共查询到20条相似文献,搜索用时 15 毫秒
1.
Felicia Grasso Stefania Mochi Federica Fratini Anna Olivieri Chiara Curr Inga Siden Kiamos Elena Deligianni Cecilia Birago Leonardo Picci Elisabetta Pizzi Tomasino Pace Marta Ponzi 《Molecular & cellular proteomics : MCP》2020,19(12):1986-1997
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- •Quantitative analysis of Plasmodium sexual stage egress secretome.
- •Activated gametocytes release gender-related proteins.
- •Gametocyte egress process involves different types of vesicles.
2.
《Molecular & cellular proteomics : MCP》2020,19(11):1749-1759
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- •In-depth profiling of the serum proteome in early-stage COVID-19 patients.
- •A landscape of inflammation and immune signaling related to the SARS-CoV-2 infection.
- •CCL2 and CXCL10 medicated cytokine signaling pathways may correlate with neutrophil and lymphocyte respectively.
3.
《Molecular & cellular proteomics : MCP》2020,19(11):1910-1920
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- •PRMT5 glutathionylation is increased in aged mice or under oxidative stress.
- •Deglutathionylation of PRMT5 is catalyzed by glutaredoxin-1.
- •PRMT5 glutathionylation decreases its methyltransferase activity.
- •PRMT5 glutathionylation results in G2/M arrest and inhibits cell proliferation.
4.
《Molecular & cellular proteomics : MCP》2020,19(3):456-466
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- •Urinary proteomes of patients with recurrent UTI, renal scarring, and VUR.
- •80 proteins differentially expressed, compared to healthy controls.
- •62 proteins may be indicative of susceptibility for UTI.
- •Altered acute phase response, extracellular matrix and carbohydrate metabolism.
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Nataly Mancette Rijensky Netta R. Blondheim Shraga Eilon Barnea Nir Peled Eli Rosenbaum Aron Popovtzer Solomon M. Stemmer Alejandro Livoff Mark Shlapobersky Neta Moskovits Dafna Perry Eitan Rubin Itzhak Haviv Arie Admon 《Molecular & cellular proteomics : MCP》2020,19(8):1360-1374
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- •Sufficient tumor tissues are often unavailable large HLA peptidome discovery.
- •Using patient derived xenograft (PDX) tumors can overcome this limitation.
- •The large PDX HLA peptidomes expand significantly those of the original biopsies.
- •The HLA peptidomes of the PDX tumors included many tumor antigens.
6.
《Molecular & cellular proteomics : MCP》2020,19(2):233-244
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- •Mapping kinase-substrate relationships is vital in discovering new tuberculosis drug targets.
- •LC-MS/MS-based phosphoproteomics expand mycobacterial STPK substrate catalogues.
- •We review and integrate MS-generated datasets on novel candidate substrates.
- •Validation studies are necessary to confirm true physiological substrates of STPKs.
7.
《Molecular & cellular proteomics : MCP》2020,19(7):1120-1131
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- •Quantitative proteomics of isolated lysosomes, autophagosomes and proteasomes.
- •Pharmacological inhibition of proteasomes leads to their accumulation within lysosomes.
- •Inhibition of classical autophagy pathways cannot completely block this process.
- •Known autophagy adaptor proteins are not involved.
8.
《Molecular & cellular proteomics : MCP》2020,19(3):540-553
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- •Repeatable quantification of 200 proteins in dried blood spots.
- •Determined lower limit of quantification, repeatability, parallelism and stability.
- •Protein stability in DBS stored at ambient temperatures for up to 2 months.
- •Concentration ranges for 200 proteins in 20 healthy individuals.
9.
《Molecular & cellular proteomics : MCP》2020,19(11):1876-1895
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- •Guidelines for studying protein complexes via co-fractionation mass spectrometry.
- •A novel procedure for profiling gold standard protein complexes in CF-MS data.
- •Recommendations for efficient CF-MS fractionation collection.
- •Scoring metric recommendations for precise and sensitive CF-MS data analysis.
10.
