 phosphorylation inhibit cGAS-mediated apoptosis.
  • •Acetylation at K198 stimulates cGAS-dependent interferon signaling.
  • •K198 acetylation is decreased upon herpesvirus infection.
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19.
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Highlights
  • •Co-elution stands out as a global interactome mapping method.
  • •Benefits include all-to-all protein analysis and measurement of interactome perturbations.
  • •Different separation, quantification and bioinformatic strategies are available.
  • •Design considerations depend largely on system under study.
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20.
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Highlights
  • •BioID reveals the proximity partners of RSK family members.
  • •All RSK isoforms associate with and phosphorylate p120ctn on Ser320.
  • •RSK negatively regulates adherens junctions and reduces cell-cell adhesion.
  • •p120ctn phosphorylation plays a role in the reorganization of proximity partners.
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