Eduard Hofsetz Fatih Demir Karolina Szczepanowska Alexandra Kukat Jayachandran N. Kizhakkedathu Aleksandra Trifunovic Pitter F. Huesgen 《Molecular & cellular proteomics : MCP》2020,19(8):1330-1345
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- •Mitochondrial heart N terminome shows aminopeptidase processing after MTS cleavage.
- •CLPP-deficiency alters protein processing patterns in mouse heart mitochondria.
- •Candidate substrates identified by N termini accumulation and interaction with inactive ClpXP.
- •UQCRC1, HSPA9 and OAT validated biochemically as high confidence ClpXP substrates.
11.
《Molecular & cellular proteomics : MCP》2020,19(1):31-49
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- •Immunopeptidomics bears the potential to link diseases to antigen representation.
- •We suggest to achieve this by analyzing the immunopeptidomes of cohorts of patients.
- •Current mass spectrometry-based techniques to analyze immunopeptidomes are described.
- •We term the proposed approach “Immunopeptidome-wide association studies” (IWAS).
12.
《Molecular & cellular proteomics : MCP》2020,19(1):128-141
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- •Laser microdissection of highly vulnerable hippocampal region.
- •Proteomic analysis of postmortem human brain tissue of AD and control cases.
- •Decreased levels of presynaptic proteins, but not postsynaptic proteins, in AD.
- •Immunohistochemistry verifies decreased levels of selected presynaptic proteins.
13.
Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons
Charlotte A. G. H. van Gelder Renske Penning Tim S. Veth Lisa A. E. Catsburg Casper C. Hoogenraad Harold D. MacGillavry Maarten Altelaar 《Molecular & cellular proteomics : MCP》2020,19(12):1952-1968
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- •Integrated phosphoproteomics and analyses of newly synthesized proteins in neurons.
- •Resource of temporal mGluR-induced signaling pathways upon DHPG stimulation.
- •Validation of PKC, MAPK1, CAMKIIa, and CDK2 in mGluR-activation and signaling.
- •Validation of Intersectin-1 in DHPG-induced AMPAR internalization.
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15.
《Molecular & cellular proteomics : MCP》2020,19(6):1005-1016
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- •Brain membrane protein extraction.
- •Protein prenylation.
- •Prenyl peptide capture and characterization by LC-MS/MS.
- •HCD and EThcD peptide fragmentation.
16.
《Molecular & cellular proteomics : MCP》2020,19(6):944-959
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- •Automated statistical approach for detecting uninformative features and outliers.
- •Improved performance on relative protein quantification.
- •An option in the open-source R-based software MSstats.
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18.
Litong Nie Chao Wang Nan Li Xu Feng Namsoo Lee Dan Su Mengfan Tang Fan Yao Junjie Chen 《Molecular & cellular proteomics : MCP》2020,19(12):2015-2030
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- •Proteome analyses reveal RNF146 and TNKS1/2 substrates targeted for degradation.
- •RNF146 KO and TNKS1/2 DKO cells display significantly different proteomes.
- •RNF146 has both TNKS-dependent and -independent substrates.
19.
zge Karayel Francesca Tonelli Sebastian Virreira Winter Phillip E. Geyer Ying Fan Esther M. Sammler Dario R. Alessi Martin Steger Matthias Mann 《Molecular & cellular proteomics : MCP》2020,19(9):1546-1560
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- •MS-based clinical assay that accurately determines phospho Rab10 occupancy.
- •Stable isotope labeled phosphopeptide injected as a standard with endogenous tryptic phospho Rab peptide for accurate ratio determination.
- •Determination of pRab levels in neutrophils of Parkinson disease patients.
- •Relevance of pRab levels as marker of PD.
20.
《Molecular & cellular proteomics : MCP》2020,19(5):839-851
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- •A detailed investigation of the protein extraction step from FFPE tissue is shown.
- •Acidification during peptide wash increased peptide recovery of the SP3 method.
- •LCM of substantia nigra enriched neuron-specific proteins including TH.
- •>5,600 proteins were quantified using 3000 cells per sample from substantia nigra.